{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,10,3]],"date-time":"2023-10-03T06:40:58Z","timestamp":1696315258720},"reference-count":23,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2015,4,22]],"date-time":"2015-04-22T00:00:00Z","timestamp":1429660800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Transplantation"],"published-print":{"date-parts":[[2015,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:styled-content style=\"fixed-case\">CCR<\/jats:styled-content>6 is a chemokine receptor involved in homing memory <jats:styled-content style=\"fixed-case\">T<\/jats:styled-content> cells, particularly <jats:styled-content style=\"fixed-case\">T<\/jats:styled-content>h17 cells, to sites of mucosal inflammation. Despite the critical role of memory <jats:styled-content style=\"fixed-case\">T<\/jats:styled-content> cells in long\u2010term protective immunity against cytomegalovirus (<jats:styled-content style=\"fixed-case\">CMV<\/jats:styled-content>), a virus that reactivates at multiple mucosal sites, the ability of <jats:styled-content style=\"fixed-case\">CCR<\/jats:styled-content>6 or other <jats:styled-content style=\"fixed-case\">T<\/jats:styled-content>h17 marker expression to predict <jats:styled-content style=\"fixed-case\">CMV<\/jats:styled-content> reactivation following transplantation is not clear. Using 11\u2010color flow cytometry, in this prospective single\u2010center pilot study, we measured the expression of <jats:styled-content style=\"fixed-case\">CCR<\/jats:styled-content>6 and other markers of <jats:styled-content style=\"fixed-case\">T<\/jats:styled-content>\u2010cell function in peripheral blood samples obtained from 21 <jats:styled-content style=\"fixed-case\">SOT<\/jats:styled-content> recipients at the time of discontinuation of anti\u2010<jats:styled-content style=\"fixed-case\">CMV<\/jats:styled-content> prophylaxis. <jats:styled-content style=\"fixed-case\">CMV<\/jats:styled-content> viremia was monitored on a monthly basis after discontinuation of prophylaxis. Eleven patients (52%) developed <jats:styled-content style=\"fixed-case\">CMV<\/jats:styled-content> viremia during the six\u2010month follow\u2010up period. Late\u2010onset <jats:styled-content style=\"fixed-case\">CMV<\/jats:styled-content> infection was preceded by an immune phenotype characterized by increased <jats:styled-content style=\"fixed-case\">CCR<\/jats:styled-content>6 expression on bulk <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>4<jats:sup>+<\/jats:sup> <jats:styled-content style=\"fixed-case\">T<\/jats:styled-content> cells and a reduced number of circulating <jats:styled-content style=\"fixed-case\">CMV IE<\/jats:styled-content>\u20101\u2010specific <jats:styled-content style=\"fixed-case\">T<\/jats:styled-content>h1 (<jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>4<jats:sup>+<\/jats:sup>\u00a0<jats:styled-content style=\"fixed-case\">IFN<\/jats:styled-content>\u2010\u03b3<jats:sup>+<\/jats:sup>) cells. Among the markers evaluated, <jats:styled-content style=\"fixed-case\">CCR<\/jats:styled-content>6 was the best single predictor of late\u2010onset <jats:styled-content style=\"fixed-case\">CMV<\/jats:styled-content> infection. Our results suggest that <jats:styled-content style=\"fixed-case\">CCR<\/jats:styled-content>6 expression at the time of discontinuation of antiviral prophylaxis might be a useful predictor of late\u2010onset <jats:styled-content style=\"fixed-case\">CMV<\/jats:styled-content> reactivation and provide the basis for future larger prospective studies.<\/jats:p>","DOI":"10.1111\/ctr.12531","type":"journal-article","created":{"date-parts":[[2015,2,17]],"date-time":"2015-02-17T05:39:57Z","timestamp":1424151597000},"page":"492-498","source":"Crossref","is-referenced-by-count":5,"title":["Potential role of <scp>CC<\/scp> chemokine receptor 6 in prediction of late\u2010onset cytomegalovirus infection following solid organ transplant"],"prefix":"10.1111","volume":"29","author":[{"given":"Jose F.","family":"Camargo","sequence":"first","affiliation":[{"name":"Transplant Infectious Diseases Multi\u2010Organ Transplant Program University Health Network University of Toronto Toronto ON 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