{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T01:45:14Z","timestamp":1760147114363},"reference-count":22,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2014,4,2]],"date-time":"2014-04-02T00:00:00Z","timestamp":1396396800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Transplantation"],"published-print":{"date-parts":[[2014,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Human herpesvirus\u20106 (<jats:styled-content style=\"fixed-case\">HHV<\/jats:styled-content>\u20106) encephalopathy is a serious complication of allogeneic hematopoietic stem cell transplantation (allo\u2010<jats:styled-content style=\"fixed-case\">HSCT<\/jats:styled-content>). Although reactivation of <jats:styled-content style=\"fixed-case\">HHV<\/jats:styled-content>\u20106 is often observed after allo\u2010<jats:styled-content style=\"fixed-case\">HSCT<\/jats:styled-content>, encephalopathy only affects a few patients with <jats:styled-content style=\"fixed-case\">HHV<\/jats:styled-content>\u20106 reactivation. Human leukocyte antigen (<jats:styled-content style=\"fixed-case\">HLA<\/jats:styled-content>) class I is expressed by most somatic cells, and a relationship between some class I alleles and neurological diseases has been reported. The <jats:styled-content style=\"fixed-case\">HHV<\/jats:styled-content>\u20106 load at two, three, and four weeks after allo\u2010<jats:styled-content style=\"fixed-case\">HSCT<\/jats:styled-content> was examined. <jats:styled-content style=\"fixed-case\">HHV<\/jats:styled-content>\u20106 encephalopathy was diagnosed from symptoms, results of cerebrospinal fluid examination, and magnetic resonance imaging findings. The relation between <jats:styled-content style=\"fixed-case\">HHV<\/jats:styled-content>\u20106 reactivation or encephalopathy and the <jats:styled-content style=\"fixed-case\">HLA<\/jats:styled-content> class I status of the recipients was investigated. In 130 patients, 147 allo\u2010<jats:styled-content style=\"fixed-case\">HSCT<\/jats:styled-content> transplantation procedures were carried out. <jats:styled-content style=\"fixed-case\">HHV<\/jats:styled-content>\u20106 reactivation and encephalopathy occurred in 56 and nine procedures, respectively. <jats:styled-content style=\"fixed-case\">HLA<\/jats:styled-content> mismatch (p\u00a0=\u00a00.008) and unrelated donor (p\u00a0=\u00a00.001) were associated with <jats:styled-content style=\"fixed-case\">HHV<\/jats:styled-content>\u20106 reactivation, but not with <jats:styled-content style=\"fixed-case\">HHV<\/jats:styled-content>\u20106 encephalopathy. <jats:styled-content style=\"fixed-case\">HHV<\/jats:styled-content>\u20106 encephalopathy was more frequent in patients with <jats:styled-content style=\"fixed-case\">HLA<\/jats:styled-content>\u2010B*40:06 (p\u00a0=\u00a00.027). In addition, <jats:styled-content style=\"fixed-case\">HLA<\/jats:styled-content>\u2010A*26:01 and <jats:styled-content style=\"fixed-case\">HLA<\/jats:styled-content>\u2010B*40:06 were found to be associated with each other (p\u00a0=\u00a00.089), while <jats:styled-content style=\"fixed-case\">HLA<\/jats:styled-content>\u2010B*40:06 and <jats:styled-content style=\"fixed-case\">HLA<\/jats:styled-content>\u2010C*08:01 showed a significant association (p\u00a0&lt;\u00a00.001). The <jats:styled-content style=\"fixed-case\">HLA<\/jats:styled-content> class I alleles of recipients may be associated with the occurrence of <jats:styled-content style=\"fixed-case\">HHV<\/jats:styled-content>\u20106 encephalopathy after allo\u2010<jats:styled-content style=\"fixed-case\">HSCT<\/jats:styled-content>.<\/jats:p>","DOI":"10.1111\/ctr.12342","type":"journal-article","created":{"date-parts":[[2014,3,3]],"date-time":"2014-03-03T09:31:20Z","timestamp":1393839080000},"page":"540-545","source":"Crossref","is-referenced-by-count":8,"title":["Human herpesvirus\u20106 encephalopathy after hematopoietic stem cell transplantation and class I human leukocyte antigen"],"prefix":"10.1111","volume":"28","author":[{"given":"Wataru","family":"Yamamoto","sequence":"first","affiliation":[{"name":"Department of Hematology Kanagawa Cancer Center Yokohama Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eriko","family":"Ogusa","sequence":"additional","affiliation":[{"name":"Department of Hematology Kanagawa Cancer Center Yokohama Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kenji","family":"Matsumoto","sequence":"additional","affiliation":[{"name":"Department of Hematology Kanagawa Cancer Center Yokohama Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Atsuo","family":"Maruta","sequence":"additional","affiliation":[{"name":"Department of Hematology Kanagawa Cancer Center Yokohama Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoshiaki","family":"Ishigatsubo","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine and Clinical Immunology Yokohama City University Graduate School of Medicine Yokohama 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