{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,20]],"date-time":"2026-05-20T00:26:01Z","timestamp":1779236761455,"version":"3.51.4"},"reference-count":25,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2013,12,26]],"date-time":"2013-12-26T00:00:00Z","timestamp":1388016000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Transplantation"],"published-print":{"date-parts":[[2014,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Atherosclerotic lesions within the graft are considered to be a major cause of interstitial fibrosis\/tubular atrophy (IF\/TA). We evaluated the factors that influence the development of IF\/TA and three\u2010 and five\u2010yr graft survival including nitric oxide synthase (<jats:styled-content style=\"fixed-case\">eNOS<\/jats:styled-content>) and angiotensin II type 1 and type 2 receptor gene polymorphism.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Seventy\u2010one male and 35 female patients (age: 34.9\u00a0\u00b1\u00a011.2\u00a0yr) who underwent living\u2010related renal transplantation were included. Angiotensin type 1 and type 2 receptor gene polymorphisms and <jats:styled-content style=\"fixed-case\">eNOS<\/jats:styled-content> intron 4 gene polymorphism were analyzed. The pre\u2010 and post\u2010transplant laboratory data, patient characteristics, acute rejection episodes, and presence of IF\/TA were evaluated.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Patients with the bb allele of <jats:styled-content style=\"fixed-case\">eNOS<\/jats:styled-content> gene had a lower prevalence of post\u2010transplant third year (12.6% and 38.5%, p\u00a0=\u00a00.005) and fifth year IF\/TA (46.6% and 82.3%, p\u00a0=\u00a00.02) and a lower incidence of five\u2010yr graft failure (35.4% and 55.6%, p\u00a0&lt;\u00a00.005). The <jats:styled-content style=\"fixed-case\">eNOS<\/jats:styled-content> gene polymorphism was independent and was the most prominent factor associated with third and fifth year IF\/TA (p\u00a0=\u00a00.01, RR: 29.72, and p\u00a0=\u00a00.03, RR: 4.1, respectively). No significant relationship existed when angiotensin II gene polymorphisms were considered.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>We concluded that recipient <jats:styled-content style=\"fixed-case\">eNOS<\/jats:styled-content> gene polymorphism can predict IF\/TA, and the presence of the bb allele is associated with better graft outcome.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ctr.12302","type":"journal-article","created":{"date-parts":[[2013,12,26]],"date-time":"2013-12-26T11:46:42Z","timestamp":1388058402000},"page":"223-228","source":"Crossref","is-referenced-by-count":3,"title":["Endothelial nitric oxide synthase polymorphism influences renal allograft outcome"],"prefix":"10.1111","volume":"28","author":[{"given":"Murathan","family":"Uyar","sequence":"first","affiliation":[{"name":"Department of Nephrology Baskent University Faculty of Medicine Ankara Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Siren","family":"Sezer","sequence":"additional","affiliation":[{"name":"Department of Nephrology Baskent University Faculty of Medicine Ankara Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fatma Nurhan","family":"Ozdemir","sequence":"additional","affiliation":[{"name":"Department of Nephrology Baskent University Faculty of Medicine Ankara Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eyup","family":"Kulah","sequence":"additional","affiliation":[{"name":"Department of Nephrology Baskent University Faculty of Medicine Ankara Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zubeyde","family":"Arat","sequence":"additional","affiliation":[{"name":"Department of Nephrology Baskent University Faculty of Medicine Ankara Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fatma Belgin","family":"Atac","sequence":"additional","affiliation":[{"name":"Department of Molecular Biology Baskent University Faculty of Medicine Ankara Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mehmet","family":"Haberal","sequence":"additional","affiliation":[{"name":"Department of General Surgery Baskent University Faculty of Medicine Ankara 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