{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T21:00:18Z","timestamp":1790024418332,"version":"4.0.1"},"reference-count":54,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2016,2,11]],"date-time":"2016-02-11T00:00:00Z","timestamp":1455148800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Mayo Clinic Transplant Scholarly Physician Award"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Transplantation"],"published-print":{"date-parts":[[2016,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>\n                      Frailty in non\u2010transplant populations increases morbidity and mortality. Muscle wasting is an important frailty characteristic. Low body mass index is used to measure wasting, but can over\u2010 or underestimate muscle mass. Computed tomography (\n                      <jats:styled-content style=\"fixed-case\">CT<\/jats:styled-content>\n                      ) software can directly measure muscle mass. It is unknown if muscle wasting is important in lung transplantation.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Aim and Methods<\/jats:title>\n                    <jats:p>\n                      The aim of this single\u2010center, retrospective cohort study was to determine whether pre\u2010transplant low muscle mass (as measured by\n                      <jats:styled-content style=\"fixed-case\">CT<\/jats:styled-content>\n                      using Slice\u2010O\u2010matic software at L2\u2013L3 interspace) was associated with post\u2010transplantation mortality, hospital and intensive care unit length of stay (\n                      <jats:styled-content style=\"fixed-case\">LOS<\/jats:styled-content>\n                      ), duration of mechanical ventilation, or primary graft dysfunction. Lung transplant recipients from 2000 to 2012 with a\n                      <jats:styled-content style=\"fixed-case\">CT<\/jats:styled-content>\n                      scan less than six months prior to transplant were included. Univariate, multivariate, and Kaplan\u2013Meier analyses were conducted.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Thirty\u2010six patients were included. Those with low muscle index (lower 25th percentile) had a worse survival (hazard ratio = 3.83; 95% confidence interval 1.42\u201310.3; p = 0.007) and longer hospital\n                      <jats:styled-content style=\"fixed-case\">LOS<\/jats:styled-content>\n                      by an estimated 7.2 d (p = 0.01) when adjusted for age and sex as compared to those with higher muscle index.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>\n                      Low muscle index at lung transplantation is associated with worse survival and increased hospital\n                      <jats:styled-content style=\"fixed-case\">LOS<\/jats:styled-content>\n                      .\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/ctr.12683","type":"journal-article","created":{"date-parts":[[2015,12,24]],"date-time":"2015-12-24T04:38:46Z","timestamp":1450931926000},"page":"247-255","source":"Crossref","is-referenced-by-count":66,"title":["Pre\u2010transplant wasting (as measured by muscle index) is a novel prognostic indicator in lung transplantation"],"prefix":"10.1111","volume":"30","author":[{"given":"Diana J.","family":"Kelm","sequence":"first","affiliation":[{"name":"Division of Pulmonary Critical Care Medicine Department of Internal Medicine Mayo Clinic Rochester MN USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sara L.","family":"Bonnes","sequence":"additional","affiliation":[{"name":"Division of General Internal Medicine Department of Internal Medicine Mayo Clinic Rochester MN USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael D.","family":"Jensen","sequence":"additional","affiliation":[{"name":"Division of Endocrinology and Metabolic Diseases Department of Internal Medicine Mayo Clinic Rochester MN USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrick W.","family":"Eiken","sequence":"additional","affiliation":[{"name":"Department of Radiology Mayo Clinic Rochester MN USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew A.","family":"Hathcock","sequence":"additional","affiliation":[{"name":"Department of Health Sciences Research Mayo Clinic Rochester MN USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Walter K.","family":"Kremers","sequence":"additional","affiliation":[{"name":"Department of Health Sciences Research Mayo Clinic Rochester MN USA"},{"name":"William J. 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