{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,5,26]],"date-time":"2024-05-26T22:51:15Z","timestamp":1716763875122},"reference-count":24,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2015,11,3]],"date-time":"2015-11-03T00:00:00Z","timestamp":1446508800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Transplantation"],"published-print":{"date-parts":[[2015,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The immune response after allogenic transplantation is a complex phenomenon involving cytokines, chemokines, and other mediators of inflammation. The aim of this study was to evaluate the influence of the <jats:italic><jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>17A<\/jats:italic> and <jats:italic><jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>17F<\/jats:italic> gene polymorphisms on long\u2010term kidney allograft function, graft function loss\/return to dialysis, and mortality after kidney transplantation. This study enrolled 269 Caucasian deceased donor renal transplant recipients. The rs2275913:G&gt;A (\u2212197G&gt;A) polymorphism within the <jats:italic><jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>17A<\/jats:italic> gene promoter and rs2397084:T&gt;C (Glu126Gly), rs11465553:G&gt;A (Val155Ile), and rs763780:T&gt;C (His167Arg) polymorphisms within the <jats:italic><jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>17F<\/jats:italic> gene were genotyped. Creatinine concentrations 12, 24, 36, 48, and 60 months after transplantation were significantly higher in recipients with the rs2275913:A&gt;G <jats:italic><jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>17A<\/jats:italic> <jats:styled-content style=\"fixed-case\">GG<\/jats:styled-content> genotype (<jats:styled-content style=\"fixed-case\">GG<\/jats:styled-content> vs. <jats:styled-content style=\"fixed-case\">GA<\/jats:styled-content> + <jats:styled-content style=\"fixed-case\">AA<\/jats:styled-content>: p = 0.03, p = 0.004, p = 0.006, p = 0.03, p = 0.04, respectively). Moreover, the <jats:styled-content style=\"fixed-case\">GG<\/jats:styled-content> genotype was statistically significantly associated with increased risk of delayed graft function. This association remained significant in multivariate regression analysis adjusted for recipients' age and sex. In the case of the rs11465553, <jats:italic><jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>17F<\/jats:italic> univariate Cox regression analysis showed statistically significant association of <jats:styled-content style=\"fixed-case\">GA<\/jats:styled-content> genotype with higher risk of graft loss\/return to dialysis (<jats:styled-content style=\"fixed-case\">GA<\/jats:styled-content> vs. <jats:styled-content style=\"fixed-case\">GG<\/jats:styled-content>:<jats:styled-content style=\"fixed-case\"> HR<\/jats:styled-content> = 2.795, 95%<jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> = 1.031\u20137.579, p = 0.04). The results of our study suggest that the <jats:styled-content style=\"fixed-case\">GG<\/jats:styled-content> genotype of the rs2275913 <jats:italic><jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>17A<\/jats:italic> gene promoter polymorphism is associated with significantly impaired long\u2010term kidney allograft function, whereas the <jats:styled-content style=\"fixed-case\">GA<\/jats:styled-content> genotype of the rs11465553 <jats:italic><jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>17F<\/jats:italic> gene polymorphism may be associated with a significantly higher risk of graft function loss and return to dialysis after kidney transplantation.<\/jats:p>","DOI":"10.1111\/ctr.12649","type":"journal-article","created":{"date-parts":[[2015,10,8]],"date-time":"2015-10-08T14:15:47Z","timestamp":1444313747000},"page":"1187-1194","source":"Crossref","is-referenced-by-count":6,"title":["Influence of the <i><scp>IL1<\/scp>7<scp>A<\/scp><\/i> and <i><scp>IL1<\/scp>7<scp>F<\/scp><\/i> gene polymorphisms on the long\u2010term kidney allograft function and return to dialysis after kidney transplantation"],"prefix":"10.1111","volume":"29","author":[{"given":"Maciej","family":"Romanowski","sequence":"first","affiliation":[{"name":"Clinical Department of Nephrology, Transplantology and Internal Medicine Pomeranian Medical University Szczecin Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karolina","family":"K\u0142oda","sequence":"additional","affiliation":[{"name":"Clinical Department of Nephrology, Transplantology and Internal Medicine Pomeranian Medical University Szczecin Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bogumi\u0142a","family":"Os\u0119kowska","sequence":"additional","affiliation":[{"name":"Clinical Department of Nephrology, Transplantology and Internal Medicine Pomeranian Medical University Szczecin Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Leszek","family":"Doma\u0144ski","sequence":"additional","affiliation":[{"name":"Clinical Department of Nephrology, Transplantology and Internal Medicine Pomeranian Medical University Szczecin Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrzej","family":"Pawlik","sequence":"additional","affiliation":[{"name":"Department of Physiology Pomeranian Medical University Szczecin Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Krzysztof","family":"Safranow","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Medical Chemistry Pomeranian Medical University Szczecin Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kazimierz","family":"Ciechanowski","sequence":"additional","affiliation":[{"name":"Clinical Department of Nephrology, Transplantology and Internal Medicine Pomeranian Medical University Szczecin 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