{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T08:52:27Z","timestamp":1778835147349,"version":"3.51.4"},"reference-count":32,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2015,12,9]],"date-time":"2015-12-09T00:00:00Z","timestamp":1449619200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Transplantation"],"published-print":{"date-parts":[[2016,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Non\u2010anastomotic biliary strictures (<jats:styled-content style=\"fixed-case\">NAS<\/jats:styled-content>) after orthotopic liver transplantation (<jats:styled-content style=\"fixed-case\">OLT<\/jats:styled-content>) have a negative influence on graft survival. Expert opinion suggests a negative effect of <jats:styled-content style=\"fixed-case\">NAS<\/jats:styled-content> on other important aspects of post\u2010transplant care, although its impact is largely unknown as data are scarce.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This retrospective single center study analyzed data on healthcare consumption, use of ionizing radiation, infectious complications and development of highly resistant microorganisms (<jats:styled-content style=\"fixed-case\">HRMO<\/jats:styled-content>) in adult patients with <jats:styled-content style=\"fixed-case\">NAS<\/jats:styled-content>. A comparison with a matched control group was made.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Forty\u2010three liver recipients with <jats:styled-content style=\"fixed-case\">NAS<\/jats:styled-content> and 43 controls were included. Hospital admissions were higher in patients with <jats:styled-content style=\"fixed-case\">NAS<\/jats:styled-content>. Most common reason for admission was bacterial cholangitis (<jats:styled-content style=\"fixed-case\">BC<\/jats:styled-content>), with 70% of the patients having at least one episode compared to 9% in the control group. In patients with <jats:styled-content style=\"fixed-case\">NAS<\/jats:styled-content>, 67% received at least one <jats:styled-content style=\"fixed-case\">ERCP<\/jats:styled-content> compared to 21% in the control group (p = 0.001). This resulted in a larger yearly received radiation dose for patients with <jats:styled-content style=\"fixed-case\">NAS<\/jats:styled-content> (p = 0.001). Frequency of intravenous antibiotic therapy was higher (p = 0.001) for patients with <jats:styled-content style=\"fixed-case\">NAS<\/jats:styled-content>, consistently resulting in a higher number of cultures found with <jats:styled-content style=\"fixed-case\">HRMO<\/jats:styled-content> (p = 0.012).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p><jats:styled-content style=\"fixed-case\">NAS<\/jats:styled-content> after <jats:styled-content style=\"fixed-case\">OLT<\/jats:styled-content> have a negative effect on post\u2010transplant care, increasing readmission rates, interventional procedures, exposure to ionizing radiation, use of antibiotics, and development of <jats:styled-content style=\"fixed-case\">HRMO<\/jats:styled-content>.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ctr.12664","type":"journal-article","created":{"date-parts":[[2015,11,3]],"date-time":"2015-11-03T20:47:12Z","timestamp":1446583632000},"page":"81-89","source":"Crossref","is-referenced-by-count":6,"title":["Impact of non\u2010anastomotic biliary strictures after liver transplantation on healthcare consumption, use of ionizing radiation and infectious events"],"prefix":"10.1111","volume":"30","author":[{"given":"A. Boudewijn","family":"de Vries","sequence":"first","affiliation":[{"name":"Department of Gastroenterology and Hepatology Section of Hepatobiliary Surgery and Liver Transplantation University of Groningen University Medical Center Groningen Groningen the Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jan J.","family":"Koornstra","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology Section of Hepatobiliary Surgery and Liver Transplantation University of Groningen University Medical Center Groningen Groningen the Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jerome R.","family":"Lo Ten Foe","sequence":"additional","affiliation":[{"name":"Department of Microbiology Section of Hepatobiliary Surgery and Liver Transplantation University of Groningen University Medical Center Groningen Groningen the Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert J.","family":"Porte","sequence":"additional","affiliation":[{"name":"Department of Surgery Section of Hepatobiliary Surgery and Liver Transplantation University of Groningen University Medical Center Groningen Groningen the Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aad P.","family":"van den Berg","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology Section of Hepatobiliary Surgery and Liver Transplantation University of Groningen University Medical Center Groningen Groningen the Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hans","family":"Blokzijl","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology Section of Hepatobiliary Surgery and Liver Transplantation University of Groningen University Medical Center Groningen Groningen the Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert C.","family":"Verdonk","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology Section of Hepatobiliary Surgery and Liver Transplantation University of Groningen University Medical Center Groningen Groningen the Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2015,12,9]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1080\/00365520600664375"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/lt.21165"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1148\/radiology.177.1.2399328"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0676.2003.00823.x"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-2005-870192"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1432-2277.2001.tb00031.x"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/lt.21764"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/lt.21166"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1259\/bjr.71.842.9579182"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1067\/mge.2001.111389"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00330-006-0473-1"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ypmed.2011.12.017"},{"key":"e_1_2_6_14_1","unstructured":"Werkgroep Infectiepreventie (WIP). 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