{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,12]],"date-time":"2026-06-12T05:34:41Z","timestamp":1781242481794,"version":"3.54.1"},"reference-count":35,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2014,5,21]],"date-time":"2014-05-21T00:00:00Z","timestamp":1400630400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Transplantation"],"published-print":{"date-parts":[[2014,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Non\u2010infectious pulmonary complications following hematopoietic stem cell transplantation (<jats:styled-content style=\"fixed-case\">HSCT<\/jats:styled-content>) are major cause of morbidity and mortality with limited treatment options. Lung transplantation (<jats:styled-content style=\"fixed-case\">LT<\/jats:styled-content>) has been rarely reported as a treatment option for selected <jats:styled-content style=\"fixed-case\">HSCT<\/jats:styled-content> recipients with these problems.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>Describe the outcome of HSCT recipients who underwent LT.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Two cases of <jats:styled-content style=\"fixed-case\">LT<\/jats:styled-content> following <jats:styled-content style=\"fixed-case\">HSCT<\/jats:styled-content> from our institution are presented. Cases reported in literature were identified using English language PubMed\/MEDLINE with keywords hematopoietic stem cell transplantation, bone marrow transplantation, or bronchiolitis obliterans cross\u2010referenced with lung transplantation. We extracted data on baseline characteristics and survival data following <jats:styled-content style=\"fixed-case\">LT<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Total of 84 patients are analyzed. Age at time of <jats:styled-content style=\"fixed-case\">LT<\/jats:styled-content> was median of 22\u00a0yr (range 1\u201366). Seventy\u2010nine patients were recipients of allogeneic <jats:styled-content style=\"fixed-case\">HSCT<\/jats:styled-content>. The indications for <jats:styled-content style=\"fixed-case\">LT<\/jats:styled-content> were bronchiolitis obliterans syndrome (<jats:styled-content style=\"fixed-case\">BOS<\/jats:styled-content>; 63 patients), pulmonary fibrosis (13 patients), <jats:styled-content style=\"fixed-case\">BOS<\/jats:styled-content>\/pulmonary fibrosis (five patients), and graft\u2010versus\u2010host\u2010disease (<jats:styled-content style=\"fixed-case\">GVHD<\/jats:styled-content>) of lung (three patients). The median time between <jats:styled-content style=\"fixed-case\">HSCT<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">LT<\/jats:styled-content> was 52.3\u00a0months (range 6\u2013240). The median follow\u2010up after <jats:styled-content style=\"fixed-case\">LT<\/jats:styled-content> was 36\u00a0months (range 0\u2013168). During this time, <jats:styled-content style=\"fixed-case\">BOS<\/jats:styled-content> was documented in 25 patients. Relapse of hematological malignancy was reported in two patients, and new malignancy developed in four patients. At the end of follow\u2010up, 60 patients were alive and 24 patients died. The probability of survival following <jats:styled-content style=\"fixed-case\">LT<\/jats:styled-content> at 24 and 36\u00a0months was 0.88 (95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> 0.78\u20130.93) and 0.79 (95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> 0.67\u20130.87), respectively.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p><jats:styled-content style=\"fixed-case\">LT<\/jats:styled-content> is a potential therapeutic option in selected patients with severe chronic pulmonary disease following <jats:styled-content style=\"fixed-case\">HSCT<\/jats:styled-content>. Further studies are needed to determine the appropriate timing and the outcome of this approach.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ctr.12378","type":"journal-article","created":{"date-parts":[[2014,4,23]],"date-time":"2014-04-23T10:18:12Z","timestamp":1398248292000},"page":"776-782","source":"Crossref","is-referenced-by-count":38,"title":["Lung transplantation following hematopoietic stem cell transplantation: report of two cases and systematic review of literature"],"prefix":"10.1111","volume":"28","author":[{"given":"Ayman O.","family":"Soubani","sequence":"first","affiliation":[{"name":"Division of Pulmonary, Critical Care and Sleep Medicine Karmanos Cancer Center School of Medicine Wayne State University Detroit MI USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pascal","family":"Kingah","sequence":"additional","affiliation":[{"name":"Division of Pulmonary, Critical Care and Sleep Medicine Karmanos Cancer Center School of Medicine Wayne State University Detroit MI USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Khaled","family":"Alshabani","sequence":"additional","affiliation":[{"name":"Division of Pulmonary, Critical Care and Sleep Medicine Karmanos Cancer Center School of Medicine Wayne State University Detroit MI USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gilbert","family":"Muma","sequence":"additional","affiliation":[{"name":"Astellas Pharma Inc Chicago IL USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Athar","family":"Haq","sequence":"additional","affiliation":[{"name":"Division