{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,13]],"date-time":"2026-02-13T17:03:11Z","timestamp":1771002191626,"version":"3.50.1"},"reference-count":30,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2016,3,1]],"date-time":"2016-03-01T00:00:00Z","timestamp":1456790400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Transplantation"],"published-print":{"date-parts":[[2016,4]]},"abstract":"Abstract<\/jats:title>Hepatitis C virus (HCV<\/jats:styled-content>) infection is accelerated following liver transplantation (LT<\/jats:styled-content>). Single nucleotide polymorphisms (SNP<\/jats:styled-content>s) near the epidermal growth factor (EGF<\/jats:styled-content><\/jats:italic>) (rs4444903), IL<\/jats:styled-content>28B<\/jats:italic> (rs12979860), and PNPLA<\/jats:styled-content>3<\/jats:italic> (rs738409) loci are associated with treatment response, fibrosis, and hepatocellular carcinoma in non\u2010transplant hepatitis C, but allograft population data are limited. We sought to determine the role of these SNP<\/jats:styled-content>s in 264 patients with HCV<\/jats:styled-content> who underwent LT<\/jats:styled-content> between 1990 and 2008. Genotypes were determined from donor wedge\/allograft biopsies and recipient explants. Cox proportional hazards model was used to assess time to cirrhosis, liver\u2010related death, and retransplantation, adjusting for donor age and sustained virological response (SVR<\/jats:styled-content>). Over a median follow\u2010up of 6.3 yr, a trend toward increased progression to graft cirrhosis was observed among recipients of an EGF<\/jats:styled-content><\/jats:italic> non\u2010AA<\/jats:styled-content> vs. AA<\/jats:styled-content> donor liver (adjusted HR<\/jats:styled-content> 2.01; 95% CI<\/jats:styled-content> 0.93\u20134.34; p = 0.08). No other genotypes predicted cirrhosis development or graft survival. The CC <\/jats:styled-content>IL<\/jats:styled-content>28B<\/jats:italic> variant in both recipients and donors was associated with increased rate of SVR<\/jats:styled-content> (R\u2010CC<\/jats:styled-content>\/D\u2010CC<\/jats:styled-content> 8\/12[67%], R\u2010non\u2010CC<\/jats:styled-content>\/D\u2010CC<\/jats:styled-content> or R\u2010CC<\/jats:styled-content>\/D\u2010non\u2010CC<\/jats:styled-content> 23\/52[44%], R\u2010non\u2010CC<\/jats:styled-content>\/D\u2010non\u2010CC<\/jats:styled-content> 12\/45[27%], p linear trend = 0.009). Recipient EGF<\/jats:styled-content><\/jats:italic>, IL<\/jats:styled-content>28B<\/jats:italic>, and PNPLA<\/jats:styled-content>3,<\/jats:italic> and donor IL<\/jats:styled-content>28B<\/jats:italic> and PNPLA<\/jats:styled-content>3<\/jats:italic> genotypes do not predict adverse outcomes in HCV LT<\/jats:styled-content> recipients. A potential association exists between donor EGF<\/jats:styled-content><\/jats:italic> genotype and cirrhosis.<\/jats:p>","DOI":"10.1111\/ctr.12710","type":"journal-article","created":{"date-parts":[[2016,2,8]],"date-time":"2016-02-08T17:39:14Z","timestamp":1454953154000},"page":"452-460","source":"Crossref","is-referenced-by-count":1,"title":["Impact of EGF<\/scp><\/i>,IL<\/scp>28B<\/i>, and PNPLA<\/scp>3<\/i> polymorphisms on the outcome of allograft hepatitis C: a multicenter study"],"prefix":"10.1111","volume":"30","author":[{"given":"Jessica L.","family":"Mueller","sequence":"first","affiliation":[{"name":"Division of Gastroenterology Department of Medicine Massachusetts General Hospital Boston MA USA"},{"name":"Harvard Medical School Boston MA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lindsay Y.","family":"King","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology Department of Medicine Massachusetts General Hospital Boston MA USA"},{"name":"Harvard Medical School Boston MA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kara B.","family":"Johnson","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology Department of Medicine Massachusetts General Hospital Boston MA USA"},{"name":"Harvard Medical School Boston MA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tian","family":"Gao","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology Department of Medicine Boston Medical Center Boston MA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lauren D.","family":"Nephew","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology Department of Medicine University of Pennsylvania Health System Philadelphia PA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Darshan","family":"Kothari","sequence":"additional","affiliation":[{"name":"Harvard Medical School Boston MA USA"},{"name":"Division of Gastroenterology Department of Medicine Beth Israel Deaconness Medical Center Boston MA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mary Ann","family":"Simpson","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology Department of Medicine Lahey Hospital & Medical Center Burlington MA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hui","family":"Zheng","sequence":"additional","affiliation":[{"name":"Biostatistics Center Massachusetts General Hospital Boston MA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lan","family":"Wei","sequence":"additional","affiliation":[{"name":"Division of Surgical Oncology Department of Surgery Massachusetts General Hospital Boston MA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kathleen E.","family":"Corey","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology Department of Medicine Massachusetts General Hospital Boston MA USA"},{"name":"Harvard Medical School Boston MA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joseph","family":"Misdraji","sequence":"additional","affiliation":[{"name":"Department of Pathology Massachusetts General Hospital Boston MA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joon Hyoek","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Medicine Samsung Medical Center Sungkyunkwan University School of Medicine Seoul South Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M. Valerie","family":"Lin","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology Department of Medicine Massachusetts General Hospital Boston MA USA"},{"name":"Harvard Medical School Boston MA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Neliswa A.","family":"Gogela","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology Department of Medicine Massachusetts General Hospital Boston MA USA"},{"name":"Harvard Medical School Boston MA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bryan C.","family":"Fuchs","sequence":"additional","affiliation":[{"name":"Harvard Medical School Boston MA USA"},{"name":"Division of Surgical Oncology Department of Surgery Massachusetts General Hospital Boston MA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kenneth K.","family":"Tanabe","sequence":"additional","affiliation":[{"name":"Harvard Medical School Boston MA USA"},{"name":"Division of Surgical Oncology Department of Surgery Massachusetts General Hospital Boston MA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fredric D.","family":"Gordon","sequence":"additional","affiliation":[{"name":"Harvard Medical School Boston MA USA"},{"name":"Division of Gastroenterology Department of Medicine Lahey Hospital & Medical Center Burlington MA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael P.","family":"Curry","sequence":"additional","affiliation":[{"name":"Harvard Medical School Boston MA USA"},{"name":"Division of Gastroenterology Department of Medicine Beth Israel Deaconness Medical Center Boston MA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Raymond T.","family":"Chung","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology Department of Medicine Massachusetts General Hospital Boston MA USA"},{"name":"Harvard Medical School Boston MA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2016,3]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0168-8278(00)80231-7"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199603283341302"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/00007890-200201150-00010"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1053\/gast.2002.32418"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2007.65"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2011.03.045"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cyto.2011.10.018"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0114747"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.24350"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.24123"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.26767"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature08309"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature08463"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.26506"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2010.07.019"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10875-011-9547-1"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1097\/TP.0b013e3182547551"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2010.10.037"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-6143.2011.03491.x"},{"key":"e_1_2_7_21_1","doi-asserted-by":"crossref","first-page":"644","DOI":"10.1097\/TP.0b013e318244f774","article-title":"Role 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