{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T03:04:25Z","timestamp":1782961465966,"version":"3.54.5"},"reference-count":33,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2014,3,19]],"date-time":"2014-03-19T00:00:00Z","timestamp":1395187200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Transplantation"],"published-print":{"date-parts":[[2014,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The aim of the study was to investigate whether serum levels of intact parathyroid hormone (<jats:styled-content style=\"fixed-case\">iPTH<\/jats:styled-content>) are associated with an increased risk of cardiovascular events, graft loss, or mortality in kidney transplant patients with optimal transplant function.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>From the Norwegian Renal Registry, we identified 522 patients who received a first kidney transplant from 2001 to 2008 with optimal transplant function defined as an estimated glomerular filtration rate (<jats:styled-content style=\"fixed-case\">eGFR<\/jats:styled-content>)\u00a0\u2265\u00a060\u00a0mL\/min\/1.73\u00a0m<jats:sup>2<\/jats:sup>, more than one\u00a0yr after transplantation. Cox's proportional hazard models were used to assess the association between <jats:styled-content style=\"fixed-case\">iPTH<\/jats:styled-content> measured 10\u00a0wk after transplantation and the composite endpoint. The estimates were adjusted for age, gender, serum calcium, serum phosphate, diabetes mellitus, cardiovascular disease, and time on dialysis prior to transplantation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Median follow\u2010up time was 3.9\u00a0yr (interquartile range, IQR: 2.0\u20136.0\u00a0yr). Patients in the third <jats:styled-content style=\"fixed-case\">iPTH<\/jats:styled-content> quartile (9.3\u201314.4\u00a0pM) had the lowest risk for reaching the composite endpoint. Patients in the fourth <jats:styled-content style=\"fixed-case\">iPTH<\/jats:styled-content> quartile (&gt;14.4\u00a0pM) had an increased risk compared to those in the third quartile (HR: 2.60, 95% CI: 1.10\u20136.16, p\u00a0=\u00a00.03).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>In patients with optimal transplant function, <jats:styled-content style=\"fixed-case\">iPTH<\/jats:styled-content> levels are associated with a clinical outcome consisting of cardiovascular events, graft loss, and all\u2010cause mortality.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ctr.12341","type":"journal-article","created":{"date-parts":[[2014,2,24]],"date-time":"2014-02-24T18:26:45Z","timestamp":1393266405000},"page":"479-486","source":"Crossref","is-referenced-by-count":34,"title":["Parathyroid hormone and clinical outcome in kidney transplant patients with optimal transplant function"],"prefix":"10.1111","volume":"28","author":[{"given":"Inger H.","family":"Bleskestad","sequence":"first","affiliation":[{"name":"Department of Medicine Stavanger University Hospital Stavanger Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Harald","family":"Bergrem","sequence":"additional","affiliation":[{"name":"Department of Medicine Stavanger University Hospital Stavanger Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Torbj\u00f8rn","family":"Leivestad","sequence":"additional","affiliation":[{"name":"Department of Organ Transplantation Norwegian Renal Registry Oslo University Hospital, Rikshospitalet Oslo Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anders","family":"Hartmann","sequence":"additional","affiliation":[{"name":"Department of Organ Transplantation Oslo University Hospital, Rikshospitalet Oslo Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lasse G.","family":"G\u00f8ransson","sequence":"additional","affiliation":[{"name":"Department of Medicine Stavanger University Hospital Stavanger Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2014,3,19]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.HYP.0000102971.85504.7c"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199912023412303"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.V1191735"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.ki.5002009"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/ki.2008.64"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gfq219"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/13.9.2294"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2362.2006.01665.x"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/ki.1994.342"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1159\/000130690"},{"key":"e_1_2_9_12_1","first-page":"S1","article-title":"KDIGO clinical practice guideline for the diagnosis, evaluation, prevention, and treatment of Chronic Kidney Disease\u2010Mineral and Bone Disorder (CKD\u2010MBD)","volume":"113","author":"Kidney Disease: Improving Global Outcomes CKDMBDWG","year":"2009","journal-title":"Kidney Int Suppl"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.ndt.a027843"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gfh128"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1080\/00365590701421389"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-0012.2011.01515.x"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-130-6-199903160-00002"},{"issue":"4","key":"e_1_2_9_18_1","first-page":"60","article-title":"European best practice guidelines for renal transplantation. 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