{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,3]],"date-time":"2025-12-03T17:39:27Z","timestamp":1764783567126},"reference-count":27,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2013,12,24]],"date-time":"2013-12-24T00:00:00Z","timestamp":1387843200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Transplantation"],"published-print":{"date-parts":[[2014,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Mycophenolic acid Observational REnal transplant (<jats:styled-content style=\"fixed-case\">MORE<\/jats:styled-content>) was a prospective, observational study of <jats:italic>de novo<\/jats:italic> kidney transplant patients receiving mycophenolic acid (<jats:styled-content style=\"fixed-case\">MPA<\/jats:styled-content>). Four\u2010yr data on 904 patients receiving tacrolimus and enteric\u2010coated mycophenolate sodium (<jats:styled-content style=\"fixed-case\">EC<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">MPS<\/jats:styled-content>) or mycophenolate mofetil (<jats:styled-content style=\"fixed-case\">MMF<\/jats:styled-content>) were analyzed to evaluate immunosuppression and graft outcomes in African American (<jats:styled-content style=\"fixed-case\">AA<\/jats:styled-content>, n\u00a0=\u00a0218) vs. non\u2010<jats:styled-content style=\"fixed-case\">AA<\/jats:styled-content> (n\u00a0=\u00a0686) patients. Mean tacrolimus dose was higher in <jats:styled-content style=\"fixed-case\">AA<\/jats:styled-content> vs. non\u2010<jats:styled-content style=\"fixed-case\">AA<\/jats:styled-content> patients but mean tacrolimus trough concentration was similar. Use of the recommended <jats:styled-content style=\"fixed-case\">MPA<\/jats:styled-content> dose in <jats:styled-content style=\"fixed-case\">AA<\/jats:styled-content> patients decreased from 78.9% at baseline to 33.1% at year 3. More <jats:styled-content style=\"fixed-case\">AA<\/jats:styled-content> patients received the recommended <jats:styled-content style=\"fixed-case\">MPA<\/jats:styled-content> dose with <jats:styled-content style=\"fixed-case\">EC<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">MPS<\/jats:styled-content> than <jats:styled-content style=\"fixed-case\">MMF<\/jats:styled-content> at month 6 (56.2% vs. 35.7%, p\u00a0=\u00a00.016) and month 36 (46.6% vs. 16.7%, p\u00a0=\u00a00.029), with no safety penalty. Significantly, more <jats:styled-content style=\"fixed-case\">AA<\/jats:styled-content> patients received corticosteroids than non\u2010<jats:styled-content style=\"fixed-case\">AA<\/jats:styled-content> patients. Biopsy\u2010proven acute rejection was higher in <jats:styled-content style=\"fixed-case\">AA<\/jats:styled-content> vs. non\u2010<jats:styled-content style=\"fixed-case\">AA<\/jats:styled-content> patients (18.9% vs. 10.7%, p\u00a0=\u00a00.003), as was graft loss (10.9% vs. 4.4%, p\u00a0=\u00a00.003); differences were confirmed by Cox regression analysis. Patient survival was similar. Estimated <jats:styled-content style=\"fixed-case\">GFR<\/jats:styled-content> was comparable in <jats:styled-content style=\"fixed-case\">AA<\/jats:styled-content> vs. non\u2010<jats:styled-content style=\"fixed-case\">AA<\/jats:styled-content> patients. Kidney allograft survival remains lower for <jats:styled-content style=\"fixed-case\">AA<\/jats:styled-content> vs. non\u2010<jats:styled-content style=\"fixed-case\">AA<\/jats:styled-content> recipients even under the current standard of care.<\/jats:p>","DOI":"10.1111\/ctr.12294","type":"journal-article","created":{"date-parts":[[2013,12,24]],"date-time":"2013-12-24T07:08:50Z","timestamp":1387868930000},"page":"184-191","source":"Crossref","is-referenced-by-count":21,"title":["Long\u2010term outcomes in African American kidney transplant recipients under contemporary immunosuppression: a four\u2010yr analysis of the Mycophenolic acid Observational REnal transplant (MORE) study"],"prefix":"10.1111","volume":"28","author":[{"given":"Mohanram","family":"Narayanan","sequence":"first","affiliation":[{"name":"Scott and White Healthcare Temple TX 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