{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,10]],"date-time":"2026-03-10T03:41:14Z","timestamp":1773114074601,"version":"3.50.1"},"reference-count":32,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2015,6,15]],"date-time":"2015-06-15T00:00:00Z","timestamp":1434326400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100005703","name":"Akdeniz \u00dcniversitesi","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100005703","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Transplantation"],"published-print":{"date-parts":[[2015,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Cytotoxic T\u2010lymphocyte antigen\u20104 (<jats:italic><jats:styled-content style=\"fixed-case\">CTLA<\/jats:styled-content>\u20104<\/jats:italic>) is a cell surface protein, which down\u2010regulates the immune response at <jats:styled-content style=\"fixed-case\">CTLA<\/jats:styled-content>\u20104\/<jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>28\/B7 pathway. We aimed to investigate the influence of the \u2212318C\/T, +49A\/G, \u22121661A\/G and <jats:styled-content style=\"fixed-case\">CT<\/jats:styled-content>60A\/G, and <jats:styled-content style=\"fixed-case\">CTLA<\/jats:styled-content>\u20104 gene polymorphisms on acute rejection of kidney allograft in Turkish patients. The study design was a case\u2013control study that consists of three groups: Group 1 (n\u00a0=\u00a034) represented the kidney transplant (<jats:italic>Ktx<\/jats:italic>) recipients who experienced acute rejection, Group 2 (n\u00a0=\u00a047) was randomly assigned Ktx recipients without acute rejection, and Group 3 (n\u00a0=\u00a050) consisting of healthy volunteers to evaluate the normal genomic distribution. The polymerase chain reaction\u2013restriction fragment length polymorphism technique was used to determine the polymorphisms. Genotype and allele frequencies among three groups denoted similar distributions for +49A\/G, \u22121661A\/G, and <jats:styled-content style=\"fixed-case\">CT<\/jats:styled-content>60A\/G. Conversely, \u2212318C\/T genotype was three times more frequent in the acute rejection group than in the non\u2010rejection group (<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content>\u00a0=\u00a03.45; 95%<jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>\u00a0=\u00a01.18\u201310.1, p<jats:italic>\u00a0=<\/jats:italic>\u00a00.015) and two times more frequent than the healthy control group (<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content>\u00a0=\u00a02.45; 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>\u00a0=\u00a00.98 \u2013 6.11, p\u00a0=\u00a00.047). Additionally, having a T allele at \u2212318 position was significantly associated with acute rejection (0.147 vs. 0.043, <jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content>\u00a0=\u00a03.45; 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>\u00a0=\u00a01.13\u201310.56, p\u00a0=\u00a00.02). 318C\/T gene polymorphism and T allelic variant were found to be associated with increased acute rejection risk in Turkish kidney allograft recipients.<\/jats:p>","DOI":"10.1111\/ctr.12563","type":"journal-article","created":{"date-parts":[[2015,5,15]],"date-time":"2015-05-15T15:13:52Z","timestamp":1431702832000},"page":"612-618","source":"Crossref","is-referenced-by-count":11,"title":["The influence of <scp>CTLA<\/scp>\u20104 single nucleotide polymorphisms on acute kidney allograft rejection in Turkish patients"],"prefix":"10.1111","volume":"29","author":[{"given":"\u00c7a\u011flar","family":"Ruhi","sequence":"first","affiliation":[{"name":"Transplantation Center and Health Sciences Research Center Akdeniz University Medical School Antalya Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nilg\u00fcn","family":"Sallak\u00e7i","sequence":"additional","affiliation":[{"name":"Transplantation Center and Health Sciences Research Center Akdeniz University Medical School Antalya Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Olcay","family":"Ye\u011fin","sequence":"additional","affiliation":[{"name":"Transplantation Center and Health Sciences Research Center Akdeniz University Medical School Antalya Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G\u00fcltekin","family":"S\u00fcleymanlar","sequence":"additional","affiliation":[{"name":"Transplantation Center and Health Sciences Research Center Akdeniz University Medical School Antalya Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F. Fevzi","family":"Ersoy","sequence":"additional","affiliation":[{"name":"Transplantation Center and Health Sciences Research Center Akdeniz University Medical School Antalya Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2015,6,15]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199806183382506"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/366076a0"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.7694361"},{"key":"e_1_2_6_5_1","first-page":"131","article-title":"The CD28\/CTLA\u20104\/B7 pathway in immunological regulation: the basis of disease and the promise of therapy","volume":"84","author":"Wong KM","year":"2007","journal-title":"UTMJ"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.183.6.2533"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1521-4141(199903)29:03<838::AID-IMMU838>3.0.CO;2-P"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.176.6.3321"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1521-4141(199911)29:11<3596::AID-IMMU3596>3.0.CO;2-Y"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-3083.2001.00985.x"},{"key":"e_1_2_6_11_1","first-page":"336","article-title":"The soluable CTLA\u20104 receptor: a new marker in autoimmune disease","volume":"53","author":"Pawlak E","year":"2005","journal-title":"Arch Immunol Ther Exp"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-0039.2006.00595.x"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00439-004-1244-1"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/41.2.180"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clim.2005.09.017"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.trim.2010.10.001"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.trim.2006.09.001"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-6143.2003.00084.x"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.transproceed.2005.11.094"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1600-6135.2003.00261.x"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.tp.0000184624.54005.9f"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.trim.2012.02.005"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.gene.6363869"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(90)90342-C"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2012.08.004"},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1746.2011.06662.x"},{"key":"e_1_2_6_27_1","doi-asserted-by":"publisher","DOI":"10.1093\/intimm\/dxp069"},{"key":"e_1_2_6_28_1","doi-asserted-by":"publisher","DOI":"10.3109\/00365511003695608"},{"key":"e_1_2_6_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clim.2007.01.003"},{"key":"e_1_2_6_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.trim.2007.07.003"},{"key":"e_1_2_6_31_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.165.11.6606"},{"key":"e_1_2_6_32_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2362.2004.01385.x"},{"key":"e_1_2_6_33_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11033-012-1727-4"}],"container-title":["Clinical Transplantation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fctr.12563","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ctr.12563","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,3]],"date-time":"2023-10-03T11:05:33Z","timestamp":1696331133000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/ctr.12563"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,6,15]]},"references-count":32,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2015,7]]}},"alternative-id":["10.1111\/ctr.12563"],"URL":"https:\/\/doi.org\/10.1111\/ctr.12563","archive":["Portico"],"relation":{},"ISSN":["0902-0063","1399-0012"],"issn-type":[{"value":"0902-0063","type":"print"},{"value":"1399-0012","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,6,15]]}}}