{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T12:01:23Z","timestamp":1792065683540,"version":"4.4.0"},"reference-count":33,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2016,1,5]],"date-time":"2016-01-05T00:00:00Z","timestamp":1451952000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Transplantation"],"published-print":{"date-parts":[[2016,2]]},"abstract":"Abstract<\/jats:title>Background<\/jats:title>A<\/jats:bold>ntibody\u2010mediated rejection (AMR<\/jats:styled-content>) can induce and develop thrombotic microangiopathy (TMA<\/jats:styled-content>) in renal allografts. A definitive AMR<\/jats:styled-content> (dAMR<\/jats:styled-content>) co\u2010presents three diagnostic features. A suspicious AMR<\/jats:styled-content> (sAMR<\/jats:styled-content>) is designated when one of the three features is missing.<\/jats:p><\/jats:sec>Methods<\/jats:title>Thirty\u2010two TMA<\/jats:styled-content> cases overlapping with AMR<\/jats:styled-content> (AMR<\/jats:styled-content>+ TMA<\/jats:styled-content>) were studied, which involved 14 cases of sAMR<\/jats:styled-content>+ TMA<\/jats:styled-content> and 18 cases of dAMR<\/jats:styled-content>+ TMA<\/jats:styled-content>. Thirty TMA<\/jats:styled-content> cases free of AMR<\/jats:styled-content> features (AMR<\/jats:styled-content>\u2212 TMA<\/jats:styled-content>) were enrolled as control group.<\/jats:p><\/jats:sec>Results<\/jats:title>The ratio of complete response to treatment was similar between AMR<\/jats:styled-content>\u2212 TMA<\/jats:styled-content> and AMR<\/jats:styled-content>+ TMA<\/jats:styled-content> group (23.3% vs. 12.5%, p = 0.33), or between sAMR<\/jats:styled-content>+ TMA<\/jats:styled-content> and dAMR<\/jats:styled-content>+ TMA<\/jats:styled-content> group (14.3% vs. 11.1%, p = 0.79). At eight yr post\u2010transplantation, the death\u2010censored graft survival (DCGS<\/jats:styled-content>) rate of AMR<\/jats:styled-content>\u2212 TMA<\/jats:styled-content> group was 62.8%, which was significantly higher than 28.0% of AMR<\/jats:styled-content>+ TMA<\/jats:styled-content> group (p = 0.01), but similar between sAMR<\/jats:styled-content>+ TMA<\/jats:styled-content> and dAMR<\/jats:styled-content>+ TMA<\/jats:styled-content> group (30.0% vs. 26.7%, p = 0.92). Overall, the intimal arteritis and the broad HLA<\/jats:styled-content> (Human leukocyte antigens) mismatches were closely associated with over time renal allograft failure.<\/jats:p><\/jats:sec>Conclusion<\/jats:title>The AMR<\/jats:styled-content>+ TMA<\/jats:styled-content> has inferior long\u2010term graft survival, but grafts with sAMR<\/jats:styled-content>+ TMA<\/jats:styled-content> or dAMR<\/jats:styled-content>+ TMA<\/jats:styled-content> have similar characteristics and clinical courses.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ctr.12645","type":"journal-article","created":{"date-parts":[[2015,10,8]],"date-time":"2015-10-08T15:51:12Z","timestamp":1444319472000},"page":"105-117","source":"Crossref","is-referenced-by-count":27,"title":["The inferior impact of antibody\u2010mediated rejection on the clinical outcome of kidney allografts that develop de novo<\/i> thrombotic microangiopathy"],"prefix":"10.1111","volume":"30","author":[{"given":"Kaiyin","family":"Wu","sequence":"first","affiliation":[{"name":"Medizinische Klinik mit Schwerpunkt Nephrologie Universit\u00e4tsmedizin Berlin Charit\u00e9 Campus Mitte Berlin Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Klemens","family":"Budde","sequence":"additional","affiliation":[{"name":"Medizinische Klinik mit Schwerpunkt Nephrologie Universit\u00e4tsmedizin Berlin Charit\u00e9 Campus Mitte Berlin Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Danilo","family":"Schmidt","sequence":"additional","affiliation":[{"name":"Medizinische Klinik mit Schwerpunkt Nephrologie Universit\u00e4tsmedizin Berlin Charit\u00e9 Campus Mitte Berlin Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hans\u2010Hellmut","family":"Neumayer","sequence":"additional","affiliation":[{"name":"Medizinische Klinik mit Schwerpunkt Nephrologie 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