{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,14]],"date-time":"2026-02-14T03:32:26Z","timestamp":1771039946460,"version":"3.50.1"},"reference-count":49,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2015,11,24]],"date-time":"2015-11-24T00:00:00Z","timestamp":1448323200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Transplantation"],"published-print":{"date-parts":[[2016,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>Patent foramen ovale (<jats:styled-content style=\"fixed-case\">PFO<\/jats:styled-content>) is a common atrial septal defect that is largely asymptomatic and often undiagnosed. The impact of a<jats:styled-content style=\"fixed-case\">PFO<\/jats:styled-content>in patients undergoing liver transplantation (<jats:styled-content style=\"fixed-case\">LT<\/jats:styled-content>) is unknown.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>Assess the impact of<jats:styled-content style=\"fixed-case\">PFO<\/jats:styled-content>and physiologic intrapulmonary shunt (<jats:styled-content style=\"fixed-case\">IPS<\/jats:styled-content>) on the perioperative outcomes of patients who underwent<jats:styled-content style=\"fixed-case\">LT<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We performed a retrospective, intention\u2010to\u2010treat analysis of patients with<jats:styled-content style=\"fixed-case\">PFO<\/jats:styled-content>and controls without<jats:styled-content style=\"fixed-case\">PFO<\/jats:styled-content>who underwent<jats:styled-content style=\"fixed-case\">LT<\/jats:styled-content>at Mayo Clinic in Florida between 2008 and 2013. Patients with physiologic<jats:styled-content style=\"fixed-case\">IPS<\/jats:styled-content>were also analyzed. The cohorts were compared for baseline characteristics, length of stay in the intensive care unit (<jats:styled-content style=\"fixed-case\">ICU<\/jats:styled-content>), postoperative oxygen requirements, 30\u2010d cerebrovascular accidents, and mortality.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of the 935 patients who underwent<jats:styled-content style=\"fixed-case\">LT<\/jats:styled-content>, 10.4% had proven<jats:styled-content style=\"fixed-case\">PFO<\/jats:styled-content>by pre\u2010<jats:styled-content style=\"fixed-case\">LT<\/jats:styled-content>echocardiogram. Control patients (n = 101) were statistically older than<jats:styled-content style=\"fixed-case\">PFO<\/jats:styled-content>and<jats:styled-content style=\"fixed-case\">IPS<\/jats:styled-content>(n = 56) patients, but similar in sex,<jats:styled-content style=\"fixed-case\">BMI<\/jats:styled-content>, Model for End\u2010stage Liver Disease score, American Society of Anesthesiologist score, and left ventricular ejection fraction.<jats:styled-content style=\"fixed-case\">PFO<\/jats:styled-content>and<jats:styled-content style=\"fixed-case\">IPS<\/jats:styled-content>patients had similar length of stay in the<jats:styled-content style=\"fixed-case\">ICU<\/jats:styled-content>, mechanical ventilation times, post\u2010<jats:styled-content style=\"fixed-case\">LT<\/jats:styled-content>oxygen requirements, and 30\u2010d mortality compared to controls. Subgroup analysis showed similar outcomes for large<jats:styled-content style=\"fixed-case\">PFO<\/jats:styled-content>and<jats:styled-content style=\"fixed-case\">IPS<\/jats:styled-content>patients to controls.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The presence of<jats:styled-content style=\"fixed-case\">PFO<\/jats:styled-content>did not have a negative impact on perioperative<jats:styled-content style=\"fixed-case\">LT<\/jats:styled-content>outcomes.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ctr.12643","type":"journal-article","created":{"date-parts":[[2015,10,8]],"date-time":"2015-10-08T15:51:11Z","timestamp":1444319471000},"page":"26-32","source":"Crossref","is-referenced-by-count":20,"title":["Patent foramen ovale in liver transplant recipients does not negatively impact short\u2010term outcomes"],"prefix":"10.1111","volume":"30","author":[{"given":"Monia E.","family":"Werlang","sequence":"first","affiliation":[{"name":"Department of Internal 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