{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,11]],"date-time":"2025-11-11T13:09:42Z","timestamp":1762866582722},"reference-count":25,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2015,3,24]],"date-time":"2015-03-24T00:00:00Z","timestamp":1427155200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Transplantation"],"published-print":{"date-parts":[[2015,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Alemtuzumab and rabbit antithymocyte globulin (r<jats:styled-content style=\"fixed-case\">ATG<\/jats:styled-content>) are commonly used for induction therapy in renal transplantation. This retrospective, single\u2010center, cohort study evaluated cumulative incidence of one\u2010yr biopsy\u2010proven acute rejection (<jats:styled-content style=\"fixed-case\">BPAR<\/jats:styled-content>) among 200 consecutive primary non\u2010sensitized kidney transplant recipients who received either alemtuzumab (n\u00a0=\u00a0100) or r<jats:styled-content style=\"fixed-case\">ATG<\/jats:styled-content> (n\u00a0=\u00a0100) induction followed by rapid steroid taper, tacrolimus, and mycophenolate mofetil. Protocol biopsies, plasma and urine <jats:styled-content style=\"fixed-case\">BK<\/jats:styled-content> virus <jats:styled-content style=\"fixed-case\">PCR<\/jats:styled-content>, serum creatinine and iothalamate glomerular filtration rate (iGFR), were obtained at 1, 4, and 12\u00a0months from transplantation. The one\u2010yr BPAR rates were similar between the alemtuzumab and rATG groups; however, rejection Banff IA and higher was more common in the alemtuzumab arm (18% vs. 5%, p\u00a0=\u00a00.047). After adjusting for confounding variables, alemtuzumab was still associated with Banff IA and higher rejection (adjusted OR: 3.7, CI: 1.2\u201310.5, p\u00a0=\u00a00.02). Despite similar rates of BK viremia, more patients in the alemtuzumab arm developed <jats:styled-content style=\"fixed-case\">BK<\/jats:styled-content> nephropathy (16% vs. 3%, p\u00a0=\u00a00.046). One\u2010year iGFR (53.4\u00a0\u00b1\u00a020.2 vs. 71.9\u00a0\u00b1\u00a027.2\u00a0mL\/min\/1.73\u00a0m<jats:sup>2<\/jats:sup>, p<jats:italic>\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>0.002) and three\u2010yr graft survival (89.5% vs. 95%, p\u00a0=\u00a00.05) were lower in the alemtuzumab group. In low immunological risk kidney transplant recipients on steroid\u2010free immunosuppression, alemtuzumab was associated with more severe rejection and <jats:styled-content style=\"fixed-case\">BK<\/jats:styled-content> nephropathy compared to r<jats:styled-content style=\"fixed-case\">ATG<\/jats:styled-content>.<\/jats:p>","DOI":"10.1111\/ctr.12532","type":"journal-article","created":{"date-parts":[[2015,2,25]],"date-time":"2015-02-25T06:07:05Z","timestamp":1424844425000},"page":"573-580","source":"Crossref","is-referenced-by-count":14,"title":["Comparison of alemtuzumab vs. antithymocyte globulin induction therapy in primary non\u2010sensitized renal transplant patients treated with rapid steroid withdrawal"],"prefix":"10.1111","volume":"29","author":[{"given":"Harrison E.","family":"Saull","sequence":"first","affiliation":[{"name":"Department of Pharmacy Mayo Clinic Jacksonville FL USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cher 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