{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,21]],"date-time":"2026-06-21T01:58:12Z","timestamp":1782007092084,"version":"3.54.5"},"reference-count":20,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2015,7,30]],"date-time":"2015-07-30T00:00:00Z","timestamp":1438214400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Transplantation"],"published-print":{"date-parts":[[2015,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Multidrug\u2010resistant (<jats:styled-content style=\"fixed-case\">MDR<\/jats:styled-content>) gram\u2010negative bacteria are a growing threat to solid organ transplantation (<jats:styled-content style=\"fixed-case\">SOT<\/jats:styled-content>) patients in the intensive care unit (<jats:styled-content style=\"fixed-case\">ICU<\/jats:styled-content>). We aimed to examine the mortality rates of gram\u2010negative <jats:styled-content style=\"fixed-case\">MDR<\/jats:styled-content> bacterial infection in <jats:styled-content style=\"fixed-case\">SOT<\/jats:styled-content> patients compared with patient population undergoing other cardiothoracic surgeries and hospitalized under similar <jats:styled-content style=\"fixed-case\">ICU<\/jats:styled-content> conditions.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A retrospective study from a single medical center, including patients with <jats:styled-content style=\"fixed-case\">MDR<\/jats:styled-content><jats:italic>Acinetobacter baumannii<\/jats:italic> and carbapenem\u2010resistant <jats:italic>Klebsiella pneumoniae<\/jats:italic> infection, hospitalized in the cardiothoracic <jats:styled-content style=\"fixed-case\">ICU<\/jats:styled-content>. Data were collected from computerized databases, and data were verified using the hospitalization files. Microbiological data were provided by the microbiology laboratory.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>During the study period, 205 <jats:styled-content style=\"fixed-case\">SOT<\/jats:styled-content> patients and 5031 other patients were hospitalized in the cardiothoracic <jats:styled-content style=\"fixed-case\">ICU<\/jats:styled-content>. Active infection with gram\u2010negative <jats:styled-content style=\"fixed-case\">MDR<\/jats:styled-content> bacteria was identified in 147 patients, of which 37 underwent <jats:styled-content style=\"fixed-case\">SOT<\/jats:styled-content> (18% of total transplant recipients) and 110 underwent another cardiothoracic surgery (2% of total patients who are not transplant recipients). Mortality rates were high among both groups of patients, with no significant difference between them.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Infection with resistant bacteria is more prevalent among patients following <jats:styled-content style=\"fixed-case\">SOT<\/jats:styled-content> compared with patients following other cardiothoracic surgeries. Mortality is high in all patients regardless of the immunocompromised condition.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ctr.12575","type":"journal-article","created":{"date-parts":[[2015,6,10]],"date-time":"2015-06-10T13:06:54Z","timestamp":1433941614000},"page":"756-762","source":"Crossref","is-referenced-by-count":23,"title":["Multidrug\u2010resistant <i>Acinetobacter baumannii<\/i> infections in lung transplant patients in the cardiothoracic intensive care unit"],"prefix":"10.1111","volume":"29","author":[{"given":"P.","family":"Biderman","sequence":"first","affiliation":[{"name":"Cardio\u2010Thoracic Intensive Care Unit Rabin Medical Center Petach\u2010Tikva Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Y.","family":"Bugaevsky","sequence":"additional","affiliation":[{"name":"Internal Medicine B Rabin Medical Center Petach\u2010Tikva Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H.","family":"Ben\u2010Zvi","sequence":"additional","affiliation":[{"name":"Microbiology Laboratory Rabin Medical Center Petach\u2010Tikva Israel"},{"name":"The Sackler Faculty of Medicine Tel\u2010Aviv University Tel\u2010Aviv Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Bishara","sequence":"additional","affiliation":[{"name":"The Sackler Faculty of Medicine Tel\u2010Aviv University Tel\u2010Aviv Israel"},{"name":"Infectious Diseases Unit Rabin Medical Center Petach\u2010Tikva Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E.","family":"Goldberg","sequence":"additional","affiliation":[{"name":"The Sackler Faculty of Medicine Tel\u2010Aviv University Tel\u2010Aviv Israel"},{"name":"Infectious Diseases Unit Rabin Medical Center Petach\u2010Tikva Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,7,30]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1086\/432803"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.diagmicrobio.2006.07.009"},{"key":"e_1_2_7_4_1","first-page":"21","article-title":"Annual trends in antibiotic resistance of nosocomial Acinetobacter baumannii strains and the effect of synergistic antibiotic combinations","volume":"27","author":"Tatman\u2010Otkun M","year":"2004","journal-title":"New Microbiol"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.3201\/eid1301.060716"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhin.2005.01.007"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1086\/500936"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.3201\/eid1101.040001"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.39.1.389-391.2001"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0195-6701(03)00046-X"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-3062.2011.00688.x"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.diagmicrobio.2009.08.020"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1086\/374337"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00134-005-2691-4"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2334-12-351"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1089\/sur.2006.029"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/0196-6553(88)90053-3"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/tid.12001"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-3062.2009.00445.x"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00408-010-9250-7"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciu789"}],"container-title":["Clinical Transplantation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fctr.12575","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ctr.12575","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,24]],"date-time":"2023-09-24T17:00:40Z","timestamp":1695574840000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/ctr.12575"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,7,30]]},"references-count":20,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2015,9]]}},"alternative-id":["10.1111\/ctr.12575"],"URL":"https:\/\/doi.org\/10.1111\/ctr.12575","archive":["Portico"],"relation":{},"ISSN":["0902-0063","1399-0012"],"issn-type":[{"value":"0902-0063","type":"print"},{"value":"1399-0012","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,7,30]]}}}