{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T09:07:30Z","timestamp":1791191250319,"version":"4.1.0"},"reference-count":29,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2015,3,30]],"date-time":"2015-03-30T00:00:00Z","timestamp":1427673600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Transplantation"],"published-print":{"date-parts":[[2015,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Outcome of patients with transplant glomerulopathy (<jats:styled-content style=\"fixed-case\">TG<\/jats:styled-content>) is poor. Using B\u2010cell targeting molecules represent a rational strategy to treat <jats:styled-content style=\"fixed-case\">TG<\/jats:styled-content> during chronic antibody\u2010mediated rejection. In this pilot study, 21 patients with this diagnosis received four doses of intravenous immunoglobulins and two doses of rituximab (<jats:styled-content style=\"fixed-case\">IVIG<\/jats:styled-content>\/<jats:styled-content style=\"fixed-case\">RTX<\/jats:styled-content> group). They were retrospectively compared with a untreated control group of 10 patients. At 24\u00a0months post\u2010biopsy, graft survival was similar and poor between the treated and the untreated group, 47% vs. 40%, respectively, p\u00a0=\u00a00.69. This absence of response of <jats:styled-content style=\"fixed-case\">IVIG<\/jats:styled-content>\/<jats:styled-content style=\"fixed-case\">RTX<\/jats:styled-content> treatment was observed, regardless the phenotype of <jats:styled-content style=\"fixed-case\">TG<\/jats:styled-content>. Baseline estimated glomerular filtration rate (<jats:styled-content style=\"fixed-case\">eGFR<\/jats:styled-content>) and decline in <jats:styled-content style=\"fixed-case\">eGFR<\/jats:styled-content> during the first six months after the treatment were risk factors associated with 24\u2010month graft survival. The <jats:styled-content style=\"fixed-case\">IVIG<\/jats:styled-content>\/<jats:styled-content style=\"fixed-case\">RTX<\/jats:styled-content> therapy had a modest effect on the kinetics of donor\u2010specific alloantibodies at M24, compared to the untreated group, not associated with an improvement in graft survival. The mean number of adverse events per patient was higher in the <jats:styled-content style=\"fixed-case\">IVIG<\/jats:styled-content>\/<jats:styled-content style=\"fixed-case\">RTX<\/jats:styled-content> group than in the control group (p\u00a0=\u00a00.03). Taken together, <jats:styled-content style=\"fixed-case\">IVIG<\/jats:styled-content>\/<jats:styled-content style=\"fixed-case\">RTX<\/jats:styled-content> treatment for severe <jats:styled-content style=\"fixed-case\">TG<\/jats:styled-content> during chronic antibody\u2010mediated rejection does not seem to change the natural history of <jats:styled-content style=\"fixed-case\">TG<\/jats:styled-content> and is associated with a high incidence of adverse events.<\/jats:p>","DOI":"10.1111\/ctr.12535","type":"journal-article","created":{"date-parts":[[2015,3,4]],"date-time":"2015-03-04T15:01:51Z","timestamp":1425481311000},"page":"439-446","source":"Crossref","is-referenced-by-count":32,"title":["Intravenous immunoglobulins and rituximab therapy for severe transplant glomerulopathy in chronic antibody\u2010mediated rejection: a pilot study"],"prefix":"10.1111","volume":"29","author":[{"given":"Thomas","family":"Bachelet","sequence":"first","affiliation":[{"name":"Unit\u00e9 de Transplantation Service de N\u00e9phrologie, Transplantation, Dialyse CHU de Bordeaux Bordeaux France"},{"name":"UMR 5164 CNRS Bordeaux France"},{"name":"Universit\u00e9 de Bordeaux Bordeaux France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Celine","family":"Nodimar","sequence":"additional","affiliation":[{"name":"Unit\u00e9 de Transplantation Service de N\u00e9phrologie, Transplantation, Dialyse CHU de Bordeaux Bordeaux France"},{"name":"Universit\u00e9 de Bordeaux Bordeaux France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean\u2010Luc","family":"Taupin","sequence":"additional","affiliation":[{"name":"UMR 5164 CNRS Bordeaux France"},{"name":"Universit\u00e9 de Bordeaux Bordeaux France"},{"name":"Laboratoire d'Immunologie et Immunog\u00e9n\u00e9tique CHU Bordeaux Bordeaux France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sebastien","family":"Lepreux","sequence":"additional","affiliation":[{"name":"UMR 5164 CNRS Bordeaux 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