{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T12:21:11Z","timestamp":1788870071940,"version":"build-2803163510"},"reference-count":37,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2014,9,11]],"date-time":"2014-09-11T00:00:00Z","timestamp":1410393600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Fondo Investigaci\u00ef\u00bf\u00bdn Sanitaria (FIS)","award":["PI10\/02496"],"award-info":[{"award-number":["PI10\/02496"]}]},{"name":"Fondo Investigaci\u00ef\u00bf\u00bdn Sanitaria (FIS)","award":["PIE13\/00027"],"award-info":[{"award-number":["PIE13\/00027"]}]},{"name":"Fondo Investigaci\u00ef\u00bf\u00bdn Sanitaria (FIS)","award":["I11\/0246"],"award-info":[{"award-number":["I11\/0246"]}]},{"name":"REDinREN","award":["RD\/0021\/0013"],"award-info":[{"award-number":["RD\/0021\/0013"]}]},{"name":"Sociedad Espa\u00ef\u00bf\u00bdola de Trasplantes (SET)"},{"name":"Vall Hebron Research Institute (VHIR)"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Transplantation"],"published-print":{"date-parts":[[2014,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>\n                      Transplant glomerulopathy (\n                      <jats:styled-content style=\"fixed-case\">TG<\/jats:styled-content>\n                      ) is the characteristic lesion of chronic antibody\u2010mediated rejection (\n                      <jats:styled-content style=\"fixed-case\">AMR<\/jats:styled-content>\n                      ). However, in some patients presents with no circulating\n                      <jats:styled-content style=\"fixed-case\">HLA<\/jats:styled-content>\n                      antibodies or C4d positivity.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>\n                      Patients with\n                      <jats:styled-content style=\"fixed-case\">TG<\/jats:styled-content>\n                      accomplishing criteria for chronic\n                      <jats:styled-content style=\"fixed-case\">AMR<\/jats:styled-content>\n                      were compared to patients with isolated\n                      <jats:styled-content style=\"fixed-case\">TG<\/jats:styled-content>\n                      .\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Patients and Methods<\/jats:title>\n                    <jats:p>\n                      We reviewed late (&gt;6\u00a0months) graft biopsies performed between 2007 and 2010 (n\u00a0=\u00a075). Biopsies with C4d\u2010negative\n                      <jats:styled-content style=\"fixed-case\">TG<\/jats:styled-content>\n                      and no circulating donor\u2010specific antibody were called isolated\n                      <jats:styled-content style=\"fixed-case\">TG<\/jats:styled-content>\n                      (n\u00a0=\u00a012), and chronic\n                      <jats:styled-content style=\"fixed-case\">AMR<\/jats:styled-content>\n                      was defined according to Banff consensus (n\u00a0=\u00a017).\n                      <jats:styled-content style=\"fixed-case\">HLA<\/jats:styled-content>\n                      antibodies were evaluated by Luminex technology. Immunohistochemistry was performed to quantify graft infiltrating cells.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Patients with isolated\n                      <jats:styled-content style=\"fixed-case\">TG<\/jats:styled-content>\n                      were older (52\u00a0\u00b1\u00a014 vs. 35\u00a0\u00b1\u00a014; p\u00a0=\u00a00.0048), received grafts from older donors (54\u00a0\u00b1\u00a016 vs. 41\u00a0\u00b1\u00a018; p\u00a0=\u00a00.0554), and displayed a lower inflammation in the glomerular (g\u2010score: 0.5\u00a0\u00b1\u00a00.5 vs. 1.0\u00a0\u00b1\u00a00.9; p\u00a0=\u00a00.0865;\n                      <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>\n                      3 positive cells\/glomeruli: 1.5\u00a0\u00b1\u00a02.9 vs. 4.4\u00a0\u00b1\u00a04.1; p\u00a0=\u00a00.0147), interstitial (i\u2010score: 1.2\u00a0\u00b1\u00a00.9 vs. 1.9\u00a0\u00b1\u00a01.0; p\u00a0=\u00a00.0685;\n                      <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>\n                      45 positive cells\/hpf: 18\u00a0\u00b1\u00a011 vs. 57\u00a0\u00b1\u00a068; p\u00a0=\u00a00.0132), and peritubular capillary (ptc\u2010score 0.2\u00a0\u00b1\u00a00.6 vs. 1.1\u00a0\u00b1\u00a00.9; p\u00a0=\u00a00.0089;\n                      <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>\n                      45 positive cells\/hpf: 3.7\u00a0\u00b1\u00a03.1 vs. 10.1\u00a0\u00b1\u00a07.4; p\u00a0=\u00a00.0290) compartments. Fifteen grafts were lost and graft survival was significantly lower in patients with chronic\n                      <jats:styled-content style=\"fixed-case\">AMR<\/jats:styled-content>\n                      (p\u00a0=\u00a00.0122).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>\n                      Isolated\n                      <jats:styled-content style=\"fixed-case\">TG<\/jats:styled-content>\n                      is associated with less severe allograft inflammation and with a better outcome than chronic\n                      <jats:styled-content style=\"fixed-case\">AMR<\/jats:styled-content>\n                      .\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/ctr.12433","type":"journal-article","created":{"date-parts":[[2014,8,8]],"date-time":"2014-08-08T07:51:44Z","timestamp":1407484304000},"page":"1148-1154","source":"Crossref","is-referenced-by-count":17,"title":["Comparing transplant glomerulopathy in the absence of C4d deposition and donor\u2010specific antibodies to chronic antibody\u2010mediated rejection"],"prefix":"10.1111","volume":"28","author":[{"given":"Irina B.","family":"Torres","sequence":"first","affiliation":[{"name":"Department of Nephrology Hospital Universitari Vall d'Hebron Universitat Aut\u00f2noma Barcelona Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maite","family":"Salcedo","sequence":"additional","affiliation":[{"name":"Department of Pathology Hospital Universitari Vall d'Hebron Universitat Aut\u00f2noma Barcelona Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesc","family":"Moreso","sequence":"additional","affiliation":[{"name":"Department of Nephrology Hospital Universitari Vall d'Hebron Universitat Aut\u00f2noma Barcelona Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joana","family":"Sellar\u00e9s","sequence":"additional","affiliation":[{"name":"Department of Nephrology Hospital Universitari Vall d'Hebron Universitat Aut\u00f2noma Barcelona Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eva","family":"Castell\u00e1","sequence":"additional","affiliation":[{"name":"Department of Radiology Hospital Universitari Vall d'Hebron Universitat Aut\u00f2noma Barcelona Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. 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