{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T09:31:40Z","timestamp":1789723900863,"version":"4.0.1"},"reference-count":22,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2014,5,29]],"date-time":"2014-05-29T00:00:00Z","timestamp":1401321600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Transplantation"],"published-print":{"date-parts":[[2014,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>Acute graft failure is the leading cause of early mortality after heart transplantation (<jats:styled-content style=\"fixed-case\">HTx<\/jats:styled-content>). Extracorporeal membrane oxygenation (<jats:styled-content style=\"fixed-case\">ECMO<\/jats:styled-content>) is an efficient therapeutic option to treat various pathologies, unburden the left and right ventricle, and allow for functional recovery of the transplanted heart. We reviewed our <jats:styled-content style=\"fixed-case\">ECMO<\/jats:styled-content> experience and outcomes in <jats:styled-content style=\"fixed-case\">HTx<\/jats:styled-content> patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Retrospectively, we analyzed all patients who received an orthotopic <jats:styled-content style=\"fixed-case\">HT<\/jats:styled-content>x (n\u00a0=\u00a0298) in our department over a 15\u2010yr period (1997 through 2011) to assess the incidence of post\u2010<jats:styled-content style=\"fixed-case\">HT<\/jats:styled-content>x <jats:styled-content style=\"fixed-case\">ECMO<\/jats:styled-content> implantation, perioperative complications, early and one\u2010yr mortality as well as causes of death.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p><jats:styled-content style=\"fixed-case\">ECMO<\/jats:styled-content> therapy was utilized to treat graft failure in 28 patients (10.6%) with a mean duration of <jats:styled-content style=\"fixed-case\">ECMO<\/jats:styled-content> support of 4.2\u00a0d (six\u00a0h to 9.4\u00a0d). Multivariate analysis revealed as independent predictors for mortality low cardiac output (p\u00a0=\u00a00.028; odds ratio (<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content>)\u00a0=\u00a011.3) and stroke (p\u00a0=\u00a00.008; <jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content>\u00a0=\u00a019.7). Cumulative survival rates were 46.4\u00a0\u00b1\u00a09.4% within 30\u00a0d and 25.0\u00a0\u00b1\u00a08.2% at one\u00a0yr. Causes of death were multiorgan failure (n\u00a0=\u00a09), sepsis (n\u00a0=\u00a09), lung failure (n\u00a0=\u00a02), and intracerebral bleeding (n\u00a0=\u00a02). <jats:styled-content style=\"fixed-case\">ECMO<\/jats:styled-content> was implanted due to primary graft failure (<jats:styled-content style=\"fixed-case\">PGF<\/jats:styled-content>, n\u00a0=\u00a016), sepsis (n\u00a0=\u00a04), and right heart failure (n\u00a0=\u00a06).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Temporary <jats:styled-content style=\"fixed-case\">ECMO<\/jats:styled-content> support for postoperative output failure is an acceptable option as a last resort for otherwise doomed patients with fatal graft failure after <jats:styled-content style=\"fixed-case\">HT<\/jats:styled-content>x. The small fraction of patients surviving appear to have a decent long\u2010term prognosis.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ctr.12380","type":"journal-article","created":{"date-parts":[[2014,4,29]],"date-time":"2014-04-29T09:48:29Z","timestamp":1398764909000},"page":"789-796","source":"Crossref","is-referenced-by-count":14,"title":["Extracorporeal membrane oxygenation: experience in acute graft failure after heart transplantation"],"prefix":"10.1111","volume":"28","author":[{"given":"Sven","family":"Lehmann","sequence":"first","affiliation":[{"name":"Department of Cardiac Surgery Heart Center Leipzig University of Leipzig Leipzig Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Madlen","family":"Uhlemann","sequence":"additional","affiliation":[{"name":"Department of Cardiology Heart Center Leipzig University of Leipzig Leipzig Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian D.","family":"Etz","sequence":"additional","affiliation":[{"name":"Department of Cardiac Surgery Heart Center Leipzig University of Leipzig Leipzig Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jens","family":"Garbade","sequence":"additional","affiliation":[{"name":"Department of Cardiac Surgery Heart Center Leipzig University of Leipzig Leipzig Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Schroeter","sequence":"additional","affiliation":[{"name":"Department of Cardiac Surgery Heart Center Leipzig University of Leipzig Leipzig Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Borger","sequence":"additional","affiliation":[{"name":"Department of Cardiac Surgery Heart Center Leipzig University of Leipzig Leipzig Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin","family":"Misfeld","sequence":"additional","affiliation":[{"name":"Department of Cardiac Surgery Heart Center Leipzig University of Leipzig Leipzig Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hartmuth B.","family":"Bittner","sequence":"additional","affiliation":[{"name":"Department of Cardiac Surgery Heart Center Leipzig University of Leipzig Leipzig Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Friedrich Wilhelm","family":"Mohr","sequence":"additional","affiliation":[{"name":"Department of Cardiac Surgery Heart Center Leipzig University of Leipzig Leipzig 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