{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T21:22:51Z","timestamp":1792099371550,"version":"4.4.0"},"reference-count":18,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2014,6,24]],"date-time":"2014-06-24T00:00:00Z","timestamp":1403568000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Transplantation"],"published-print":{"date-parts":[[2014,8]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Recurrent glomerulonephritis is an important cause of kidney allograft failure. The effect of immunosuppression on recurrent IgA nephropathy (Ig\n                    <jats:styled-content style=\"fixed-case\">AN<\/jats:styled-content>\n                    ) is unclear. We analyzed the impact of steroids and other immunosuppression on the risk of recurrent Ig\n                    <jats:styled-content style=\"fixed-case\">AN<\/jats:styled-content>\n                    post\u2010kidney transplantation. Between June 1989 and November 2008, 3311 kidney transplants were performed at our center. Ig\n                    <jats:styled-content style=\"fixed-case\">AN<\/jats:styled-content>\n                    was the primary disease in 124 patients; of these, 75 (60.5%) patients received steroid\u2010based immunosuppression (15 undergoing late steroid withdrawal), and 49 (39.5%) were maintained on steroid\u2010free immunosuppression. Recurrent Ig\n                    <jats:styled-content style=\"fixed-case\">AN<\/jats:styled-content>\n                    was diagnosed in 27 of 124 (22%) patients in clinically indicated kidney allograft biopsies over a median follow\u2010up of 6.86\u00a0\u00b1\u00a05.4\u00a0yr. On cox proportional hazards model multivariate analysis, the hazard risk (\n                    <jats:styled-content style=\"fixed-case\">HR<\/jats:styled-content>\n                    ) of Ig\n                    <jats:styled-content style=\"fixed-case\">AN<\/jats:styled-content>\n                    recurrence was significantly higher in patients managed with steroid\u2010free (\n                    <jats:styled-content style=\"fixed-case\">HR<\/jats:styled-content>\n                    8.59: 3.03, 24.38, p\u00a0&lt;\u00a00.001) and sirolimus\u2010based (\n                    <jats:styled-content style=\"fixed-case\">HR<\/jats:styled-content>\n                    \u00a0=\u00a03.00:1.16, 7.75, p\u00a0=\u00a00.024) immunosuppression without antilymphocyte globulin induction (\n                    <jats:styled-content style=\"fixed-case\">HR<\/jats:styled-content>\n                    \u00a0=\u00a04.5: 1.77, 11.73, p\u00a0=\u00a00.002). Mycophenolate use was associated with a lower risk (\n                    <jats:styled-content style=\"fixed-case\">HR<\/jats:styled-content>\n                    \u00a0=\u00a00.42: 0.19, 0.95, p\u00a0=\u00a00.036), whereas cyclosporine did not have a significant impact on the risk of Ig\n                    <jats:styled-content style=\"fixed-case\">AN<\/jats:styled-content>\n                    recurrence (p\u00a0=\u00a00.61). These results warrant future prospective studies regarding the role of steroids and other immunosuppression drugs in reducing recurrence of Ig\n                    <jats:styled-content style=\"fixed-case\">AN<\/jats:styled-content>\n                    and other glomerulonephritis post\u2010transplant.\n                  <\/jats:p>","DOI":"10.1111\/ctr.12389","type":"journal-article","created":{"date-parts":[[2014,5,28]],"date-time":"2014-05-28T09:18:09Z","timestamp":1401268689000},"page":"845-854","source":"Crossref","is-referenced-by-count":46,"title":["The risk of recurrent\n                    <scp>I<\/scp>\n                    g\n                    <scp>A<\/scp>\n                    nephropathy in a steroid\u2010free protocol and other modifying immunosuppression"],"prefix":"10.1111","volume":"28","author":[{"given":"J. R.","family":"Von Visger","sequence":"first","affiliation":[{"name":"Division of Nephrology Department of Internal Medicine The Ohio State University College of Medicine and Public Health Columbus OH USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Y.","family":"Gunay","sequence":"additional","affiliation":[{"name":"Division of Transplantation Department of Surgery The Ohio State University College of Medicine and Public Health Columbus OH USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K. A.","family":"Andreoni","sequence":"additional","affiliation":[{"name":"Division of Transplantation Department of Surgery The Ohio State University College of Medicine and Public Health Columbus OH USA"},{"name":"Division of Transplantation Department of Surgery University of Florida Gainesville FL USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"U. Y.","family":"Bhatt","sequence":"additional","affiliation":[{"name":"Division of Nephrology Department of Internal Medicine The Ohio State University College of Medicine and Public Health Columbus OH USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"U. S.","family":"Nori","sequence":"additional","affiliation":[{"name":"Division of Nephrology Department of Internal Medicine The Ohio State University College of Medicine and Public Health Columbus OH USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T. E.","family":"Pesavento","sequence":"additional","affiliation":[{"name":"Division of Nephrology Department of Internal Medicine The Ohio State University College of Medicine and Public Health Columbus OH USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E. A.","family":"Elkhammas","sequence":"additional","affiliation":[{"name":"Division of Transplantation Department of Surgery The Ohio State University College of Medicine and Public Health Columbus OH USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H. A.","family":"Winters","sequence":"additional","affiliation":[{"name":"Department of Pharmacy The Ohio State University College of Medicine and Public Health Columbus OH USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T.","family":"Nadasdy","sequence":"additional","affiliation":[{"name":"Department of Pathology The Ohio State University College of Medicine and Public Health Columbus OH USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N.","family":"Singh","sequence":"additional","affiliation":[{"name":"Division of Nephrology Department of Medicine Louisiana State University Health Sciences Center Shreveport LA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2014,6,24]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra020109"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/00007890-199711270-00024"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa013036"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gfg373"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.semnephrol.2004.01.008"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.transproceed.2004.05.044"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-6143.2006.01502.x"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1097\/TP.0b013e3181705ad4"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gfp356"},{"key":"e_1_2_6_11_1","first-page":"CD005632","article-title":"Steroid avoidance or withdrawal for kidney transplant recipients","volume":"1","author":"Pascual J","year":"2009","journal-title":"Cochrane Database Syst Rev"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1097\/TP.0b013e31821bf157"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-6143.2011.03667.x"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-0012.2006.00521.x"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.ASN.0000103869.08096.4F"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1159\/000226129"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-6143.2010.03306.x"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-6143.2009.02832.x"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-6143.2010.03302.x"}],"container-title":["Clinical Transplantation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fctr.12389","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ctr.12389","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,3]],"date-time":"2023-10-03T12:35:34Z","timestamp":1696336534000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/ctr.12389"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,6,24]]},"references-count":18,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2014,8]]}},"alternative-id":["10.1111\/ctr.12389"],"URL":"https:\/\/doi.org\/10.1111\/ctr.12389","archive":["Portico"],"relation":{},"ISSN":["0902-0063","1399-0012"],"issn-type":[{"value":"0902-0063","type":"print"},{"value":"1399-0012","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,6,24]]}}}