{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,10]],"date-time":"2026-03-10T03:35:02Z","timestamp":1773113702326,"version":"3.50.1"},"reference-count":33,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2014,5,8]],"date-time":"2014-05-08T00:00:00Z","timestamp":1399507200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Transplantation"],"published-print":{"date-parts":[[2014,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Recent studies have shown that single\u2010nucleotide polymorphisms (<jats:styled-content style=\"fixed-case\">SNP<\/jats:styled-content>s) are associated with allograft rejection in kidney transplantation recipients. We evaluated the possible association between <jats:styled-content style=\"fixed-case\">SNP<\/jats:styled-content>s of the cytochrome P450, family 2, subfamily E, polypeptide 1 (<jats:italic><jats:styled-content style=\"fixed-case\">CYP<\/jats:styled-content>2E1<\/jats:italic>) gene, and acute rejection (<jats:styled-content style=\"fixed-case\">AR<\/jats:styled-content>) among renal transplant patients in a Korean population. We conducted a case\u2013control association study in 63 <jats:styled-content style=\"fixed-case\">AR<\/jats:styled-content> and 284 non\u2010<jats:styled-content style=\"fixed-case\">AR<\/jats:styled-content> kidney transplant recipients. The <jats:styled-content style=\"fixed-case\">SNP<\/jats:styled-content>s of <jats:italic><jats:styled-content style=\"fixed-case\">CYP<\/jats:styled-content>2E1<\/jats:italic> were genotyped by direct sequencing. Recipient sex (p\u00a0=\u00a00.023) and the use of tacrolimus (p\u00a0=\u00a00.017) were significantly different between the two groups. The use of mycophenolate mofetil (<jats:styled-content style=\"fixed-case\">MMF<\/jats:styled-content>) and antibody induction therapy was significantly lower in the <jats:styled-content style=\"fixed-case\">AR<\/jats:styled-content> group. Multiple logistic regression models (codominant, dominant, recessive, and log\u2010additive models) adjusted by sex and type of immunosuppressive regimens were applied to determine the odds ratios (<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content>s), 95% confidence intervals (<jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>s), and p\u2010values. The rs2515641 of <jats:styled-content style=\"fixed-case\">CYP<\/jats:styled-content>2E1 showed significant differences between the <jats:styled-content style=\"fixed-case\">AR<\/jats:styled-content> patient group and non\u2010<jats:styled-content style=\"fixed-case\">AR<\/jats:styled-content> group (p\u00a0=\u00a00.003, <jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content>\u00a0=\u00a02.55, 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>\u00a0=\u00a01.37\u20134.75 in the codominant 1 model; p\u00a0=\u00a00.002, <jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content>\u00a0=\u00a02.61, 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>\u00a0=\u00a01.43\u20134.77 in the dominant model; p\u00a0=\u00a00.0035, <jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content>\u00a0=\u00a02.13, 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>\u00a0=\u00a01.29\u20133.50 in the log\u2010additive model). The allele of the rs2515641 <jats:styled-content style=\"fixed-case\">SNP<\/jats:styled-content> also showed a significant association (p\u00a0=\u00a00.004, <jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content>\u00a0=\u00a01.99, 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>\u00a0=\u00a01.24\u20133.21). This study suggests that the <jats:italic><jats:styled-content style=\"fixed-case\">CYP<\/jats:styled-content>2E1<\/jats:italic> polymorphism may be related to the development of <jats:styled-content style=\"fixed-case\">AR<\/jats:styled-content> in Korean kidney transplantation recipients.<\/jats:p>","DOI":"10.1111\/ctr.12369","type":"journal-article","created":{"date-parts":[[2014,3,22]],"date-time":"2014-03-22T14:48:55Z","timestamp":1395499735000},"page":"707-712","source":"Crossref","is-referenced-by-count":9,"title":["Association studies of cytochrome P450, family 2, subfamily E, polypeptide 1 (<i><scp>CYP<\/scp>2E1<\/i>) gene polymorphisms with acute rejection in kidney transplantation recipients"],"prefix":"10.1111","volume":"28","author":[{"given":"Su Kang","family":"Kim","sequence":"first","affiliation":[{"name":"Kohwang Medical Research Institute School of Medicine Kyung Hee University Seoul Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hae Jeong","family":"Park","sequence":"additional","affiliation":[{"name":"Kohwang Medical Research Institute School of Medicine Kyung Hee University Seoul Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hosik","family":"Seok","sequence":"additional","affiliation":[{"name":"Kohwang Medical Research Institute School of Medicine Kyung Hee University Seoul Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hye Sook","family":"Jeon","sequence":"additional","affiliation":[{"name":"Kohwang Medical Research Institute School of Medicine Kyung Hee University Seoul Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tae Won","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Nephrology School of Medicine Kyung Hee University Seoul Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sang Ho","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Nephrology School of Medicine Kyung Hee University Seoul Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ju Young","family":"Moon","sequence":"additional","affiliation":[{"name":"Department of Nephrology School of Medicine Kyung Hee University Seoul Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chun Gyoo","family":"Ihm","sequence":"additional","affiliation":[{"name":"Department of Nephrology School of Medicine Kyung Hee University Seoul Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tae Hee","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Nephrology School of Medicine Inje University Busan Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yeong Hoon","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Nephrology School of Medicine Inje University Busan Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sun Woo","family":"Kang","sequence":"additional","affiliation":[{"name":"Department of Nephrology School of Medicine Inje University Busan Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Seok Ju","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Nephrology School of Medicine Inje University Busan Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kyung Hwan","family":"Jeong","sequence":"additional","affiliation":[{"name":"Department of Nephrology School of Medicine Kyung Hee University Seoul Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joo\u2010Ho","family":"Chung","sequence":"additional","affiliation":[{"name":"Kohwang Medical Research Institute School of Medicine Kyung Hee University Seoul Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2014,5,8]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-12-398339-8.00004-5"},{"key":"e_1_2_6_3_1","first-page":"4233","article-title":"CYP3A4 genetic polymorphisms predict cyclosporine\u2010related clinical events in Chinese renal transplant recipients","volume":"125","author":"Wang YY","year":"2013","journal-title":"Chin Med J 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