{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,18]],"date-time":"2025-10-18T20:52:23Z","timestamp":1760820743201},"reference-count":40,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2015,12,16]],"date-time":"2015-12-16T00:00:00Z","timestamp":1450224000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Transplantation"],"published-print":{"date-parts":[[2016,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Literature reports suggest that non\u2010<jats:styled-content style=\"fixed-case\">HLA<\/jats:styled-content>\u2010antibodies against human endothelial progenitor cells (<jats:styled-content style=\"fixed-case\">EPC<\/jats:styled-content>) can be detected in pre\u2010transplant recipient serum and that <jats:styled-content style=\"fixed-case\">EPC<\/jats:styled-content> antibodies can have a deleterious influence on the graft.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We investigated 71 renal transplant recipients from living donors for a possible influence of pre\u2010transplant donor\u2010specific IgG and\/or IgM recipient antibodies against <jats:styled-content style=\"fixed-case\">EPC<\/jats:styled-content> of the donor using the flow cytometric <jats:styled-content style=\"fixed-case\">XM<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">ONE<\/jats:styled-content> cross\u2010match.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Eight of the 71 patients developed acute biopsy\u2010proven rejection. Two of these patients showed IgM antibodies against <jats:styled-content style=\"fixed-case\">EPC<\/jats:styled-content> prior to transplantation while the other six patients had neither IgG nor IgM <jats:styled-content style=\"fixed-case\">EPC<\/jats:styled-content> antibodies. Conversely, pre\u2010transplant IgG or IgM antibodies against <jats:styled-content style=\"fixed-case\">EPC<\/jats:styled-content> were detected in 19 patients without acute rejection (3 \u00d7 both IgG and IgM, 1 \u00d7 IgG and 15 \u00d7 IgM). The remaining 44 patients had neither <jats:styled-content style=\"fixed-case\">EPC<\/jats:styled-content> antibodies nor experienced rejection. Comparing serum creatinine levels at one month and one yr post\u2010transplant within and among the three patient groups revealed that serum creatinine levels were similar in patients with or without <jats:styled-content style=\"fixed-case\">EPC<\/jats:styled-content> antibodies (p &gt; 0.05).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>In this series of 71 recipients with living donor kidneys, pre\u2010transplant <jats:styled-content style=\"fixed-case\">EPC<\/jats:styled-content> antibodies detected with the <jats:styled-content style=\"fixed-case\">XM<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">ONE<\/jats:styled-content> test kit were neither associated with acute rejection nor with graft function at one month or one yr.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ctr.12665","type":"journal-article","created":{"date-parts":[[2015,11,5]],"date-time":"2015-11-05T06:20:45Z","timestamp":1446704445000},"page":"124-130","source":"Crossref","is-referenced-by-count":8,"title":["Clinical relevance of preformed IgG and IgM antibodies against donor endothelial progenitor cells in recipients of living donor kidney grafts"],"prefix":"10.1111","volume":"30","author":[{"given":"Volker","family":"Daniel","sequence":"first","affiliation":[{"name":"Department of Transplantation\u2010Immunology University Hospital Heidelberg Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mahmoud","family":"Sadeghi","sequence":"additional","affiliation":[{"name":"Department of Transplantation\u2010Immunology University Hospital Heidelberg Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Caner","family":"Suesal","sequence":"additional","affiliation":[{"name":"Department of 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