of Pulmonary, Critical Care and Sleep Medicine Karmanos Cancer Center School of Medicine Wayne State University Detroit MI USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2014,5,21]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1004383"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1378\/chest.12-1708"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1658-3876(10)50025-6"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-0012.2009.01122.x"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2002-10-3289"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbmt.2007.05.001"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.00052806"},{"key":"e_1_2_5_9_1","doi-asserted-by":"crossref","first-page":"948","DOI":"10.1378\/chest.102.3.948","article-title":"Lung transplantation in a patient with a prior bone marrow transplant","volume":"102","author":"Calhoon JH","year":"1992","journal-title":"Chest"},{"key":"e_1_2_5_10_1","doi-asserted-by":"crossref","first-page":"1584","DOI":"10.1378\/chest.105.5.1584","article-title":"Pediatric lung transplantation for graft\u2010versus\u2010host disease following bone marrow transplantation","volume":"105","author":"Boas SR","year":"1994","journal-title":"Chest"},{"key":"e_1_2_5_11_1","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1378\/chest.105.1.327a","article-title":"Lung transplants in patients with prior bone marrow transplants","volume":"105","author":"Gascoigne A","year":"1994","journal-title":"Chest"},{"key":"e_1_2_5_12_1","first-page":"388","article-title":"Transplantation of a lobe of lung from mother to child following previous transplantation with maternal bone marrow","volume":"18","author":"Svendsen UG","year":"1999","journal-title":"J Heart Lung Transplant"},{"key":"e_1_2_5_13_1","doi-asserted-by":"crossref","first-page":"1986","DOI":"10.1097\/00007890-200112270-00020","article-title":"Lung transplantation after allogeneic marrow transplantation in pediatric patients: the Memorial Sloan\u2010Kettering experience","volume":"72","author":"Heath JA","year":"2001","journal-title":"Transplantation"},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1053-2498(02)00671-X"},{"key":"e_1_2_5_15_1","doi-asserted-by":"crossref","first-page":"1051","DOI":"10.1016\/j.athoracsur.2003.09.111","article-title":"Living\u2010donor lobar lung transplantation for bronchiolitis obliterans after bone marrow transplantation","volume":"79","author":"Sano Y","year":"2005","journal-title":"Ann Thorac Surg"},{"key":"e_1_2_5_16_1","doi-asserted-by":"publisher","DOI":"10.1532\/IJH97.07045"},{"key":"e_1_2_5_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtcvs.2007.03.063"},{"key":"e_1_2_5_18_1","doi-asserted-by":"publisher","DOI":"10.1097\/TP.0b013e318190b0be"},{"key":"e_1_2_5_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.21647"},{"key":"e_1_2_5_20_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12185-009-0436-9"},{"key":"e_1_2_5_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.transproceed.2010.07.086"},{"key":"e_1_2_5_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-3046.2010.01401.x"},{"key":"e_1_2_5_23_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-0012.2009.01155.x"},{"key":"e_1_2_5_24_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-6143.2010.03187.x"},{"key":"e_1_2_5_25_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-0012.2011.01482.x"},{"key":"e_1_2_5_26_1","doi-asserted-by":"publisher","DOI":"10.3349\/ymj.2012.53.5.1054"},{"key":"e_1_2_5_27_1","doi-asserted-by":"publisher","DOI":"10.1097\/TP.0b013e31829df2c0"},{"key":"e_1_2_5_28_1","doi-asserted-by":"publisher","DOI":"10.1111\/petr.12023"},{"key":"e_1_2_5_29_1","doi-asserted-by":"publisher","DOI":"10.1097\/TP.0b013e318277e29e"},{"key":"e_1_2_5_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.healun.2006.03.011"},{"key":"e_1_2_5_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbmt.2009.10.023"},{"key":"e_1_2_5_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.healun.2012.08.004"},{"key":"e_1_2_5_33_1","unstructured":"PasquiniMC WangZ.Current use and outcome of hematopoietic stem cell transplantation: CIBMTR Summary Slides. Available at:http:\/\/www.cibmtr.org 2012."},{"key":"e_1_2_5_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.healun.2011.08.004"},{"key":"e_1_2_5_35_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-6143.2011.03591.x"},{"key":"e_1_2_5_36_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2010.885"}],"container-title":["Clinical Transplantation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fctr.12378","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ctr.12378","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,3]],"date-time":"2023-10-03T20:30:11Z","timestamp":1696365011000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/ctr.12378"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,5,21]]},"references-count":35,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2014,7]]}},"alternative-id":["10.1111\/ctr.12378"],"URL":"https:\/\/doi.org\/10.1111\/ctr.12378","archive":["Portico"],"relation":{},"ISSN":["0902-0063","1399-0012"],"issn-type":[{"value":"0902-0063","type":"print"},{"value":"1399-0012","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,5,21]]}}}