{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,7]],"date-time":"2026-11-07T03:57:09Z","timestamp":1794023829546,"version":"4.8.0"},"reference-count":27,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2014,11,4]],"date-time":"2014-11-04T00:00:00Z","timestamp":1415059200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Transplantation"],"published-print":{"date-parts":[[2014,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>This study reports on a large series of 200 dual kidney transplantations (DKTs) from expanded criteria donors (ECDs) and proposes specific ways to optimize outcomes. Data concerning 200 DKTs performed in the last 14\u00a0yr were retrospectively analyzed. Kidneys from high\u2010risk ECD were allocated for use in DKTs on an old\u2010for\u2010old basis after histological assessment. Different surgical techniques and immunosuppressant regimens were used over time, and the outcomes are discussed. Donors and recipients were a median 73 (70\u201377) and a 62 (58\u201367) yr old, respectively. Delayed graft function occurred in 31.5% of cases, and acute rejection in 13.5%. Patient and graft survival at five yr were 90.4% and 85.8%, respectively. Unilateral kidney placement was preferred for 75% of patients, and was associated with a low rate of surgical complications. Our current standard therapy comprising low\u2010dose calcineurin inhibitors (CNIs) associated with mammalian target of rapamycin inhibitors (<jats:styled-content style=\"fixed-case\">mTOR<\/jats:styled-content>) and steroids appears to offer the best risk\/benefit profile for elderly patients undergoing DKT. In our experience, outcomes after DKT can be improved by: (i) kidney clinical\u2013histological assessment; (ii) unilateral kidney placement; (iii) minimal use of CNI associated with <jats:styled-content style=\"fixed-case\">mTOR<\/jats:styled-content>.<\/jats:p>","DOI":"10.1111\/ctr.12475","type":"journal-article","created":{"date-parts":[[2014,10,9]],"date-time":"2014-10-09T05:09:26Z","timestamp":1412831366000},"page":"1433-1440","source":"Crossref","is-referenced-by-count":44,"title":["A single\u2010center experience with 200 dual kidney transplantations"],"prefix":"10.1111","volume":"28","author":[{"given":"Paolo","family":"Rigotti","sequence":"first","affiliation":[{"name":"Kidney and Pancreas Transplantation Unit Department of Surgical, Oncological and Gastroenterological Sciences Padua University Hospital University of Padua Padua Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giovanni","family":"Capovilla","sequence":"additional","affiliation":[{"name":"Kidney and Pancreas Transplantation Unit Department of Surgical, Oncological and Gastroenterological Sciences Padua University Hospital University of Padua Padua Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caterina","family":"Di Bella","sequence":"additional","affiliation":[{"name":"Kidney and Pancreas Transplantation Unit Department of Surgical, Oncological and Gastroenterological Sciences Padua University Hospital University of Padua Padua Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cristina","family":"Silvestre","sequence":"additional","affiliation":[{"name":"Kidney and Pancreas Transplantation Unit Department of Surgical, Oncological and Gastroenterological Sciences Padua University Hospital University of Padua Padua Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paola","family":"Donato","sequence":"additional","affiliation":[{"name":"Kidney and Pancreas Transplantation Unit Department of Surgical, Oncological and Gastroenterological Sciences Padua University Hospital University of Padua Padua Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicola","family":"Baldan","sequence":"additional","affiliation":[{"name":"Kidney and Pancreas Transplantation Unit Department of Surgical, Oncological and Gastroenterological Sciences Padua University Hospital University of Padua Padua Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lucrezia","family":"Furian","sequence":"additional","affiliation":[{"name":"Kidney and Pancreas Transplantation Unit Department of Surgical, Oncological and Gastroenterological Sciences Padua University Hospital University of Padua Padua Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2014,11,4]]},"reference":[{"key":"e_1_2_8_2_1","unstructured":"Report NITp [database online]. 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