{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,26]],"date-time":"2025-12-26T11:17:15Z","timestamp":1766747835796},"reference-count":37,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2015,5,4]],"date-time":"2015-05-04T00:00:00Z","timestamp":1430697600000},"content-version":"vor","delay-in-days":3,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Transplantation"],"published-print":{"date-parts":[[2015,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Post\u2010transplantation diabetes mellitus (<jats:styled-content style=\"fixed-case\">PTDM<\/jats:styled-content>) is a serious complication after kidney transplantation, but evidence regarding long\u2010term outcomes of treatment regimens remains scarce.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aim and Methods<\/jats:title><jats:p>The aim of this retrospective cohort analysis was to assess the long\u2010term efficiency and safety of antidiabetic treatments in kidney transplant recipients (<jats:styled-content style=\"fixed-case\">KTR<\/jats:styled-content>s), who were diagnosed with <jats:styled-content style=\"fixed-case\">PTDM<\/jats:styled-content> by an oral glucose tolerance test (<jats:styled-content style=\"fixed-case\">OGTT<\/jats:styled-content>).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of 561 <jats:styled-content style=\"fixed-case\">KTR<\/jats:styled-content>s that were screened for <jats:styled-content style=\"fixed-case\">PTDM<\/jats:styled-content> at our outpatient clinic, 71 (13%) had a diabetic <jats:styled-content style=\"fixed-case\">OGTT<\/jats:styled-content> and were included in this study. Mean follow\u2010up was 34.2\u00a0\u00b1\u00a016.1\u00a0months. Thirty\u2010six <jats:styled-content style=\"fixed-case\">PTDM<\/jats:styled-content> patients (51%) received antidiabetic treatment after diagnosis with either a dipeptidyl peptidase\u20104 (<jats:styled-content style=\"fixed-case\">DPP<\/jats:styled-content>\u20104) inhibitor, a sulfonylurea, pioglitazone, or insulin. These patients had significantly higher fasting glucose and two\u2010h plasma glucose (2<jats:styled-content style=\"fixed-case\">HPG<\/jats:styled-content>) values at baseline than those who remained without therapy. In contrast to lifestyle modification alone or sulfonylureas, <jats:styled-content style=\"fixed-case\">DPP<\/jats:styled-content>\u20104 inhibitors improved glycemic control significantly. Adverse events were generally mild and occurred at similar rates in all groups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>While sulfonylureas failed to improve glycemic control, <jats:styled-content style=\"fixed-case\">DPP<\/jats:styled-content>\u20104 inhibitors appeared effective and safe for the therapy of <jats:styled-content style=\"fixed-case\">PTDM<\/jats:styled-content> after kidney transplantation.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ctr.12541","type":"journal-article","created":{"date-parts":[[2015,3,17]],"date-time":"2015-03-17T06:12:42Z","timestamp":1426572762000},"page":"415-424","source":"Crossref","is-referenced-by-count":13,"title":["Post\u2010transplantation diabetes mellitus: evaluation of treatment strategies"],"prefix":"10.1111","volume":"29","author":[{"given":"M.","family":"Haidinger","sequence":"first","affiliation":[{"name":"Clinical Division of Nephrology and Dialysis Department of Internal Medicine III Medical University of 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