{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T14:08:12Z","timestamp":1785420492129,"version":"3.56.0"},"reference-count":29,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2014,9,11]],"date-time":"2014-09-11T00:00:00Z","timestamp":1410393600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Transplantation"],"published-print":{"date-parts":[[2014,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Tacrolimus is a <jats:styled-content style=\"fixed-case\">CYP<\/jats:styled-content>3A4 inhibitor and can alter colchicine metabolism. In this study, we aimed to evaluate plasma colchicine levels in different stages of kidney disease as well as in kidney transplant (<jats:styled-content style=\"fixed-case\">KT<\/jats:styled-content>x) recipients using tacrolimus.<\/jats:p><\/jats:sec><jats:sec><jats:title>Method<\/jats:title><jats:p>This study included six familial Mediterranean fever (<jats:styled-content style=\"fixed-case\">FMF<\/jats:styled-content>) patients with normal glomerular filtration rate (<jats:styled-content style=\"fixed-case\">GFR<\/jats:styled-content>) as controls, three patients with low <jats:styled-content style=\"fixed-case\">GFR<\/jats:styled-content>, six <jats:styled-content style=\"fixed-case\">FMF<\/jats:styled-content> patients on hemodialysis (<jats:styled-content style=\"fixed-case\">HD<\/jats:styled-content>), and six <jats:styled-content style=\"fixed-case\">FMF<\/jats:styled-content> patients who were <jats:styled-content style=\"fixed-case\">KT<\/jats:styled-content>x recipients using tacrolimus. After a three\u2010d washout period, plasma colchicine levels were measured at 0 (pre\u2010dose), one, two, four, eight, and 24\u00a0h post\u2010dose of 1\u00a0mg oral colchicine. Area under the curve 0\u201324\u00a0h (<jats:styled-content style=\"fixed-case\">AUC<\/jats:styled-content><jats:sub>0\u201324<\/jats:sub>) and maximum concentration (<jats:italic>C<\/jats:italic><jats:sub>max<\/jats:sub>) were evaluated and compared between the groups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Colchicine <jats:styled-content style=\"fixed-case\">AUC<\/jats:styled-content><jats:sub>0\u201324<\/jats:sub> was six\u2010fold higher in <jats:styled-content style=\"fixed-case\">HD<\/jats:styled-content> (p\u00a0&lt;\u00a00.001) and three\u2010fold higher in <jats:styled-content style=\"fixed-case\">KT<\/jats:styled-content>x recipients (p\u00a0&lt;\u00a00.001) when compared to the control. The low <jats:styled-content style=\"fixed-case\">GFR<\/jats:styled-content> group had mildly higher <jats:styled-content style=\"fixed-case\">AUC<\/jats:styled-content><jats:sub>0\u201324<\/jats:sub> than the control group. <jats:italic>C<\/jats:italic><jats:sub>max<\/jats:sub> levels were also higher in <jats:styled-content style=\"fixed-case\">HD<\/jats:styled-content> (p\u00a0=\u00a00.011) and <jats:styled-content style=\"fixed-case\">KT<\/jats:styled-content>x recipient (p\u00a0=\u00a00.06) groups and mildly elevated in low <jats:styled-content style=\"fixed-case\">GFR<\/jats:styled-content> patients in comparison with controls.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Colchicine <jats:styled-content style=\"fixed-case\">AUC<\/jats:styled-content><jats:sub>0\u201324<\/jats:sub> and <jats:italic>C<\/jats:italic><jats:sub>max<\/jats:sub> were significantly increased in <jats:styled-content style=\"fixed-case\">HD<\/jats:styled-content> patients and <jats:styled-content style=\"fixed-case\">KT<\/jats:styled-content>x recipients using tacrolimus. Therefore, dose adjustments are needed to avoid toxicity in both circumstances.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ctr.12448","type":"journal-article","created":{"date-parts":[[2014,8,14]],"date-time":"2014-08-14T14:46:53Z","timestamp":1408027613000},"page":"1177-1183","source":"Crossref","is-referenced-by-count":19,"title":["Colchicine levels in chronic kidney diseases and kidney transplant recipients using tacrolimus"],"prefix":"10.1111","volume":"28","author":[{"given":"Anara","family":"Amanova","sequence":"first","affiliation":[{"name":"Department of Internal Medicine Ankara University School of Medicine Ankara Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zeynep","family":"Kendi Celebi","sequence":"additional","affiliation":[{"name":"Department of Nephrology Ankara University School of Medicine Ankara Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Filiz","family":"Bakar","sequence":"additional","affiliation":[{"name":"Department of Biochemistry Ankara University School of Pharmacy Ankara Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mehmet G.","family":"Caglayan","sequence":"additional","affiliation":[{"name":"Department of Analytical Chemistry Ankara University School of Pharmacy Ankara Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenan","family":"Keven","sequence":"additional","affiliation":[{"name":"Department of Nephrology Ankara University School of Medicine Ankara Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2014,9,11]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcb.24231"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0049-0172(98)80028-0"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2006-1434"},{"key":"e_1_2_6_5_1","first-page":"1302","article-title":"Colchicine for familial Mediterranean fever","volume":"287","author":"Goldfinger SE","year":"1972","journal-title":"J Med"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.2174\/1568010053622984"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12325-012-0028-6"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejim.2010.09.010"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.2009.04674.x"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-2952(96)00693-4"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1080\/15563650701779703"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.3810\/pgm.2012.07.2579"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1124\/dmd.111.043018"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-130-6-199903160-00002"},{"key":"e_1_2_6_15_1","unstructured":"ICH Harmonized Tripartite Guideline International Conference on Harmonization of Technical Requirements for Registration of Pharmaceuticals for Human Use Validation of Analytical Procedure: Text and Methodology Q2 (R1) International Conference on Harmonization Geneva Switzerland 1996."},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/0049-0172(91)90019-V"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.ndt.a027096"},{"key":"e_1_2_6_18_1","first-page":"710","article-title":"Colchicine disposition in patients with familial Mediterranean fever with renal impairment","volume":"21","author":"Ben\u2010Chetrit E","year":"1994","journal-title":"J Rheumatol"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00194404"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jbspin.2006.03.006"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1093\/jat\/21.1.70"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1097\/RHU.0b013e31828639e0"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10067-007-0696-9"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1097\/RHU.0b013e3181bbbcd7"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jemermed.2004.12.012"},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0736-4679(02)00430-4"},{"key":"e_1_2_6_27_1","doi-asserted-by":"publisher","DOI":"10.1093\/ckj\/sft129"},{"key":"e_1_2_6_28_1","unstructured":"S\u00fcleymanlarG AltiparmakMR SeyahiN TrabulusS.Turkish Society of Nephrology Registry of the Nephrology Dialysis and Transplantation in Turkey 2011."},{"key":"e_1_2_6_29_1","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/17.11.2003"},{"key":"e_1_2_6_30_1","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gfh890"}],"container-title":["Clinical Transplantation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fctr.12448","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ctr.12448","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,2]],"date-time":"2023-10-02T11:28:10Z","timestamp":1696246090000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/ctr.12448"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,9,11]]},"references-count":29,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2014,10]]}},"alternative-id":["10.1111\/ctr.12448"],"URL":"https:\/\/doi.org\/10.1111\/ctr.12448","archive":["Portico"],"relation":{},"ISSN":["0902-0063","1399-0012"],"issn-type":[{"value":"0902-0063","type":"print"},{"value":"1399-0012","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,9,11]]}}}