{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,14]],"date-time":"2026-07-14T02:42:54Z","timestamp":1783996974304,"version":"3.55.0"},"reference-count":39,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2014,4,11]],"date-time":"2014-04-11T00:00:00Z","timestamp":1397174400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Transplantation"],"published-print":{"date-parts":[[2014,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Individuals with moderate\u2010to\u2010severe reduced renal function have greater risk of gastrointestinal bleeding than those with normal renal function. We conducted a retrospective matched cohort study to assess whether living kidney donors share a similar risk. We reviewed pre\u2010donation charts for living kidney donations from 1992 to 2009 in Ontario, Canada, and linked this information to healthcare databases. We selected healthy non\u2010donors from the general population and matched ten non\u2010donors to every donor. Of the 2009 donors and 20\u00a0090 matched non\u2010donors, none had evidence of gastrointestinal bleeding prior to cohort entry. The cohort was followed for a median of 8.4\u00a0yr (maximum 19.7\u00a0yr; loss to follow\u2010up &lt;7%). There was no significant difference in the rate of hospitalization with gastrointestinal bleeding in donors compared to non\u2010donors (18.5 vs. 14.9 events per 10\u00a0000 person\u2010years; rate ratio 1.24; 95% confidence interval [CI] 0.85\u20131.81). Similar results were obtained when we assessed the time to first hospitalization with gastrointestinal bleeding (hazard ratio 1.25, 95% CI 0.87\u20131.79). In conclusion, we found living kidney donation was not associated with a higher risk of hospitalization with gastrointestinal bleeding. These results are reassuring for the safety of the practice.<\/jats:p>","DOI":"10.1111\/ctr.12344","type":"journal-article","created":{"date-parts":[[2014,3,3]],"date-time":"2014-03-03T09:31:23Z","timestamp":1393839083000},"page":"530-539","source":"Crossref","is-referenced-by-count":16,"title":["Risk of serious gastrointestinal bleeding in living kidney donors"],"prefix":"10.1111","volume":"28","author":[{"given":"Sonia M.","family":"Thomas","sequence":"first","affiliation":[{"name":"Department of Epidemiology &amp; Biostatistics Schulich School of Medicine &amp; Dentistry Western University London ON Canada"},{"name":"Division of Nephrology Department of Medicine Western University London ON Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ngan N.","family":"Lam","sequence":"additional","affiliation":[{"name":"Department of Epidemiology &amp; Biostatistics Schulich School of Medicine &amp; Dentistry Western University London ON Canada"},{"name":"Division of Nephrology Department of Medicine Western University London ON Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anjie","family":"Huang","sequence":"additional","affiliation":[{"name":"Institute for Clinical Evaluative Sciences ON Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Danielle M.","family":"Nash","sequence":"additional","affiliation":[{"name":"Division of Nephrology Department of Medicine Western University London ON Canada"},{"name":"Institute for Clinical Evaluative Sciences ON Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G. V.","family":"Prasad","sequence":"additional","affiliation":[{"name":"Division of Nephrology University of Toronto Toronto ON Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gregory A.","family":"Knoll","sequence":"additional","affiliation":[{"name":"Division of Nephrology Kidney Research Centre Ottawa Hospital Research Institute University of Ottawa Ottawa ON Canada"},{"name":"Clinical Epidemiology Program Ottawa Hospital Research Institute Ottawa ON Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John J.","family":"Koval","sequence":"additional","affiliation":[{"name":"Department of Epidemiology &amp; Biostatistics Schulich School of Medicine &amp; Dentistry Western University London ON Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Krista L.","family":"Lentine","sequence":"additional","affiliation":[{"name":"Center for Outcomes Research Saint Louis University St. Louis MO USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S. Joseph","family":"Kim","sequence":"additional","affiliation":[{"name":"Institute for Clinical Evaluative Sciences ON Canada"},{"name":"Division of Nephrology University of Toronto Toronto ON Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ahsan","family":"Alam","sequence":"additional","affiliation":[{"name":"Division of Nephrology McGill University Health Centre Montreal QC Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charmaine E.","family":"Lok","sequence":"additional","affiliation":[{"name":"Division of Nephrology University of Toronto Toronto ON Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Darin J.","family":"Treleaven","sequence":"additional","affiliation":[{"name":"Division of Nephrology Department of Medicine McMaster University Hamilton ON Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amit X.","family":"Garg","sequence":"additional","affiliation":[{"name":"Department of 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