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Calcineurin inhibitors (<jats:styled-content style=\"fixed-case\">CNI<\/jats:styled-content>s) are the primary agents used for patients undergoing liver transplantation. Other therapeutic agents like interleukin\u20102 receptor antagonists are not universally administered, but can be considered for the delay or reduction in <jats:styled-content style=\"fixed-case\">CNI<\/jats:styled-content> exposure. An early addition of mycophenolate mofetil (<jats:styled-content style=\"fixed-case\">MMF<\/jats:styled-content>) or the <jats:styled-content style=\"fixed-case\">mTOR<\/jats:styled-content> inhibitor everolimus also allows for the reduction in the <jats:styled-content style=\"fixed-case\">CNI<\/jats:styled-content> dose. To reduce the risk of malignancy, in particular of skin tumors, as well as to prevent the deterioration of renal function, everolimus\u2010based therapy may be advantageous. Apart from patients with autoimmune hepatitis, steroids are withdrawn within 3\u20136 months after transplantation. Overall, immunosuppression can only be standardized in a limited proportion of patients due to specific clinical requirements and risk factors. 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