{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,17]],"date-time":"2026-04-17T04:27:02Z","timestamp":1776400022121,"version":"3.51.2"},"reference-count":42,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2014,7,3]],"date-time":"2014-07-03T00:00:00Z","timestamp":1404345600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Transplantation"],"published-print":{"date-parts":[[2014,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Kidney outcomes in early post\u2010liver transplantation (<jats:styled-content style=\"fixed-case\">LT<\/jats:styled-content>) are crucial for long\u2010term prognosis, but difficult to predict. Among 203 adult <jats:styled-content style=\"fixed-case\">LT<\/jats:styled-content> patients, we studied the value of plasma neutrophil gelatinase\u2010associated lipocalin (<jats:styled-content style=\"fixed-case\">NGAL<\/jats:styled-content>) measured pre\u2010<jats:styled-content style=\"fixed-case\">LT<\/jats:styled-content> for predicting acute kidney injury (<jats:styled-content style=\"fixed-case\">AKI<\/jats:styled-content>), kidney\u2010replacement therapy within three\u00a0months, and kidney dysfunction at three\u00a0months post\u2010<jats:styled-content style=\"fixed-case\">LT<\/jats:styled-content>. Glomerular filtration rate (<jats:styled-content style=\"fixed-case\">GFR<\/jats:styled-content>) was estimated by creatinine\u2010based and cystatin <jats:styled-content style=\"fixed-case\">C<\/jats:styled-content>\u2010based equations. Highest <jats:styled-content style=\"fixed-case\">NGAL<\/jats:styled-content> levels were among patients on pre\u2010<jats:styled-content style=\"fixed-case\">LT<\/jats:styled-content> kidney\u2010replacement therapy, whereas <jats:styled-content style=\"fixed-case\">NGAL<\/jats:styled-content> exceeded 200\u00a0\u03bcg\/L in only three (2%) patients with pre\u2010<jats:styled-content style=\"fixed-case\">LT GFR<\/jats:styled-content> &gt;60\u00a0mL\/min. Pre\u2010<jats:styled-content style=\"fixed-case\">LT NGAL<\/jats:styled-content> &gt;260\u00a0\u03bcg\/L predicted <jats:styled-content style=\"fixed-case\">GFR<\/jats:styled-content> &lt;60\u00a0mL\/min at three\u00a0months post\u2010<jats:styled-content style=\"fixed-case\">LT<\/jats:styled-content> (<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content> 17.8, 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> 2.1\u2013153) independently of 19 other variables reflecting recipient characteristics, liver and kidney function, perioperative hemodynamic stress, and immunosuppression. Of 81 patients with pre\u2010<jats:styled-content style=\"fixed-case\">LT GFR<\/jats:styled-content> &lt;60\u00a0mL\/min, 48% had <jats:styled-content style=\"fixed-case\">GFR<\/jats:styled-content> &lt;60\u00a0mL\/min at three\u00a0months, and an <jats:styled-content style=\"fixed-case\">NGAL<\/jats:styled-content> level &gt;260\u00a0\u03bcg\/L predicted this outcome with 90% specificity and 46% sensitivity. <jats:styled-content style=\"fixed-case\">NGAL<\/jats:styled-content> failed to predict post\u2010<jats:styled-content style=\"fixed-case\">LT AKI<\/jats:styled-content> or need for temporary kidney\u2010replacement therapy. In conclusion, <jats:styled-content style=\"fixed-case\">NGAL<\/jats:styled-content> independently predicted irreversibility of pre\u2010LT kidney dysfunction and could thus help in optimizing patient care and in the decision to perform combined liver\u2013kidney transplantation. Pre\u2010<jats:styled-content style=\"fixed-case\">LT NGAL<\/jats:styled-content> was not useful in patients with preserved pre\u2010<jats:styled-content style=\"fixed-case\">LT<\/jats:styled-content> kidney function or in predicting post\u2010<jats:styled-content style=\"fixed-case\">LT AKI<\/jats:styled-content>.<\/jats:p>","DOI":"10.1111\/ctr.12394","type":"journal-article","created":{"date-parts":[[2014,6,13]],"date-time":"2014-06-13T11:52:24Z","timestamp":1402660344000},"page":"869-876","source":"Crossref","is-referenced-by-count":18,"title":["Neutrophil gelatinase\u2010associated lipocalin associated with irreversibility of pre\u2010liver transplant kidney dysfunction"],"prefix":"10.1111","volume":"28","author":[{"given":"Fredrik","family":"\u00c5berg","sequence":"first","affiliation":[{"name":"Transplantation and Liver Surgery Clinic Helsinki University Hospital Helsinki Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marko","family":"Lempinen","sequence":"additional","affiliation":[{"name":"Transplantation and Liver Surgery Clinic Helsinki University Hospital Helsinki Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria","family":"Hollm\u00e9n","sequence":"additional","affiliation":[{"name":"Division of Nephrology Department of Medicine Helsinki University Hospital Helsinki Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Arno","family":"Nordin","sequence":"additional","affiliation":[{"name":"Transplantation and Liver Surgery Clinic Helsinki University Hospital Helsinki Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Heikki","family":"M\u00e4kisalo","sequence":"additional","affiliation":[{"name":"Transplantation and Liver Surgery Clinic Helsinki University Hospital Helsinki 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