{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,20]],"date-time":"2026-09-20T01:12:19Z","timestamp":1789866739263,"version":"4.0.1"},"reference-count":34,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2016,2,13]],"date-time":"2016-02-13T00:00:00Z","timestamp":1455321600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100005925","name":"Buddhist Tzu Chi Medical Foundation","doi-asserted-by":"publisher","award":["TCRD\u2010I9904\u201002"],"award-info":[{"award-number":["TCRD\u2010I9904\u201002"]}],"id":[{"id":"10.13039\/501100005925","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Transplantation"],"published-print":{"date-parts":[[2016,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>We aimed to investigate the roles of cytokines during polyomavirus <jats:styled-content style=\"fixed-case\">BK<\/jats:styled-content> (<jats:styled-content style=\"fixed-case\">BKV<\/jats:styled-content>) reactivation in renal transplant patients. Forty\u2010eight renal allograft recipients were enrolled, and their sera <jats:styled-content style=\"fixed-case\">BKV<\/jats:styled-content> viral load and <jats:styled-content style=\"fixed-case\">mRNA<\/jats:styled-content> expression levels of cytokines in peripheral blood mononuclear cells were measured by real\u2010time polymerase chain reaction. Patient's age and gene expression levels of interleukin (<jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>)\u20102 (10.04 \u00b1 2.63 vs. 8.70 \u00b1 2.40, p = 0.049) and transforming growth factor (<jats:styled-content style=\"fixed-case\">TGF<\/jats:styled-content>)\u2010\u03b2 (12.58 \u00b1 2.59 vs. 10.89 \u00b1 1.91, p = 0.015) were significantly higher in <jats:styled-content style=\"fixed-case\">BKV<\/jats:styled-content> viremia (+) renal transplant patients. Multivariate logistic regression analysis revealed that age and <jats:styled-content style=\"fixed-case\">mRNA<\/jats:styled-content> expression levels of <jats:styled-content style=\"fixed-case\">TGF<\/jats:styled-content>\u2010\u03b2, but not <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u20102, significantly correlated with the presence of <jats:styled-content style=\"fixed-case\">BKV<\/jats:styled-content> viremia. Sera <jats:styled-content style=\"fixed-case\">BKV<\/jats:styled-content> viral loads showed a positive correlation with patient age and the levels of <jats:styled-content style=\"fixed-case\">TGF<\/jats:styled-content>\u2010\u03b2 and <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u20106 <jats:styled-content style=\"fixed-case\">mRNA<\/jats:styled-content>. After adjusting for age and sex in the regression model, both age and <jats:styled-content style=\"fixed-case\">TGF<\/jats:styled-content>\u2010\u03b2 <jats:styled-content style=\"fixed-case\">mRNA<\/jats:styled-content> levels maintained a significant positive association with sera <jats:styled-content style=\"fixed-case\">BKV<\/jats:styled-content> viral loads. Serum <jats:styled-content style=\"fixed-case\">TGF<\/jats:styled-content>\u2010\u03b2 concentration tended to be higher in <jats:styled-content style=\"fixed-case\">BKV<\/jats:styled-content> viremia (+) patients (p = 0.079). In conclusion, expression levels of <jats:styled-content style=\"fixed-case\">TGF<\/jats:styled-content>\u2010\u03b2 were found to correlate with both <jats:styled-content style=\"fixed-case\">BKV<\/jats:styled-content> viremia positivity and sera <jats:styled-content style=\"fixed-case\">BKV<\/jats:styled-content> viral loads in renal transplant patients.<\/jats:p>","DOI":"10.1111\/ctr.12698","type":"journal-article","created":{"date-parts":[[2016,1,19]],"date-time":"2016-01-19T13:27:00Z","timestamp":1453210020000},"page":"393-398","source":"Crossref","is-referenced-by-count":3,"title":["Increased gene expression of <scp>TGF<\/scp>\u2010\u03b2 in peripheral blood mononuclear cells from renal transplant patients with polyomavirus <scp>BK<\/scp> viremia"],"prefix":"10.1111","volume":"30","author":[{"given":"Wen\u2010Yao","family":"Yin","sequence":"first","affiliation":[{"name":"Division of General Surgery Dalin Tzu Chi Hospital Buddhist Tzu Chi Medical Foundation Chiayi Taiwan"},{"name":"School of Medicine Tzu Chi University Hualien Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ming\u2010Che","family":"Lee","sequence":"additional","affiliation":[{"name":"School of Medicine Tzu Chi University Hualien Taiwan"},{"name":"Department of General Surgery Hualien Tzu Chi Medical Center Hualien Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hsien\u2010Bin","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Life Science and Institute of Molecular Biology National Chung Cheng University  Chiayi Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ming\u2010Chi","family":"Lu","sequence":"additional","affiliation":[{"name":"School of Medicine Tzu Chi University Hualien Taiwan"},{"name":"Division of Allergy Immunology and Rheumatology Dalin Tzu Chi Hospital Buddhist Tzu Chi Medical Foundation Chiayi 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