{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,7]],"date-time":"2026-07-07T19:07:40Z","timestamp":1783451260165,"version":"3.55.0"},"reference-count":24,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2015,11,20]],"date-time":"2015-11-20T00:00:00Z","timestamp":1447977600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Transplantation"],"published-print":{"date-parts":[[2016,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To assess the safety and efficacy of allograft nephrectomy vs. no\u2010allograft nephrectomy for renal re\u2010transplantation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Medline (PubMed), Embase, Ovid, Cochrane, and the Chinese Biomedical Literature databases were searched to identify clinically comparable trials that compared allograft nephrectomy (<jats:styled-content style=\"fixed-case\">AN<\/jats:styled-content>) and no\u2010allograft nephrectomy (no\u2010<jats:styled-content style=\"fixed-case\">AN<\/jats:styled-content>) with renal re\u2010transplantation. RevMan 5.1 software and Stat Manager V4.1 software were used for the meta\u2010analysis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Eight trials were included involving 1008 patients. Of these, 508 (50.4%) patients underwent<jats:styled-content style=\"fixed-case\">AN<\/jats:styled-content>and 500 (49.6%) had not undergone<jats:styled-content style=\"fixed-case\">AN<\/jats:styled-content>before re\u2010transplantation. The pooled results revealed that the<jats:styled-content style=\"fixed-case\">AN<\/jats:styled-content>group had a longer time interval between graft loss and re\u2010transplantation of 14.40 months (weighted mean difference (<jats:styled-content style=\"fixed-case\">WMD<\/jats:styled-content>) = 11.23; 95% confidence interval (<jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>): 2.47\u201319.99; p = 0.01). The<jats:styled-content style=\"fixed-case\">AN<\/jats:styled-content>group also had an higher rate of positive<jats:styled-content style=\"fixed-case\">PRA<\/jats:styled-content>(<jats:styled-content style=\"fixed-case\">PRA<\/jats:styled-content>&gt;10%) before re\u2010transplantation (<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content>: odds ratio = 1.62, 95%<jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>= 1.17\u20132.23, p = 0.003). A comparison of serum creatinine (mg\/<jats:styled-content style=\"fixed-case\">dL<\/jats:styled-content>) at one yr after re\u2010transplantation between the groups showed no significant differences (<jats:styled-content style=\"fixed-case\">WMD<\/jats:styled-content>: \u22120.25; 95%<jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>: \u22120.52 to 0.03; p = 0.08). There were neither significant differences in one\u2010yr graft survival rates (<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content>: 0.74; 95%<jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>: 0.31\u20131.72; p = 0.48) nor one\u2010yr patient survival rates (<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content>: 1.60; 95%<jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>: 0.57\u20134.46; p = 0.37) between the groups. Insignificant differences were noted for the rates of acute rejection (<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content>: 1.30; 95%<jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>: 0.89\u20131.91; p = 0.17) and post\u2010operative complications (<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content>: 1.51; 95%<jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>: 0.24\u20139.43; p = 0.66) for the groups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Through our meta\u2010analysis, allograft nephrectomy before re\u2010transplantation seemed well tolerated but conferred no significant benefit. The risk\u2013benefit ratio of transplant nephrectomy with re\u2010transplantation must be evaluated in each individual patient.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ctr.12654","type":"journal-article","created":{"date-parts":[[2015,10,13]],"date-time":"2015-10-13T14:52:21Z","timestamp":1444747941000},"page":"33-43","source":"Crossref","is-referenced-by-count":23,"title":["Allograft nephrectomy vs. no\u2010allograft nephrectomy for renal transplantation: a meta\u2010analysis"],"prefix":"10.1111","volume":"30","author":[{"given":"Kun","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Surgical Urology the Third Affiliated Hospital of Soochow University Changzhou Jiangsu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xianlin","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Surgical Urology the Third Affiliated Hospital of Soochow University Changzhou Jiangsu 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