{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T19:52:46Z","timestamp":1791402766841,"version":"4.3.3"},"reference-count":31,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2015,7,14]],"date-time":"2015-07-14T00:00:00Z","timestamp":1436832000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Transplantation"],"published-print":{"date-parts":[[2015,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>We retrospectively analyzed outcome and risk factors of developing Charcot foot (<jats:styled-content style=\"fixed-case\">CF<\/jats:styled-content>) in 100 patients with type 1 diabetes mellitus who underwent a simultaneous pancreas\u2013kidney (<jats:styled-content style=\"fixed-case\">SPK<\/jats:styled-content>) transplantation. Patients who developed <jats:styled-content style=\"fixed-case\">CF<\/jats:styled-content> after <jats:styled-content style=\"fixed-case\">SPK<\/jats:styled-content> transplantation had significantly higher mortality (56% vs. 18%) and more frequently graft failure (44% vs. 13%). Recipients with <jats:styled-content style=\"fixed-case\">CF<\/jats:styled-content> also experienced acute rejections more frequently (78% vs. 41%). They furthermore had higher pre\u2010transplant values of HbA<jats:sub>1c<\/jats:sub>, received cyclosporine and azathioprine more often, and had significantly higher cumulative corticosteroid use. Patients transplanted in an earlier era (1992\u20131998) received cyclosporine and azathioprine more often and had a significantly higher cumulative corticosteroid use with the higher prevalence of <jats:styled-content style=\"fixed-case\">CF<\/jats:styled-content>. Conversely, patients with diabetes transplanted more recently (1999\u20132012) received lower doses of corticosteroids as part of their tacrolimus\u2010based immunosuppressive therapy, resulting in fewer <jats:styled-content style=\"fixed-case\">CF<\/jats:styled-content> attacks. In conclusion, development of <jats:styled-content style=\"fixed-case\">CF<\/jats:styled-content> after <jats:styled-content style=\"fixed-case\">SPK<\/jats:styled-content> is associated with poor patient and graft outcome. Poor pre\u2010transplant diabetic control and the use of high\u2010dose corticosteroids are risk factors for the development of <jats:styled-content style=\"fixed-case\">CF<\/jats:styled-content>. We recommend reduction in or even total avoidance of corticosteroids after <jats:styled-content style=\"fixed-case\">SPK<\/jats:styled-content> transplantation. Given the importance of the diagnosis of <jats:styled-content style=\"fixed-case\">CF<\/jats:styled-content> on outcome, a systematic examination of <jats:styled-content style=\"fixed-case\">SPK<\/jats:styled-content> patients' feet is recommended.<\/jats:p>","DOI":"10.1111\/ctr.12572","type":"journal-article","created":{"date-parts":[[2015,5,29]],"date-time":"2015-05-29T19:12:44Z","timestamp":1432926764000},"page":"712-719","source":"Crossref","is-referenced-by-count":23,"title":["Charcot neuroarthropathy after simultaneous pancreas\u2013kidney transplantation: risk factors, prevalence, and outcome"],"prefix":"10.1111","volume":"29","author":[{"given":"Fernando","family":"Garc\u00eda Barrado","sequence":"first","affiliation":[{"name":"Department of Orthopaedics &amp; Diabetic Foot Clinic University Hospitals Leuven Leuven Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dirk R.","family":"Kuypers","sequence":"additional","affiliation":[{"name":"Department of Nephrology and Renal Transplantation University Hospitals Leuven Leuven Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giovanni A.","family":"Matricali","sequence":"additional","affiliation":[{"name":"Department of Orthopaedics &amp; Diabetic Foot Clinic University Hospitals Leuven Leuven Belgium"},{"name":"Department of Development and Regeneration KU Leuven Leuven Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,7,14]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.4239\/wjd.v2.i5.59"},{"key":"e_1_2_6_3_1","first-page":"1014","article-title":"Charcot neuroarthropathy of the foot in the diabetic patient: do not delay the diagnosis and management","volume":"2","author":"Coughlin MJ","year":"2007","journal-title":"Surg Foot Ankle"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc10-1303"},{"key":"e_1_2_6_5_1","doi-asserted-by":"crossref","first-page":"S4\u2013S8","DOI":"10.1002\/dmrr.451","article-title":"The Charcot foot: historical perspective 1827\u20132003","volume":"20","author":"Sanders LJ","year":"2004","journal-title":"Diabetes Metab Res Rev"},{"key":"e_1_2_6_6_1","doi-asserted-by":"crossref","first-page":"996","DOI":"10.1177\/014107688307601203","article-title":"Foot blood flow in diabetic neuropathy","volume":"76","author":"Watkins PJ","year":"1983","journal-title":"J R Soc Med"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.3402\/dfa.v4i0.20872"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cpm.2007.10.006"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc09-1497"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jdiacomp.2011.02.001"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc08-1695"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1755-6686.2012.00269.x"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00125-013-2888-y"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-6143.2005.01069.x"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.tp.0000244730.95416.c6"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1097\/TP.0b013e31825cadbb"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00198-007-0394-0"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1097\/TP.0b013e3182985468"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1038\/ki.1997.297"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1359\/jbmr.091025"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/1753-0407.12090"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00198-006-0253-4"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.2337\/diacare.22.7.1196"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1464-5491.2011.03286.x"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrendo.2011.233"},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.1097\/00007890-199806150-00007"},{"key":"e_1_2_6_27_1","doi-asserted-by":"publisher","DOI":"10.1097\/00007890-199712270-00011"},{"key":"e_1_2_6_28_1","doi-asserted-by":"publisher","DOI":"10.1097\/00007890-199704150-00013"},{"key":"e_1_2_6_29_1","doi-asserted-by":"publisher","DOI":"10.1097\/TP.0b013e31824215b7"},{"key":"e_1_2_6_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.transproceed.2005.05.022"},{"key":"e_1_2_6_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0041-1345(98)00282-6"},{"issue":"2","key":"e_1_2_6_32_1","doi-asserted-by":"crossref","first-page":"1359","DOI":"10.1111\/j.1600-6143.2006.01781.x","article-title":"Kidney and pancreas transplantation in the United States, 1996\u20132005","volume":"7","author":"Andreoni KA","year":"2007","journal-title":"Am J Transplant"}],"container-title":["Clinical Transplantation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fctr.12572","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ctr.12572","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,2]],"date-time":"2023-10-02T12:27:43Z","timestamp":1696249663000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/ctr.12572"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,7,14]]},"references-count":31,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2015,8]]}},"alternative-id":["10.1111\/ctr.12572"],"URL":"https:\/\/doi.org\/10.1111\/ctr.12572","archive":["Portico"],"relation":{},"ISSN":["0902-0063","1399-0012"],"issn-type":[{"value":"0902-0063","type":"print"},{"value":"1399-0012","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,7,14]]}}}