{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,7]],"date-time":"2025-11-07T19:08:37Z","timestamp":1762542517006},"reference-count":24,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2016,5,9]],"date-time":"2016-05-09T00:00:00Z","timestamp":1462752000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000102","name":"Health Resources and Services Administration","doi-asserted-by":"publisher","award":["231\u201000\u20100115"],"award-info":[{"award-number":["231\u201000\u20100115"]}],"id":[{"id":"10.13039\/100000102","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Transplantation"],"published-print":{"date-parts":[[2016,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Hormonal replacement therapy to brain\u2010dead potential organ donors remains controversial. A retrospective study was carried out of hormonal therapy on procurement of organs in 63 593 donors in whom information on thyroid hormone therapy (triiodothyronine or levothyroxine [T<jats:sub>3<\/jats:sub>\/T<jats:sub>4<\/jats:sub>]) was available. In 40 124 donors, T<jats:sub>3<\/jats:sub>\/T<jats:sub>4<\/jats:sub> and <jats:italic>all<\/jats:italic> other hormonal therapy were recorded. The percentage of all organs procured, except livers, was greater when T<jats:sub>3<\/jats:sub>\/T<jats:sub>4<\/jats:sub> had been administered. An independent beneficial effect of antidiuretic hormone (<jats:styled-content style=\"fixed-case\">ADH<\/jats:styled-content>) was also clear. Corticosteroids were less consistently beneficial (most frequently when T<jats:sub>3<\/jats:sub>\/T<jats:sub>4<\/jats:sub> had <jats:italic>not<\/jats:italic> been administered), although never detrimental. Insulin was almost never beneficial and at times was associated with a <jats:italic>reduced<\/jats:italic> yield of organs, particularly of the pancreas and intestine, an observation that does not appear to have been reported previously. In addition, there was <jats:italic>reduced<\/jats:italic> survival at 12 months of recipients of pancreases from T<jats:sub>3<\/jats:sub>\/T<jats:sub>4<\/jats:sub>\u2010treated donors, but not of pancreas grafts. The possibly detrimental effect observed following insulin therapy is discussed.<\/jats:p>","DOI":"10.1111\/ctr.12742","type":"journal-article","created":{"date-parts":[[2016,4,2]],"date-time":"2016-04-02T20:29:58Z","timestamp":1459628998000},"page":"754-759","source":"Crossref","is-referenced-by-count":13,"title":["Hormone resuscitation therapy for brain\u2010dead donors \u2013 is insulin beneficial or detrimental?"],"prefix":"10.1111","volume":"30","author":[{"given":"Dimitri","family":"Novitzky","sequence":"first","affiliation":[{"name":"Formerly Professor of Cardiothoracic Surgery University of South Florida Tampa FL USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhibao","family":"Mi","sequence":"additional","affiliation":[{"name":"Cooperative Studies Program Coordinating Center VA Medical Center Perry Point MD USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luis A.","family":"Videla","sequence":"additional","affiliation":[{"name":"Molecular and Clinical Pharmacology Program Institute of Biomedical Sciences Faculty of Medicine University of Chile Santiago Chile"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joseph F.","family":"Collins","sequence":"additional","affiliation":[{"name":"Cooperative Studies Program Coordinating Center VA Medical Center Perry Point MD USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David K. 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