{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,28]],"date-time":"2025-10-28T05:52:17Z","timestamp":1761630737959,"version":"3.41.0"},"reference-count":21,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2015,11,18]],"date-time":"2015-11-18T00:00:00Z","timestamp":1447804800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Transplantation"],"published-print":{"date-parts":[[2015,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The aim of this study was to see whether lessons could be learned from the prospectively maintained nationwide database on solitary pancreas transplantation (<jats:styled-content style=\"fixed-case\">SPT<\/jats:styled-content>x) performed in the<jats:styled-content style=\"fixed-case\">UK<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Two hundred and forty\u2010five<jats:styled-content style=\"fixed-case\">SPT<\/jats:styled-content>x were utilized from the 2004\u20132013 period (113 pancreas transplant alone and 132 pancreas after kidney). The statistical analysis included donor, recipient, transplant variables, and the effect of a rejection episode on graft survival.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Cold ischemia time (<jats:styled-content style=\"fixed-case\">CIT<\/jats:styled-content>),<jats:styled-content style=\"fixed-case\">CIT<\/jats:styled-content>&gt; 12 h, donor body mass index (<jats:styled-content style=\"fixed-case\">BMI<\/jats:styled-content>) &gt; 30, and non\u2010lymphocyte\u2010depleting induction immunosuppression achieved p\u2010value &lt;0.05 in the unadjusted univariate hazard model analysis. In a multivariate analysis, variables that persisted in demonstrating increased independent risk included<jats:styled-content style=\"fixed-case\">CIT<\/jats:styled-content>&gt; 12 h (hazard ratio [<jats:styled-content style=\"fixed-case\">HR<\/jats:styled-content>] 1.94, p = 0.035) and the use of non\u2010depleting induction immunosuppression (<jats:styled-content style=\"fixed-case\">HR<\/jats:styled-content>1.95, p = 0.002). Factors such as bladder\u2010drained grafts and donor variables including age,<jats:styled-content style=\"fixed-case\">BMI<\/jats:styled-content>, and donation after cardiac death (<jats:styled-content style=\"fixed-case\">DCD<\/jats:styled-content>) vs. donation after brain\u2010stem death did not attain significance. Rejection reduces the overall graft survival by approximately 1000 d (1841 \u00b1 114 d vs. 915 \u00b1 119 d, p = 0.001).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Cold ischemia time &lt;12 h and the use of depleting antibodies as induction immunosuppression have a positive effect on pancreas allograft survival. Other factors such as bladder\u2010drained grafts and donor variables such as age,<jats:styled-content style=\"fixed-case\">BMI<\/jats:styled-content>, and<jats:styled-content style=\"fixed-case\">DCD<\/jats:styled-content>status did not attain significance in a multivariate analysis.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ctr.12650","type":"journal-article","created":{"date-parts":[[2015,10,8]],"date-time":"2015-10-08T14:19:55Z","timestamp":1444313995000},"page":"1195-1202","source":"Crossref","is-referenced-by-count":19,"title":["Solitary pancreas transplantation: a review of the<scp>UK<\/scp>experience over a period of 10 yr"],"prefix":"10.1111","volume":"29","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9108-4064","authenticated-orcid":false,"given":"Georgios","family":"Vrakas","sequence":"first","affiliation":[{"name":"Oxford Transplant Centre Churchill Hospital Oxford UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rubens Macedo","family":"Arantes","sequence":"additional","affiliation":[{"name":"Oxford Transplant Centre Churchill Hospital Oxford UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Undine","family":"Gerlach","sequence":"additional","affiliation":[{"name":"Oxford Transplant Centre Churchill Hospital Oxford UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Srikanth","family":"Reddy","sequence":"additional","affiliation":[{"name":"Oxford Transplant Centre Churchill Hospital Oxford UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter","family":"Friend","sequence":"additional","affiliation":[{"name":"Oxford Transplant Centre Churchill Hospital Oxford UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anil","family":"Vaidya","sequence":"additional","affiliation":[{"name":"Oxford Transplant Centre Churchill Hospital Oxford UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2015,11,18]]},"reference":[{"key":"e_1_2_7_2_1","unstructured":"2009 OPTN\/SRTR Annual Report. US Scientific Registry of Transplant Recipients. 4 May 2009. Available at:http:\/\/www.srtr.org\/annual_reports\/archives\/2009\/2009_Annual_Report\/Retrieved 6 April 2014."},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/SLA.0b013e3181b76d2b"},{"key":"e_1_2_7_4_1","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1111\/j.1399-0012.1998.tb00981.x","article-title":"Quality of life after pancreas transplantation: a review","volume":"12","author":"Gross CR","year":"1998","journal-title":"Clin Transplant"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrendo.2013.138"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-6143.2009.02996.x"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.290.21.2817"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.jrn.2011.10.020"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/ajt.12750"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1097\/MOT.0b013e3283614a5c"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1097\/TP.0b013e3181dda17e"},{"key":"e_1_2_7_12_1","first-page":"455","volume-title":"Solid Organ Transplant Rejection: Mechanisms, Pathology and Diagnosis","author":"Gruessner RWG","year":"1996"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.12659\/AOT.883691"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1097\/MPA.0000000000000084"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1097\/MOT.0b013e32835c29ef"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/ctr.12199"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1900\/RDS.2011.8.6"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/ajt.12624"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-6143.2011.03729.x"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/ctr.12005"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1900\/RDS.2011.8.17"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1097\/MOT.0b013e32835c51b5"}],"container-title":["Clinical Transplantation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fctr.12650","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ctr.12650","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,5,30]],"date-time":"2025-05-30T23:40:08Z","timestamp":1748648408000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/ctr.12650"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,11,18]]},"references-count":21,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2015,12]]}},"alternative-id":["10.1111\/ctr.12650"],"URL":"https:\/\/doi.org\/10.1111\/ctr.12650","archive":["Portico"],"relation":{},"ISSN":["0902-0063","1399-0012"],"issn-type":[{"type":"print","value":"0902-0063"},{"type":"electronic","value":"1399-0012"}],"subject":[],"published":{"date-parts":[[2015,11,18]]}}}