{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T07:51:57Z","timestamp":1740124317298,"version":"3.37.3"},"reference-count":32,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2015,2,18]],"date-time":"2015-02-18T00:00:00Z","timestamp":1424217600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100004329","name":"Genzyme","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004329","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Transplantation"],"published-print":{"date-parts":[[2015,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>B cells and their regulation by B\u2010cell activating factor <jats:styled-content style=\"fixed-case\">BAFF<\/jats:styled-content> are of growing interest in kidney transplantation (<jats:styled-content style=\"fixed-case\">KT<\/jats:styled-content>x). There is evidence that high serum (s) <jats:styled-content style=\"fixed-case\">BAFF<\/jats:styled-content> leads to increased allosensitization and impaired long\u2010term graft function. We prospectively investigated <jats:styled-content style=\"fixed-case\">sBAFF<\/jats:styled-content>, peripheral blood lymphocytes (<jats:styled-content style=\"fixed-case\">PBL<\/jats:styled-content>), and donor\u2010specific <jats:styled-content style=\"fixed-case\">HLA<\/jats:styled-content> antibodies (<jats:styled-content style=\"fixed-case\">DSA<\/jats:styled-content>) in patients after <jats:styled-content style=\"fixed-case\">ABO<\/jats:styled-content>i with B\u2010cell depleting rituximab induction treatment and compared them to a group of blood group\u2010compatible (<jats:styled-content style=\"fixed-case\">ABO<\/jats:styled-content>c) living donor kidney recipients. Twelve patients after <jats:styled-content style=\"fixed-case\">ABO<\/jats:styled-content>i and 18 after <jats:styled-content style=\"fixed-case\">ABO<\/jats:styled-content>c were included. After rituximab treatment prior to <jats:styled-content style=\"fixed-case\">ABO<\/jats:styled-content>i, B cells remained significantly lower 1\u00a0year after <jats:styled-content style=\"fixed-case\">KT<\/jats:styled-content>x (1.2% (0.0\u201317.8) compared to <jats:styled-content style=\"fixed-case\">ABO<\/jats:styled-content>c of 8.6% (2.8\u201335.0), p<jats:italic>\u00a0=\u00a00.0004<\/jats:italic>, and also <jats:styled-content style=\"fixed-case\">BAFF<\/jats:styled-content>\u2010R expression was significantly lower in <jats:styled-content style=\"fixed-case\">ABO<\/jats:styled-content>i <jats:italic>(p\u00a0&lt;\u00a00.006)<\/jats:italic>. <jats:styled-content style=\"fixed-case\">sBAFF<\/jats:styled-content> remained elevated 1\u00a0year post\u2010Tx compared to <jats:styled-content style=\"fixed-case\">ABO<\/jats:styled-content>c (3615\u00a0\u00b1\u00a01800 vs. 1394\u00a0\u00b1\u00a0493\u00a0pg\/mL, <jats:italic>p\u00a0&lt;\u00a00.004)<\/jats:italic>. Kidney function was not significantly different between both groups after 1, 2, and 3\u00a0years. The use of rituximab in <jats:styled-content style=\"fixed-case\">ABO<\/jats:styled-content>i together with maintenance immunosuppression leads to significant elevation of <jats:styled-content style=\"fixed-case\">sBAFF<\/jats:styled-content> and lowering of B\u2010cell numbers for more than 1\u00a0year, and this does not correlate with worse 3\u2010year graft outcome.<\/jats:p>","DOI":"10.1111\/ctr.12523","type":"journal-article","created":{"date-parts":[[2015,1,27]],"date-time":"2015-01-27T10:33:13Z","timestamp":1422354793000},"page":"359-364","source":"Crossref","is-referenced-by-count":3,"title":["High B\u2010cell activating factor is not associated with worse 3\u2010year graft outcome in blood group\u2010incompatible kidney transplantation with rituximab induction"],"prefix":"10.1111","volume":"29","author":[{"given":"Anja M.","family":"Lehnhardt","sequence":"first","affiliation":[{"name":"Department of Hepatobiliary Surgery and Transplantation at University Medical Center Hamburg\u2010Eppendorf Hamburg Germany"},{"name":"Department of Pediatric Nephrology at University Medical Center Hamburg\u2010Eppendorf Hamburg Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maximiliane","family":"Strecker","sequence":"additional","affiliation":[{"name":"Department of Hepatobiliary Surgery and Transplantation at University Medical Center Hamburg\u2010Eppendorf Hamburg Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas","family":"Eiermann","sequence":"additional","affiliation":[{"name":"Department of Transfusion Medicine HLA\u2010Laboratory at University Medical Center Hamburg\u2010Eppendorf Hamburg Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matthias","family":"Marget","sequence":"additional","affiliation":[{"name":"Department of Transfusion Medicine HLA\u2010Laboratory at University Medical Center Hamburg\u2010Eppendorf Hamburg Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Friedrich","family":"Thaiss","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine\/Nephrology at University Medical Center Hamburg\u2010Eppendorf Hamburg Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bj\u00f6rn","family":"Nashan","sequence":"additional","affiliation":[{"name":"Department of Hepatobiliary Surgery and Transplantation at University Medical Center Hamburg\u2010Eppendorf Hamburg Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Martina","family":"Koch","sequence":"additional","affiliation":[{"name":"Department of Hepatobiliary Surgery and Transplantation at University Medical Center Hamburg\u2010Eppendorf Hamburg 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