{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,31]],"date-time":"2025-10-31T07:37:50Z","timestamp":1761896270581},"reference-count":25,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2016,4,24]],"date-time":"2016-04-24T00:00:00Z","timestamp":1461456000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Transplantation"],"published-print":{"date-parts":[[2016,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The interferon\u2010free antiviral regimen, sofosbuvir (<jats:styled-content style=\"fixed-case\">SOF<\/jats:styled-content>) and simeprevir (<jats:styled-content style=\"fixed-case\">SIM<\/jats:styled-content>) without ribavirin has been reported to achieve high sustained virologic response (<jats:styled-content style=\"fixed-case\">SVR<\/jats:styled-content>) rates with few adverse effects when treating patients with hepatitis <jats:styled-content style=\"fixed-case\">C<\/jats:styled-content> genotype 1 (<jats:styled-content style=\"fixed-case\">HCV GT<\/jats:styled-content>1) infection. However, there is scarcity of safety and efficacy data in this regimen after liver transplantation (<jats:styled-content style=\"fixed-case\">LT<\/jats:styled-content>).<\/jats:p><\/jats:sec><jats:sec><jats:title>Aim and methods<\/jats:title><jats:p>We aim to report the safety, tolerability and efficacy of <jats:styled-content style=\"fixed-case\">SOF<\/jats:styled-content> + <jats:styled-content style=\"fixed-case\">SIM<\/jats:styled-content> to treat <jats:styled-content style=\"fixed-case\">LT<\/jats:styled-content> recipients with recurrent <jats:styled-content style=\"fixed-case\">HCV GT<\/jats:styled-content>1 in a multicenter cohort study.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Eighty\u2010one patients with <jats:styled-content style=\"fixed-case\">HCV GT<\/jats:styled-content>1 met criteria to be considered for treatment. Sixty\u2010seven patients received <jats:styled-content style=\"fixed-case\">SOF<\/jats:styled-content> + <jats:styled-content style=\"fixed-case\">SIM<\/jats:styled-content> following <jats:styled-content style=\"fixed-case\">LT<\/jats:styled-content> to date: 69% male, 39% with <jats:styled-content style=\"fixed-case\">HCV RNA<\/jats:styled-content> &gt;6 000 000 IU\/mL, 22% advanced hepatic fibrosis (stage 3\u20134), 6% cholestatic recurrence. Fifty\u2010eight percent previously failed or did not tolerate interferon\u2010based treatments. Mean time from LT to treatment was 6.1 \u00b1 5.2 yr. All patients had estimated <jats:styled-content style=\"fixed-case\">GFR<\/jats:styled-content> &gt;30 mL\/min. Tacrolimus was primary immunosuppression in 84% of patients and minimal immunosuppression dose adjustments were required during treatment. In intention\u2010to\u2010treat analysis, 90% achieved end\u2010of\u2010treatment virologic response and 88% achieved <jats:styled-content style=\"fixed-case\">SVR<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Sofosbuvir + <jats:styled-content style=\"fixed-case\">SIM<\/jats:styled-content> combination therapy without ribavirin is well tolerated and results in high virologic response rates in recurrent <jats:styled-content style=\"fixed-case\">HCV GT<\/jats:styled-content>1 infection after liver transplantation.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ctr.12738","type":"journal-article","created":{"date-parts":[[2016,3,28]],"date-time":"2016-03-28T14:36:38Z","timestamp":1459175798000},"page":"709-713","source":"Crossref","is-referenced-by-count":17,"title":["Sofosbuvir and simeprevir without ribavirin effectively treat hepatitis <scp>C<\/scp> virus genotype 1 infection after liver transplantation in a two\u2010center 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