{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T05:29:18Z","timestamp":1791178158119,"version":"4.1.0"},"reference-count":26,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2015,1,8]],"date-time":"2015-01-08T00:00:00Z","timestamp":1420675200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Transplantation"],"published-print":{"date-parts":[[2015,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Autoantibodies are frequently detected after liver transplantation (<jats:styled-content style=\"fixed-case\">LT<\/jats:styled-content>), but their role is unclear. This study was designed to address three points: autoantibody prevalence pre\u2010<jats:styled-content style=\"fixed-case\">LT<\/jats:styled-content> and over time up to five yr after <jats:styled-content style=\"fixed-case\">LT<\/jats:styled-content>, identification of possible predictors of autoantibody formation, and correlation between autoantibodies and graft dysfunction. To these aims, we retrospectively evaluated 92 consecutive <jats:styled-content style=\"fixed-case\">LT<\/jats:styled-content> recipients for whom prospectively stored frozen sera were available for autoantibodies assessment by immunofluorescence. The overall autoantibody prevalence resulted significantly higher after <jats:styled-content style=\"fixed-case\">LT<\/jats:styled-content> than before <jats:styled-content style=\"fixed-case\">LT<\/jats:styled-content> (64% vs. 27%, p<jats:italic>\u00a0<\/jats:italic>&lt;<jats:italic>\u00a0<\/jats:italic>0.001 and 35.9% vs. 8.7%, p<jats:italic>\u00a0<\/jats:italic>&lt;<jats:italic>\u00a0<\/jats:italic>0.001 considering cutoff titer of \u22651:80 and \u22651:160, respectively). Recipient gender, donor age and gender, and indication for <jats:styled-content style=\"fixed-case\">LT<\/jats:styled-content> and main immunosuppressant (cyclosporine vs. tacrolimus) were not associated with the presence of autoantibodies. Patients with graft dysfunction had a significantly higher autoantibody prevalence irrespective of the etiology of liver injury as compared to those patients with persistently normal liver biochemistry, but only for cutoff titers \u22651:160 (p<jats:italic>\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>0.004). No cases of <jats:italic>de novo<\/jats:italic> autoimmune hepatitis were observed. In conclusion, autoantibodies are very frequently detected after <jats:styled-content style=\"fixed-case\">LT<\/jats:styled-content> also at high titers and their association with graft dysfunction likely represents an aspecific indicator of liver injury.<\/jats:p>","DOI":"10.1111\/ctr.12498","type":"journal-article","created":{"date-parts":[[2014,12,19]],"date-time":"2014-12-19T11:21:50Z","timestamp":1418988110000},"page":"161-166","source":"Crossref","is-referenced-by-count":14,"title":["Autoimmunity after liver transplantation: a frequent event but a rare clinical problem"],"prefix":"10.1111","volume":"29","author":[{"given":"Antonella","family":"Foschi","sequence":"first","affiliation":[{"name":"Struttura Complessa di Gastroenterologia ed Epatologia Ospedale Niguarda Ca' Granda Milano Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudio Antonio","family":"Zavaglia","sequence":"additional","affiliation":[{"name":"Struttura Complessa di Gastroenterologia ed Epatologia Ospedale Niguarda Ca' Granda Milano Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diana","family":"Fanti","sequence":"additional","affiliation":[{"name":"Struttura Complessa di Analisi Chimico\u2010Cliniche e Microbiologia Ospedale Niguarda Ca' Granda Milano Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chiara","family":"Mazzarelli","sequence":"additional","affiliation":[{"name":"Struttura Complessa di Gastroenterologia ed Epatologia Ospedale Niguarda Ca' Granda Milano Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giovanni","family":"Perricone","sequence":"additional","affiliation":[{"name":"Struttura Complessa di Gastroenterologia ed Epatologia Ospedale Niguarda Ca' Granda Milano Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcello","family":"Vangeli","sequence":"additional","affiliation":[{"name":"Struttura Complessa di Gastroenterologia ed Epatologia Ospedale Niguarda Ca' Granda Milano Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raffaella","family":"Vigan\u00f2","sequence":"additional","affiliation":[{"name":"Struttura Complessa di Gastroenterologia ed Epatologia Ospedale Niguarda Ca' Granda Milano Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luca Saverio","family":"Belli","sequence":"additional","affiliation":[{"name":"Struttura Complessa di Gastroenterologia ed Epatologia Ospedale Niguarda Ca' Granda Milano 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