{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,14]],"date-time":"2026-07-14T14:37:21Z","timestamp":1784039841595,"version":"3.55.0"},"reference-count":33,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2015,7,4]],"date-time":"2015-07-04T00:00:00Z","timestamp":1435968000000},"content-version":"vor","delay-in-days":3,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Transplantation"],"published-print":{"date-parts":[[2015,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Post\u2010kidney transplant recurrence of focal segmental glomerulosclerosis (FSGS) is a major problem. <jats:styled-content style=\"fixed-case\">AT<\/jats:styled-content>1R is expressed on podocyte; its expression is elevated in the proteinuric state. Using an <jats:styled-content style=\"fixed-case\">ELISA<\/jats:styled-content>, we tested pre\u2010transplant sera of 28 patients with history of idiopathic <jats:styled-content style=\"fixed-case\">FSGS<\/jats:styled-content> for anti\u2010<jats:styled-content style=\"fixed-case\">AT<\/jats:styled-content>1R levels and serum soluble urokinase\u2010type plasminogen activator receptor (su<jats:styled-content style=\"fixed-case\">PAR<\/jats:styled-content>) as a biomarker for risk of recurrence of <jats:styled-content style=\"fixed-case\">FSGS<\/jats:styled-content>. Sera from 11 patients with polycystic kidney disease (<jats:styled-content style=\"fixed-case\">PKD<\/jats:styled-content>) were used as controls. Twelve patients had biopsy proven post\u2010transplant <jats:styled-content style=\"fixed-case\">FSGS<\/jats:styled-content> recurrence at 1.5\u00a0months. No difference was found in the pre\u2010transplant su<jats:styled-content style=\"fixed-case\">PAR<\/jats:styled-content> levels of <jats:styled-content style=\"fixed-case\">FSGS<\/jats:styled-content> patients (5993\u00a0\u00b1\u00a02292\u00a0pg\/mL) vs. <jats:styled-content style=\"fixed-case\">PKD<\/jats:styled-content> (7334\u00a0\u00b1\u00a04538\u00a0pg\/mL) (p\u00a0=\u00a00.23). Serum su<jats:styled-content style=\"fixed-case\">PAR<\/jats:styled-content> levels in patients with <jats:styled-content style=\"fixed-case\">FSGS<\/jats:styled-content> recurrence (5786\u00a0\u00b1\u00a01899\u00a0pg\/mL) vs. no <jats:styled-content style=\"fixed-case\">FSGS<\/jats:styled-content> recurrence (6149\u00a0\u00b1\u00a02598\u00a0pg\/mL) (p\u00a0=\u00a00.69) were not different. Anti\u2010<jats:styled-content style=\"fixed-case\">AT<\/jats:styled-content>1R levels in patients with <jats:styled-content style=\"fixed-case\">FSGS<\/jats:styled-content> were 12.66\u00a0\u00b1\u00a011.85\u00a0U\/mL vs. 8.69\u00a0\u00b1\u00a06.52\u00a0U\/mL in <jats:styled-content style=\"fixed-case\">PKD<\/jats:styled-content> (p\u00a0=\u00a00.32); however, a difference was found in patients with and without <jats:styled-content style=\"fixed-case\">FSGS<\/jats:styled-content> recurrence 20.41\u00a0\u00b1\u00a014.36\u00a0U\/mL 6.84\u00a0\u00b1\u00a04.181\u00a0U\/mL, respectively (p\u00a0&lt;\u00a00.01). Area under curve for su<jats:styled-content style=\"fixed-case\">PAR<\/jats:styled-content> and anti\u2010<jats:styled-content style=\"fixed-case\">AT<\/jats:styled-content>1R to predict post\u2010transplant <jats:styled-content style=\"fixed-case\">FSGS<\/jats:styled-content> recurrence was 0.51 and 0.84, respectively. Pre\u2010transplant anti\u2010<jats:styled-content style=\"fixed-case\">AT<\/jats:styled-content>1R levels appear to be a helpful biomarker in identifying patients at high risk of post\u2010transplant <jats:styled-content style=\"fixed-case\">FSGS<\/jats:styled-content> recurrence.<\/jats:p>","DOI":"10.1111\/ctr.12562","type":"journal-article","created":{"date-parts":[[2015,5,12]],"date-time":"2015-05-12T14:06:35Z","timestamp":1431439595000},"page":"606-611","source":"Crossref","is-referenced-by-count":24,"title":["Pre\u2010transplant angiotensin receptor <scp>II<\/scp> type 1 antibodies and risk of post\u2010transplant focal segmental glomerulosclerosis recurrence"],"prefix":"10.1111","volume":"29","author":[{"given":"Muhammad A.","family":"Mujtaba","sequence":"first","affiliation":[{"name":"Division of Nephrology University of Texas Medical Branch Galveston TX USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Asif A.","family":"Sharfuddin","sequence":"additional","affiliation":[{"name":"Division of Nephrology Indiana University School of Medicine Indianapolis IN USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benita L.","family":"Book","sequence":"additional","affiliation":[{"name":"Division of Transplant Surgery Indiana University School of Medicine Indianapolis IN USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William C.","family":"Goggins","sequence":"additional","affiliation":[{"name":"Division of Transplant Surgery Indiana University School of Medicine Indianapolis IN USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ali A.","family":"Khalil","sequence":"additional","affiliation":[{"name":"Division of Nephrology Indiana University School of Medicine Indianapolis IN USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dennis P.","family":"Mishler","sequence":"additional","affiliation":[{"name":"Division of Nephrology Indiana University School of Medicine Indianapolis IN USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johnathan A.","family":"Fridell","sequence":"additional","affiliation":[{"name":"Division of Transplant Surgery Indiana University School of Medicine Indianapolis IN USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Muhammad S.","family":"Yaqub","sequence":"additional","affiliation":[{"name":"Division of Nephrology Indiana University School of Medicine Indianapolis IN USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tim E.","family":"Taber","sequence":"additional","affiliation":[{"name":"Division of Nephrology Indiana University School of Medicine Indianapolis IN 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