{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,10]],"date-time":"2026-03-10T13:11:16Z","timestamp":1773148276269,"version":"3.50.1"},"reference-count":21,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2014,4,21]],"date-time":"2014-04-21T00:00:00Z","timestamp":1398038400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Transplantation"],"published-print":{"date-parts":[[2014,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:label\/><jats:p>Vitamin D deficiency is common among patients with end\u2010stage liver disease (<jats:styled-content style=\"fixed-case\">ESLD<\/jats:styled-content>). The primary aim of our study was to assess the prevalence of vitamin D deficiency, secondary hyperparathyroidism, and bone disease in patients with <jats:styled-content style=\"fixed-case\">ESLD<\/jats:styled-content> awaiting <jats:styled-content style=\"fixed-case\">LT<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We retrospectively studied 190 patients at our center. Serum total 25\u2010hydroxyvitamin D (25\u2010<jats:styled-content style=\"fixed-case\">OH<\/jats:styled-content> D), parathyroid hormone (<jats:styled-content style=\"fixed-case\">PTH<\/jats:styled-content>), calcium, and bone mineral analysis (<jats:styled-content style=\"fixed-case\">BMA<\/jats:styled-content>) were recorded. Standard World Health Organization (<jats:styled-content style=\"fixed-case\">WHO<\/jats:styled-content>) criteria were used to diagnose osteopenia\/osteoporosis. Only patients with normal serum creatinine were analyzed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Thirty\u2010two of 190 patients were excluded from the final analysis (missing serum total 25\u2010OH D levels in three patients and elevated serum creatinine, 29 patients). 105 of 158 (66.4%) evaluable patients had 25\u2010OH D levels &lt;25\u00a0ng\/mL. Patients included in the analysis (n\u00a0=\u00a0158) were divided according to serum total 25\u2010OH D levels: 0\u201310\u00a0ng\/mL (n\u00a0=\u00a023), 11\u201320\u00a0ng\/mL (n\u00a0=\u00a064), and &gt;20\u00a0ng\/mL (n\u00a0=\u00a071). There were no significant differences in mean serum PTH and corrected calcium levels among the three subgroups. Only three patients had elevated serum PTH. Patients with total 25\u2010OH D\u00a0\u2264\u00a010\u00a0ng\/mL had higher model for end\u2010stage liver disease (MELD) scores vs. those with 25\u2010OH D\u00a0&gt;\u00a020\u00a0ng\/mL (13.3\u00a0\u00b1\u00a03, range 8\u201321, vs. 11.9\u00a0\u00b1\u00a03.4, range 6\u201329, p\u00a0=\u00a00.004). Irrespective of vitamin D status, bone disease was present in 64.6% of patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Low vitamin D levels and bone disease are common among patients with <jats:styled-content style=\"fixed-case\">ESLD<\/jats:styled-content> awaiting <jats:styled-content style=\"fixed-case\">LT<\/jats:styled-content>. Despite a high prevalence of low serum total 25\u2010<jats:styled-content style=\"fixed-case\">OH<\/jats:styled-content> D, our cohort maintained normal corrected calcium levels and did not develop secondary hyperparathyroidism. We propose that free serum 25\u2010<jats:styled-content style=\"fixed-case\">OH<\/jats:styled-content> D and vitamin D\u2010binding protein may be necessary to accurately establish the diagnosis of vitamin D deficiency in the setting of <jats:styled-content style=\"fixed-case\">ESLD<\/jats:styled-content>. Additional studies are needed to further define mechanisms of bone disease in patients with <jats:styled-content style=\"fixed-case\">ESLD<\/jats:styled-content>.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ctr.12351","type":"journal-article","created":{"date-parts":[[2014,3,13]],"date-time":"2014-03-13T17:42:45Z","timestamp":1394732565000},"page":"579-584","source":"Crossref","is-referenced-by-count":32,"title":["Vitamin D deficiency, parathyroid hormone levels, and bone disease among patients with end\u2010stage liver disease and normal serum creatinine awaiting liver transplantation"],"prefix":"10.1111","volume":"28","author":[{"given":"Rebecca L.","family":"Corey","sequence":"first","affiliation":[{"name":"Transplantation Center Mayo Clinic Hospital Phoenix AZ USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael D.","family":"Whitaker","sequence":"additional","affiliation":[{"name":"Division of Endocrinology Mayo Clinic Phoenix AZ USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael D.","family":"Crowell","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology Mayo Clinic Phoenix AZ USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mira T.","family":"Keddis","sequence":"additional","affiliation":[{"name":"Division of Nephrology Mayo Clinic Phoenix AZ USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bashar","family":"Aqel","sequence":"additional","affiliation":[{"name":"Transplantation Center Mayo Clinic Hospital Phoenix AZ USA"},{"name":"Division of Gastroenterology and Hepatology Mayo Clinic Phoenix AZ USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vijayan","family":"Balan","sequence":"additional","affiliation":[{"name":"Transplantation Center Mayo Clinic Hospital Phoenix AZ USA"},{"name":"Division of Gastroenterology and Hepatology Mayo Clinic Phoenix AZ USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas","family":"Byrne","sequence":"additional","affiliation":[{"name":"Transplantation Center Mayo Clinic Hospital Phoenix AZ USA"},{"name":"Division of Gastroenterology and Hepatology Mayo Clinic Phoenix AZ USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elizabeth","family":"Carey","sequence":"additional","affiliation":[{"name":"Transplantation Center Mayo Clinic Hospital Phoenix AZ USA"},{"name":"Division of Gastroenterology and Hepatology Mayo Clinic Phoenix AZ USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David D.","family":"Douglas","sequence":"additional","affiliation":[{"name":"Transplantation Center Mayo Clinic Hospital Phoenix AZ USA"},{"name":"Division of Gastroenterology and Hepatology Mayo Clinic Phoenix AZ USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M. Edwyn","family":"Harrison","sequence":"additional","affiliation":[{"name":"Transplantation Center Mayo Clinic Hospital Phoenix AZ USA"},{"name":"Division of Gastroenterology and Hepatology Mayo Clinic Phoenix AZ USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hugo E.","family":"Vargas","sequence":"additional","affiliation":[{"name":"Transplantation Center Mayo Clinic Hospital Phoenix AZ USA"},{"name":"Division of Gastroenterology and Hepatology Mayo Clinic Phoenix AZ USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jorge","family":"Rakela","sequence":"additional","affiliation":[{"name":"Transplantation Center Mayo Clinic Hospital Phoenix AZ USA"},{"name":"Division of Gastroenterology and Hepatology Mayo Clinic Phoenix AZ USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2014,4,21]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra070553"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2010020186"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.18553\/jmcp.2007.13.5.397"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ecl.2010.02.008"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2012.04.033"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.2340\/00015555-0980"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1746.2011.06746.x"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11894-011-0231-7"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/lt.23646"},{"issue":"4","key":"e_1_2_7_11_1","first-page":"945A","article-title":"Vitamin D, A, and E deficiencies among patients with end stage liver disease (ESLD) awaiting liver transplantation (LT)","volume":"56","author":"Corey R","year":"2012","journal-title":"Hepatology"},{"issue":"4","key":"e_1_2_7_12_1","first-page":"941A","article-title":"Vitamin D deficiency, parathyroid hormone (PTH) levels, and bone disease among patients with end stage liver disease (ESLD) awaiting liver transplantation (LT)","volume":"56","author":"Corey R","year":"2012","journal-title":"Hepatology"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2006.10.015"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.21563"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1053\/jhep.2001.22172"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1746.1996.tb00284.x"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI112636"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1478-3231.2011.02638.x"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2009121293"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1038\/ki.2011.47"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1359\/JBMR.0301264"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrgastro.2009.166"}],"container-title":["Clinical Transplantation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fctr.12351","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ctr.12351","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,24]],"date-time":"2023-09-24T06:44:36Z","timestamp":1695537876000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/ctr.12351"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,4,21]]},"references-count":21,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2014,5]]}},"alternative-id":["10.1111\/ctr.12351"],"URL":"https:\/\/doi.org\/10.1111\/ctr.12351","archive":["Portico"],"relation":{},"ISSN":["0902-0063","1399-0012"],"issn-type":[{"value":"0902-0063","type":"print"},{"value":"1399-0012","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,4,21]]}}}