{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,12]],"date-time":"2025-12-12T13:24:46Z","timestamp":1765545886773},"reference-count":23,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2014,6,3]],"date-time":"2014-06-03T00:00:00Z","timestamp":1401753600000},"content-version":"vor","delay-in-days":2,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Transplantation"],"published-print":{"date-parts":[[2014,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Acute rejection (<jats:styled-content style=\"fixed-case\">AR<\/jats:styled-content>) remains a concern for kidney transplantation. Cytokines are key mediators in the induction and effector phases of all immune and inflammatory responses. Single nucleotide polymorphisms (<jats:styled-content style=\"fixed-case\">SNP<\/jats:styled-content>s) in cytokines and their receptors may relate to <jats:styled-content style=\"fixed-case\">AR<\/jats:styled-content>. We investigated the relation between <jats:styled-content style=\"fixed-case\">AR<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">SNP<\/jats:styled-content>s in the genes encoding for <jats:italic><jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u20102<\/jats:italic>(\u2013330G&gt;T), <jats:italic><jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u201010<\/jats:italic>(\u2212592C&gt;A and \u22121082G&gt;A), <jats:italic><jats:styled-content style=\"fixed-case\">TGF<\/jats:styled-content>\u2010<\/jats:italic>\u03b2<jats:italic>1<\/jats:italic>(915G&gt;C), and <jats:italic><jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u20102<jats:styled-content style=\"fixed-case\">RB<\/jats:styled-content><\/jats:italic>(rs228942 C&gt;A and rs228953 C&gt;T) in 325 renal transplant patients during the first year after transplantation. The overall incidence of <jats:styled-content style=\"fixed-case\">AR<\/jats:styled-content> was 15.4%. In multivariate analysis, only the use of induction therapy was correlated with <jats:styled-content style=\"fixed-case\">AR<\/jats:styled-content> (odds ratio 1.9; 95% confidence interval 1.1\u20133.7; p\u00a0=\u00a00.04). No statistically significant associations between the <jats:styled-content style=\"fixed-case\">SNP<\/jats:styled-content>s studied and <jats:styled-content style=\"fixed-case\">AR<\/jats:styled-content> were observed. <jats:styled-content style=\"fixed-case\">SNP<\/jats:styled-content>s in the investigated cytokines and their receptors were not associated with the risk of <jats:styled-content style=\"fixed-case\">AR<\/jats:styled-content>. Genotyping patients for these <jats:styled-content style=\"fixed-case\">SNP<\/jats:styled-content>s is unlikely to aid the clinician in adjusting the immunosuppressive therapy for individual patients.<\/jats:p>","DOI":"10.1111\/ctr.12346","type":"journal-article","created":{"date-parts":[[2014,3,3]],"date-time":"2014-03-03T09:31:22Z","timestamp":1393839082000},"page":"649-655","source":"Crossref","is-referenced-by-count":17,"title":["Genetic polymorphisms in <i><scp>IL<\/scp>\u20102<\/i>,<i><scp>IL<\/scp>\u201010<\/i>,<i><scp>TGF<\/scp>\u2010<\/i>\u03b2<i>1<\/i>, and <i><scp>IL<\/scp>\u20102<scp>RB<\/scp><\/i> and acute rejection in renal transplant patients"],"prefix":"10.1111","volume":"28","author":[{"given":"Zhigang","family":"Chen","sequence":"first","affiliation":[{"name":"Department of Hospital Pharmacy Erasmus MC Rotterdam The Netherlands"},{"name":"Department of Hospital Pharmacy Beijing Jishuitan Hospital Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rachida","family":"Bouamar","sequence":"additional","affiliation":[{"name":"Department of Hospital Pharmacy Erasmus MC Rotterdam The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ron H.N.","family":"Van schaik","sequence":"additional","affiliation":[{"name":"Department of Clinical Chemistry Erasmus MC Rotterdam The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Johan W.","family":"De Fijter","sequence":"additional","affiliation":[{"name":"Department of Nephrology Leiden University Medical Centre Leiden The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anders","family":"Hartmann","sequence":"additional","affiliation":[{"name":"Department of Transplant Medicine Oslo University Hospital Rikshospitalet Norway"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Martin","family":"Zeier","sequence":"additional","affiliation":[{"name":"Department of Nephrology University of Heidelberg Heidelberg Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Klemens","family":"Budde","sequence":"additional","affiliation":[{"name":"Department of Nephrology Charit\u00e9 University Berlin Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dirk R.J.","family":"Kuypers","sequence":"additional","affiliation":[{"name":"Department of Nephrology University of Leuven Leuven Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Willem","family":"Weimar","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Erasmus MC Rotterdam The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dennis A.","family":"Hesselink","sequence":"additional","affiliation":[{"name":"Department of Internal 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