{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,17]],"date-time":"2026-07-17T15:33:44Z","timestamp":1784302424436,"version":"3.55.0"},"reference-count":37,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2015,10,5]],"date-time":"2015-10-05T00:00:00Z","timestamp":1444003200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100004336","name":"Novartis","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004336","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100002491","name":"Bristol-Myers Squibb","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100002491","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100004319","name":"Pfizer","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004319","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100004324","name":"Astellas Pharma US","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004324","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007560","name":"Chiesi Farmaceutici","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007560","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Transplantation"],"published-print":{"date-parts":[[2015,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:styled-content style=\"fixed-case\">ABO<\/jats:styled-content>\u2010incompatible (<jats:styled-content style=\"fixed-case\">ABO<\/jats:styled-content><jats:italic>i<\/jats:italic>) kidney transplantation (<jats:styled-content style=\"fixed-case\">KT<\/jats:styled-content>x) has become an accepted therapeutic option in renal replacement therapy for patients without a blood group\u2010compatible living donor. Using different desensitization strategies, most centers apply B\u2010cell depletion with rituximab and maintenance immunosuppression (<jats:styled-content style=\"fixed-case\">IS<\/jats:styled-content>) with tacrolimus and mycophenolic acid. This high load of total <jats:styled-content style=\"fixed-case\">IS<\/jats:styled-content> leads to an increased rate of surgical complications and virus infections in <jats:styled-content style=\"fixed-case\">ABO<\/jats:styled-content><jats:italic>i<\/jats:italic> patients. Our aim was to establish <jats:styled-content style=\"fixed-case\">ABO<\/jats:styled-content><jats:italic>i <\/jats:italic><jats:styled-content style=\"fixed-case\">KT<\/jats:styled-content>x using an immunosuppressive regimen, which is effective in preventing acute rejection without increasing the risk for viral infections. Therefore, we selected a <jats:italic>de novo<\/jats:italic> immunosuppressive protocol with low\u2010dose calcineurin inhibitor and the <jats:styled-content style=\"fixed-case\">mTOR<\/jats:styled-content> inhibitor everolimus for our <jats:styled-content style=\"fixed-case\">ABO<\/jats:styled-content><jats:italic>i<\/jats:italic> program. Here, we report the first 25 patients with a complete three\u2010yr follow\u2010up treated with this regimen. Three\u2010yr patient survival and graft survival were 96% and 83%. The rate of acute T\u2010cell\u2010mediated rejections was low (12%). Cytomegalovirus (<jats:styled-content style=\"fixed-case\">CMV<\/jats:styled-content>) infection was evident in one patient only (4%). Surgical complications were common (40%), but mild in 80% of cases. We demonstrate that <jats:styled-content style=\"fixed-case\">ABO<\/jats:styled-content><jats:italic>i <\/jats:italic><jats:styled-content style=\"fixed-case\">KT<\/jats:styled-content>x with a <jats:italic>de novo<\/jats:italic> m<jats:styled-content style=\"fixed-case\">TOR<\/jats:styled-content> inhibitor\u2010based regimen is feasible without severe surgical or immunological complications and a low rate of viral infections.<\/jats:p>","DOI":"10.1111\/ctr.12624","type":"journal-article","created":{"date-parts":[[2015,9,3]],"date-time":"2015-09-03T07:59:17Z","timestamp":1441267157000},"page":"1021-1028","source":"Crossref","is-referenced-by-count":16,"title":["<i>De novo<\/i> m<scp>TOR<\/scp> inhibitor\u2010based immunosuppression in <scp>ABO<\/scp>\u2010incompatible kidney transplantation"],"prefix":"10.1111","volume":"29","author":[{"given":"Martina","family":"Koch","sequence":"first","affiliation":[{"name":"Department of Hepatobiliary Surgery and Transplantation Universit\u00e4tsklinikum Hamburg Eppendorf Hamburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thorsten","family":"Wiech","sequence":"additional","affiliation":[{"name":"Section Nephropathology Institute of Pathology Universit\u00e4tsklinikum Hamburg Eppendorf Hamburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthias","family":"Marget","sequence":"additional","affiliation":[{"name":"HLA Laboratory Institute of Transfusion Medicine Universit\u00e4tsklinikum Hamburg Eppendorf Hamburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sven","family":"Peine","sequence":"additional","affiliation":[{"name":"HLA Laboratory Institute of Transfusion Medicine Universit\u00e4tsklinikum Hamburg Eppendorf Hamburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hansj\u00f6rg","family":"Thude","sequence":"additional","affiliation":[{"name":"Department of Hepatobiliary Surgery and Transplantation Universit\u00e4tsklinikum Hamburg Eppendorf Hamburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eike G.","family":"Achilles","sequence":"additional","affiliation":[{"name":"Department of Hepatobiliary Surgery and Transplantation Universit\u00e4tsklinikum Hamburg Eppendorf Hamburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lutz","family":"Fischer","sequence":"additional","affiliation":[{"name":"Department of Hepatobiliary Surgery and Transplantation Universit\u00e4tsklinikum Hamburg Eppendorf Hamburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anja","family":"Lehnhardt","sequence":"additional","affiliation":[{"name":"Department of Hepatobiliary Surgery and Transplantation Universit\u00e4tsklinikum Hamburg Eppendorf Hamburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Friedrich","family":"Thaiss","sequence":"additional","affiliation":[{"name":"III. Medical Clinic\/Nephrology Universit\u00e4tsklinikum Hamburg Eppendorf Hamburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bjoern","family":"Nashan","sequence":"additional","affiliation":[{"name":"Department of Hepatobiliary Surgery and Transplantation Universit\u00e4tsklinikum Hamburg Eppendorf Hamburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,10,5]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.tp.0000262570.18117.55"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.TP.0000078622.43689.D4"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gfr215"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.2215\/CJN.03710411"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/ctr.12288"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gfm646"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.2215\/CJN.00920207"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1097\/TP.0b013e318169c794"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gfm648"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1097\/TP.0b013e318276a1ef"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1097\/TP.0b013e31824810e6"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-6143.2005.01063.x"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1097\/00007691-200202000-00010"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.tp.0000219703.39149.85"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.sla.0000133083.54934.ae"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/ajt.12590"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-6143.2004.00464.x"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1097\/00007890-199801270-00014"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.tp.0000296008.08452.4c"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-6143.2006.01676.x"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gfn478"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gfn671"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-6143.2011.03674.x"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.TP.0000140486.97461.49"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1097\/TP.0b013e3181bb43ec"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1097\/TP.0b013e318245b2af"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-6143.2011.03584.x"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1097\/00007890-200203150-00017"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1432-2277.2006.00354.x"},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-6143.2003.00051.x"},{"key":"e_1_2_7_32_1","doi-asserted-by":"publisher","DOI":"10.1097\/TP.0000000000000029"},{"key":"e_1_2_7_33_1","doi-asserted-by":"publisher","DOI":"10.1111\/ctr.12513"},{"key":"e_1_2_7_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jss.2011.05.030"},{"key":"e_1_2_7_35_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.TP.0000093502.26208.42"},{"key":"e_1_2_7_36_1","doi-asserted-by":"publisher","DOI":"10.1097\/TP.0b013e3182551021"},{"key":"e_1_2_7_37_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-6143.2010.03129.x"},{"key":"e_1_2_7_38_1","doi-asserted-by":"publisher","DOI":"10.1111\/tri.12412"}],"container-title":["Clinical Transplantation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fctr.12624","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ctr.12624","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,3]],"date-time":"2023-10-03T15:41:43Z","timestamp":1696347703000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/ctr.12624"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,10,5]]},"references-count":37,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2015,11]]}},"alternative-id":["10.1111\/ctr.12624"],"URL":"https:\/\/doi.org\/10.1111\/ctr.12624","archive":["Portico"],"relation":{},"ISSN":["0902-0063","1399-0012"],"issn-type":[{"value":"0902-0063","type":"print"},{"value":"1399-0012","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,10,5]]}}}