{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T19:09:47Z","timestamp":1777748987154,"version":"3.51.4"},"reference-count":9,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2015,11,23]],"date-time":"2015-11-23T00:00:00Z","timestamp":1448236800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Astellas Canada"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Transplantation"],"published-print":{"date-parts":[[2016,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Little is known about the incidence, causes, and significance of acute kidney injury (<jats:styled-content style=\"fixed-case\">AKI<\/jats:styled-content>) in the early transplant period. This study used a definition as &gt;26 \u03bcmol\/L increase in creatinine within 48 h or &gt;50% increase over a period &gt;48 h. In 326 adult consecutive recipients of a solitary kidney transplant from 2006 to 2014 followed at this center, 21% developed <jats:styled-content style=\"fixed-case\">AKI<\/jats:styled-content> within the first six months. Most etiologies were <jats:styled-content style=\"fixed-case\">CNI<\/jats:styled-content> toxicity (33%) or unknown (26%), whereas acute rejection accounted for 17% and urinary tract obstruction for 10%. Those with <jats:styled-content style=\"fixed-case\">AKI<\/jats:styled-content> had a significantly lower glomerular filtration rate (<jats:styled-content style=\"fixed-case\">GFR<\/jats:styled-content>) at one\u2010yr post\u2010transplant (adjusted beta coefficient \u22125.5 mL\/min\/1.73 m<jats:sup>2<\/jats:sup>, 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>: \u221210.4, \u22120.7, p = 0.025) in a multivariable linear regression model. However, the <jats:styled-content style=\"fixed-case\">AKI<\/jats:styled-content> definition missed 6 of 19 episodes of acute rejection and 4 of 10 episodes of urinary tract obstruction. When acute rejection (including those that did not satisfy <jats:styled-content style=\"fixed-case\">AKI<\/jats:styled-content> criteria) was included in the model, other causes of <jats:styled-content style=\"fixed-case\">AKI<\/jats:styled-content> were not significantly associated with <jats:styled-content style=\"fixed-case\">GFR<\/jats:styled-content> at year 1. Although <jats:styled-content style=\"fixed-case\">AKI<\/jats:styled-content>, using current criteria, is likely to be a significant predictor of later outcomes, important causes are missed and the criteria are not sensitive for clinical decision\u2010making.<\/jats:p>","DOI":"10.1111\/ctr.12660","type":"journal-article","created":{"date-parts":[[2015,10,24]],"date-time":"2015-10-24T15:04:19Z","timestamp":1445699059000},"page":"66-70","source":"Crossref","is-referenced-by-count":14,"title":["Incidence, etiology, and significance of acute kidney injury in the early post\u2010kidney transplant period"],"prefix":"10.1111","volume":"30","author":[{"given":"Romuald","family":"Panek","sequence":"first","affiliation":[{"name":"Department of Medicine Dalhousie University Halifax NS Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karthik K.","family":"Tennankore","sequence":"additional","affiliation":[{"name":"Department of Medicine Dalhousie University Halifax NS Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bryce A.","family":"Kiberd","sequence":"additional","affiliation":[{"name":"Department of Medicine Dalhousie University Halifax NS Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2015,11,23]]},"reference":[{"key":"e_1_2_7_2_1","first-page":"1","article-title":"KDIGO Clinical practice guideline for acute kidney injury","volume":"2","year":"2012","journal-title":"Kidney Int Suppl"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2007080837"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.168.6.609"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.ajkd.2011.11.034"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-0012.2011.01546.x"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0272-6386(02)70054-1"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2014040378"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-6143.2009.02729.x"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.ajkd.2010.08.015"}],"container-title":["Clinical Transplantation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fctr.12660","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ctr.12660","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,3]],"date-time":"2023-10-03T02:30:29Z","timestamp":1696300229000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/ctr.12660"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,11,23]]},"references-count":9,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2016,1]]}},"alternative-id":["10.1111\/ctr.12660"],"URL":"https:\/\/doi.org\/10.1111\/ctr.12660","archive":["Portico"],"relation":{},"ISSN":["0902-0063","1399-0012"],"issn-type":[{"value":"0902-0063","type":"print"},{"value":"1399-0012","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,11,23]]}}}