{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,20]],"date-time":"2026-02-20T17:18:40Z","timestamp":1771607920968,"version":"3.50.1"},"reference-count":39,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2016,3,27]],"date-time":"2016-03-27T00:00:00Z","timestamp":1459036800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Transplantation"],"published-print":{"date-parts":[[2016,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To characterize the risk of liver\u2010related events and death in hepatitis B virus (<jats:styled-content style=\"fixed-case\">HBV<\/jats:styled-content>)\u2010exposed liver transplantation (<jats:styled-content style=\"fixed-case\">LT<\/jats:styled-content>) recipients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Retrospective review was performed in all adults who underwent<jats:styled-content style=\"fixed-case\">LT<\/jats:styled-content>between January 1995 through December 2010 at the Johns Hopkins Hospital. Recipients with graft failure or death within 14 d of<jats:styled-content style=\"fixed-case\">LT<\/jats:styled-content>or missing<jats:styled-content style=\"fixed-case\">HBV<\/jats:styled-content>status were excluded, leaving 575 individuals for analysis. Patients were classified according to<jats:styled-content style=\"fixed-case\">HBV<\/jats:styled-content>exposure status: Unexposed, Resolved<jats:styled-content style=\"fixed-case\">HBV<\/jats:styled-content>, Chronic<jats:styled-content style=\"fixed-case\">HBV<\/jats:styled-content>, or hepatitis B core antibody (anti\u2010<jats:styled-content style=\"fixed-case\">HB<\/jats:styled-content>c) seropositive liver donor.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Compared with<jats:styled-content style=\"fixed-case\">HBV<\/jats:styled-content>\u2010unexposed patients, the relative hazard of combined liver\u2010related events (rejection, cirrhosis, re\u2010transplantation) and death after<jats:styled-content style=\"fixed-case\">LT<\/jats:styled-content>was not increased in patients with a baseline history of resolved<jats:styled-content style=\"fixed-case\">HBV<\/jats:styled-content>infection or chronic hepatitis B. Using anti\u2010<jats:styled-content style=\"fixed-case\">HB<\/jats:styled-content>c seropositive donors also did not increase the risk of liver\u2010related events, death, or composite events (all p \u2265 0.05). However, hepatitis C was associated with liver\u2010related events [adjusted hazard ratio (<jats:styled-content style=\"fixed-case\">aHR<\/jats:styled-content>), 1.59; 95% confidence interval (<jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>), 1.00\u20132.52], and blacks had a higher risk of death (<jats:styled-content style=\"fixed-case\">aHR<\/jats:styled-content>, 1.50; 95%<jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>, 1.01\u20132.22).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p><jats:styled-content style=\"fixed-case\">LT<\/jats:styled-content>of patients with prior<jats:styled-content style=\"fixed-case\">HBV<\/jats:styled-content>exposure or use of anti\u2010<jats:styled-content style=\"fixed-case\">HB<\/jats:styled-content>c seropositive donors is not associated with increased risk of liver\u2010related events or death.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ctr.12723","type":"journal-article","created":{"date-parts":[[2016,2,26]],"date-time":"2016-02-26T03:16:51Z","timestamp":1456456611000},"page":"579-588","source":"Crossref","is-referenced-by-count":5,"title":["Effect of prior hepatitis B virus exposure on long\u2010term risk of liver\u2010related events after liver transplantation"],"prefix":"10.1111","volume":"30","author":[{"given":"Po\u2010Hung","family":"Chen","sequence":"first","affiliation":[{"name":"Division of Gastroenterology &amp; Hepatology Johns Hopkins University School of Medicine Baltimore MD USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Berkeley N.","family":"Limketkai","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology &amp; Hepatology Stanford University School of Medicine Stanford CA 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Southern California Los Angeles CA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Murat T.","family":"Gulsen","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology &amp; Hepatology Johns Hopkins University School of Medicine Baltimore MD USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dorry L.","family":"Segev","sequence":"additional","affiliation":[{"name":"Department of Surgery Johns Hopkins University School of Medicine Baltimore MD USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrew M.","family":"Cameron","sequence":"additional","affiliation":[{"name":"Department of Surgery Johns Hopkins University School of Medicine Baltimore MD USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ahmet","family":"Gurakar","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology &amp; Hepatology Johns Hopkins University School of Medicine Baltimore MD 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