{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,5]],"date-time":"2026-11-05T23:57:08Z","timestamp":1793923028213,"version":"4.8.0"},"reference-count":32,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2015,11,4]],"date-time":"2015-11-04T00:00:00Z","timestamp":1446595200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Transplantation"],"published-print":{"date-parts":[[2015,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Patients with idiopathic pulmonary arterial hypertension (<jats:styled-content style=\"fixed-case\">IPAH<\/jats:styled-content>) have improved survival after heart\u2013lung transplantation (<jats:styled-content style=\"fixed-case\">HLT<\/jats:styled-content>) and double\u2010lung transplantation (<jats:styled-content style=\"fixed-case\">DLT<\/jats:styled-content>). However, the optimal procedure for patients with <jats:styled-content style=\"fixed-case\">IPAH<\/jats:styled-content> undergoing transplantation remains unclear. We hypothesized that critically ill <jats:styled-content style=\"fixed-case\">IPAH<\/jats:styled-content> patients, defined by admission to the intensive care units (<jats:styled-content style=\"fixed-case\">ICU<\/jats:styled-content>), would demonstrate improved survival with <jats:styled-content style=\"fixed-case\">HLT<\/jats:styled-content> vs. <jats:styled-content style=\"fixed-case\">DLT<\/jats:styled-content>. All adult <jats:styled-content style=\"fixed-case\">IPAH<\/jats:styled-content> patients (&gt;18 yr) in the Scientific Registry of Transplant Recipients (<jats:styled-content style=\"fixed-case\">SRTR<\/jats:styled-content>) database, who underwent either <jats:styled-content style=\"fixed-case\">HLT<\/jats:styled-content> or <jats:styled-content style=\"fixed-case\">DLT<\/jats:styled-content> between 1987 and 2012, were included. Baseline characteristics, survival, and adjusted survival were compared between the <jats:styled-content style=\"fixed-case\">HLT<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">DLT<\/jats:styled-content> groups. Similar analyses were performed for the subgroups as defined by the recipients' hospitalization status. A total of 928 <jats:styled-content style=\"fixed-case\">IPAH<\/jats:styled-content> patients (667 <jats:styled-content style=\"fixed-case\">DLT<\/jats:styled-content>, 261 <jats:styled-content style=\"fixed-case\">HLT<\/jats:styled-content>) were included in this analysis. The <jats:styled-content style=\"fixed-case\">HLT<\/jats:styled-content> recipients were younger, more likely to be admitted to the <jats:styled-content style=\"fixed-case\">ICU<\/jats:styled-content>, and have had their transplant in previous eras. Overall, the adjusted survivals after <jats:styled-content style=\"fixed-case\">HLT<\/jats:styled-content> or <jats:styled-content style=\"fixed-case\">DLT<\/jats:styled-content> were similar. For recipients who were hospitalized in the <jats:styled-content style=\"fixed-case\">ICU<\/jats:styled-content>,<jats:styled-content style=\"fixed-case\"> DLT<\/jats:styled-content> was associated with worse outcomes (<jats:styled-content style=\"fixed-case\">HR<\/jats:styled-content> 1.827; 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> 1.018\u20133.279). In <jats:styled-content style=\"fixed-case\">IPAH<\/jats:styled-content> patients, the overall survival after <jats:styled-content style=\"fixed-case\">HLT<\/jats:styled-content> or <jats:styled-content style=\"fixed-case\">DLT<\/jats:styled-content> is comparable. <jats:styled-content style=\"fixed-case\">HLT<\/jats:styled-content> may provide improved outcomes in critically ill <jats:styled-content style=\"fixed-case\">IPAH<\/jats:styled-content> patients admitted to the <jats:styled-content style=\"fixed-case\">ICU<\/jats:styled-content> at time of transplantation.<\/jats:p>","DOI":"10.1111\/ctr.12628","type":"journal-article","created":{"date-parts":[[2015,9,11]],"date-time":"2015-09-11T08:37:02Z","timestamp":1441960622000},"page":"1067-1075","source":"Crossref","is-referenced-by-count":45,"title":["Heart\u2013lung vs. double\u2010lung transplantation for idiopathic pulmonary arterial hypertension"],"prefix":"10.1111","volume":"29","author":[{"given":"Charles","family":"Hill","sequence":"first","affiliation":[{"name":"Department of Anesthesiology Perioperative and Pain Medicine Stanford University School of Medicine Stanford CA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bryan","family":"Maxwell","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology and Critical Care Medicine Johns Hopkins University School of Medicine Baltimore MD USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Boulate","sequence":"additional","affiliation":[{"name":"Department of Thoracic and Vascular Surgery and Heart\u2010Lung Transplantation Centre Chirurgical Marie Lannelongue Le Plessis\u2010Robinson Paris\u2010Sud University Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francois","family":"Haddad","sequence":"additional","affiliation":[{"name":"Department of Medicine Stanford University School of Medicine Stanford CA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard","family":"Ha","sequence":"additional","affiliation":[{"name":"Department of Cardiothoracic Surgery Stanford University School of Medicine Stanford CA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kamyar","family":"Afshar","sequence":"additional","affiliation":[{"name":"Keck School of Medicine USC Los Angeles CA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Weill","sequence":"additional","affiliation":[{"name":"Department of Medicine Stanford University School of Medicine Stanford CA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gundeep S.","family":"Dhillon","sequence":"additional","affiliation":[{"name":"Department of Medicine Stanford University School of Medicine Stanford CA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,11,4]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.112.001080"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.healun.2006.03.011"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2013.06.032"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198203113061001"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0003-4975(99)00176-9"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.healun.2011.08.004"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/0003-4975(95)00365-R"},{"key":"e_1_2_8_9_1","first-page":"II312","article-title":"Magnetic resonance imaging provides evidence for remodeling of the right ventricle after single\u2010lung transplantation for pulmonary 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