{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,14]],"date-time":"2026-02-14T12:43:27Z","timestamp":1771073007683,"version":"3.50.1"},"reference-count":23,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2016,4,8]],"date-time":"2016-04-08T00:00:00Z","timestamp":1460073600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Transplantation"],"published-print":{"date-parts":[[2016,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Pre\u2010operative statin use has shown to reduce the incidence of post\u2010operative atrial fibrillation (<jats:styled-content style=\"fixed-case\">AF<\/jats:styled-content>), but not mortality in patients undergoing cardiac surgery. This association, however, has not been examined in a heart transplant (HT) cohort.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Adults (\u226518 yr) who underwent HT between 1997 and 2007 at the University of Minnesota were retrospectively identified. Primary outcome was 30\u2010d mortality after HT. Secondary outcomes were 30\u2010d incidence of <jats:styled-content style=\"fixed-case\">AF<\/jats:styled-content> and time to all\u2010cause mortality.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Data from 259 patients (mean age 52.0 \u00b1 11.7 yr, 81% males) were analyzed. Total of 133 (51%) patients were on statin pre\u2010operatively at the time of HT and constituted the statin group. During a mean follow\u2010up of 6.7 \u00b1 3.7 yr, 82 (32%) deaths occurred, 21 (8%) of which occurred within 30 d of HT. The incidence of 30\u2010d mortality was not significantly different between the statin and no\u2010statin groups (9% vs. 7%, p = 0.58). Further, cumulative long\u2010term survival after HT was not significantly different between the study groups (log\u2010rank p = 0.49). Pre\u2010transplant statin use did not impact the 30\u2010d incidence of post\u2010transplant <jats:styled-content style=\"fixed-case\">AF<\/jats:styled-content> (16% vs. 19%, p = 0.59).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Pre\u2010operative statin therapy does not seem to influence the risk of mortality or early post\u2010operative <jats:styled-content style=\"fixed-case\">AF<\/jats:styled-content> after <jats:styled-content style=\"fixed-case\">HT<\/jats:styled-content>. Future large\u2010scale studies are required to validate these preliminary findings.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ctr.12729","type":"journal-article","created":{"date-parts":[[2016,3,1]],"date-time":"2016-03-01T12:47:34Z","timestamp":1456836454000},"page":"628-632","source":"Crossref","is-referenced-by-count":8,"title":["Impact of pre\u2010operative statin use on risk of mortality and early atrial fibrillation after heart transplantation"],"prefix":"10.1111","volume":"30","author":[{"given":"Balaji","family":"Krishnan","sequence":"first","affiliation":[{"name":"Division of Cardiology Department of Medicine University of Minnesota Minneapolis MN USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kairav P.","family":"Vakil","sequence":"additional","affiliation":[{"name":"Division of Cardiology Section Heart Failure and Transplant Minneapolis Veterans Affairs Medical Center Minneapolis MN USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ashwini","family":"Sankar","sequence":"additional","affiliation":[{"name":"Division of Cardiology Department of Medicine University of Minnesota Minneapolis MN USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniel","family":"Duprez","sequence":"additional","affiliation":[{"name":"Division of Cardiology Department of Medicine University of Minnesota Minneapolis MN USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David G.","family":"Benditt","sequence":"additional","affiliation":[{"name":"Division of Cardiology Department of Medicine University of Minnesota Minneapolis MN USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2016,4,8]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1010-7940(99)00034-2"},{"key":"e_1_2_6_3_1","first-page":"CD008493","article-title":"Preoperative statin 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