{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T14:52:58Z","timestamp":1787755978294,"version":"build-2784847793"},"reference-count":38,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2016,6,18]],"date-time":"2016-06-18T00:00:00Z","timestamp":1466208000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Transplantation"],"published-print":{"date-parts":[[2016,8]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Prolonged\u2010release tacrolimus was developed as a once\u2010daily formulation with ethylcellulose as the excipient, resulting in slower release and reduction in peak concentration (\n                    <jats:italic>C<\/jats:italic>\n                    <jats:sub>max<\/jats:sub>\n                    ) for a given dose compared with immediate\u2010release tacrolimus, which is administered twice daily. This manuscript reviews pharmacokinetic information on prolonged\u2010release tacrolimus in healthy subjects, in transplant recipients converted from immediate\u2010release tacrolimus, and in de novo kidney and liver transplant recipients. As with the immediate\u2010release formulation, prolonged\u2010release tacrolimus shows a strong correlation between trough concentration (\n                    <jats:italic>C<\/jats:italic>\n                    <jats:sub>min<\/jats:sub>\n                    ) and area under the 24\u2010hour time\u2013concentration curve (\n                    <jats:styled-content style=\"fixed-case\">AUC<\/jats:styled-content>\n                    <jats:sub>24<\/jats:sub>\n                    ), indicating that trough whole blood concentrations provide an accurate measure of drug exposure. We present the pharmacokinetic similarities and differences between the two formulations, so that prescribing physicians will have a better understanding of therapeutic drug monitoring in patients receiving prolonged\u2010release tacrolimus.\n                  <\/jats:p>","DOI":"10.1111\/ctr.12763","type":"journal-article","created":{"date-parts":[[2016,5,24]],"date-time":"2016-05-24T20:45:48Z","timestamp":1464122748000},"page":"901-911","source":"Crossref","is-referenced-by-count":28,"title":["Pharmacokinetics of prolonged\u2010release tacrolimus and implications for use in solid organ transplant recipients"],"prefix":"10.1111","volume":"30","author":[{"given":"Maria G.","family":"Tanzi","sequence":"first","affiliation":[{"name":"Astellas Pharma Global Development Northbrook IL USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nasrullah","family":"Undre","sequence":"additional","affiliation":[{"name":"Astellas Pharma Europe Ltd Surrey UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James","family":"Keirns","sequence":"additional","affiliation":[{"name":"Astellas Pharma Global Development Northbrook IL USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William E.","family":"Fitzsimmons","sequence":"additional","affiliation":[{"name":"Astellas Pharma Global Development Northbrook IL USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Malcolm","family":"Brown","sequence":"additional","affiliation":[{"name":"Astellas Pharma Global Development Surrey UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. Roy","family":"First","sequence":"additional","affiliation":[{"name":"Transplant Genomics Inc. 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