{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,23]],"date-time":"2026-06-23T12:27:28Z","timestamp":1782217648780,"version":"3.54.5"},"reference-count":24,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2014,12,7]],"date-time":"2014-12-07T00:00:00Z","timestamp":1417910400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Transplantation"],"published-print":{"date-parts":[[2015,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Data regarding multiple myeloma (<jats:styled-content style=\"fixed-case\">MM<\/jats:styled-content>) that develops after kidney transplantation (<jats:styled-content style=\"fixed-case\">KT<\/jats:styled-content>x) are scarce. The outcomes of these patients were evaluated in a retrospective study.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Patients with newly diagnosed <jats:styled-content style=\"fixed-case\">MM<\/jats:styled-content> after <jats:styled-content style=\"fixed-case\">KT<\/jats:styled-content>x were selected. Patients with a diagnosis of <jats:styled-content style=\"fixed-case\">MM<\/jats:styled-content> or those who received treatment for monoclonal gammopathy of renal significance (<jats:styled-content style=\"fixed-case\">MGRS<\/jats:styled-content>) prior to <jats:styled-content style=\"fixed-case\">KT<\/jats:styled-content>x were excluded.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Between 2001 and 2012, seven patients developed <jats:styled-content style=\"fixed-case\">MM<\/jats:styled-content> after <jats:styled-content style=\"fixed-case\">KT<\/jats:styled-content>x. Reasons for <jats:styled-content style=\"fixed-case\">ESRD<\/jats:styled-content> included <jats:styled-content style=\"fixed-case\">ADPKD<\/jats:styled-content> (1), C1q nephropathy (1), <jats:styled-content style=\"fixed-case\">MPGN<\/jats:styled-content> (2), hypertensive nephrosclerosis (2), and chronic interstitial nephritis (1). Before <jats:styled-content style=\"fixed-case\">KT<\/jats:styled-content>x, only four patients had monoclonal protein studies, four had monoclonal gammopathy of undermined significance (<jats:styled-content style=\"fixed-case\">MGUS<\/jats:styled-content>), and two of them had clonal plasma cells in bone marrow. Median follow\u2010up after <jats:styled-content style=\"fixed-case\">MM<\/jats:styled-content> was 70\u00a0months (range 19\u2013100). Median survival was 80\u00a0months. Median time from <jats:styled-content style=\"fixed-case\">KT<\/jats:styled-content>x to <jats:styled-content style=\"fixed-case\">MM<\/jats:styled-content> was 72\u00a0months (range 3\u2013204\u00a0months). The Kidney allograft failed in four patients due to monoclonal protein\u2010related renal disease. Five patients received chemotherapy: bortezomib (n\u00a0=\u00a03), lenalidomide (n\u00a0=\u00a02), melphalan (n\u00a0=\u00a01), thalidomide (n\u00a0=\u00a01), pomalidomide (n\u00a0=\u00a01), and high\u2010dose dexamethasone (n\u00a0=\u00a01). Three patients received <jats:styled-content style=\"fixed-case\">ASCT<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Multiple myeloma after <jats:styled-content style=\"fixed-case\">KT<\/jats:styled-content>x is rare. Most patients who develop <jats:styled-content style=\"fixed-case\">MM<\/jats:styled-content> had <jats:styled-content style=\"fixed-case\">MGUS<\/jats:styled-content> prior to <jats:styled-content style=\"fixed-case\">KT<\/jats:styled-content>x. There is significant renal involvement in these patients. Survival is not worse when compared to <jats:styled-content style=\"fixed-case\">MM<\/jats:styled-content> without <jats:styled-content style=\"fixed-case\">KT<\/jats:styled-content>x. Further work is needed to identify the best treatment options for these patients.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ctr.12482","type":"journal-article","created":{"date-parts":[[2014,11,6]],"date-time":"2014-11-06T07:38:30Z","timestamp":1415259510000},"page":"76-84","source":"Crossref","is-referenced-by-count":18,"title":["Multiple myeloma after kidney transplantation"],"prefix":"10.1111","volume":"29","author":[{"given":"Sami","family":"Safadi","sequence":"first","affiliation":[{"name":"Division of Nephrology and Hypertension Department of Medicine Mayo Clinic Rochester MN USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angela","family":"Dispenzieri","sequence":"additional","affiliation":[{"name":"Division of Hematology Department of Medicine Mayo Clinic Rochester MN USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hatem","family":"Amer","sequence":"additional","affiliation":[{"name":"Division of Nephrology and Hypertension Department of Medicine Mayo Clinic Rochester MN USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Morie A.","family":"Gertz","sequence":"additional","affiliation":[{"name":"Division of Hematology Department of Medicine Mayo Clinic Rochester MN USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S. 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