{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,29]],"date-time":"2025-09-29T11:55:03Z","timestamp":1759146903319},"reference-count":34,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2016,7,11]],"date-time":"2016-07-11T00:00:00Z","timestamp":1468195200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81230013","81370666"],"award-info":[{"award-number":["81230013","81370666"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Transplantation"],"published-print":{"date-parts":[[2016,9]]},"abstract":"Abstract<\/jats:title>Objectives<\/jats:title>Allogeneic hematopoietic stem cell transplantation (HSCT<\/jats:styled-content>) is the only curative therapy for chronic myeloid leukemia (CML<\/jats:styled-content>) patients in blast crisis (BC<\/jats:styled-content>), and haploidentical donors (HID<\/jats:styled-content>) are immediately available for most patients. We compared the outcomes of HID<\/jats:styled-content> transplantation with those of matched related donor (MRD<\/jats:styled-content>) transplantation in a cohort study.<\/jats:p><\/jats:sec>Patients and Methods<\/jats:title>A total of 90 consecutive patients who received allogeneic HSCT<\/jats:styled-content> because of CML<\/jats:styled-content>\u2010BC<\/jats:styled-content> were investigated retrospectively. A total of 67 patients underwent transplantation from HID<\/jats:styled-content> and 23 from MRD<\/jats:styled-content>. Survival outcomes were compared between the two cohorts.<\/jats:p><\/jats:sec>Results<\/jats:title>Of the 90 patients, 86 patients were engrafted. Three\u2010year overall survival (OS<\/jats:styled-content>) and relapse\u2010free survival (RFS<\/jats:styled-content>) were comparable between HID<\/jats:styled-content> and MRD<\/jats:styled-content> recipients (OS<\/jats:styled-content>: 60.0% vs 55.3%, respectively, P<\/jats:italic>=.580; RFS<\/jats:styled-content>: 51.1% vs 47.8%, respectively, P<\/jats:italic>=.512). Three\u2010year incidences of transplant\u2010related mortality (TRM<\/jats:styled-content>) and relapse did not differ between HID<\/jats:styled-content> and MRD<\/jats:styled-content> recipients (relapse: 21.0% vs 26.1%, respectively, P<\/jats:italic>=.626; TRM<\/jats:styled-content>: 27.9% vs 26.1%, respectively, P<\/jats:italic>=.937). In multivariate analyses, previous chemotherapy history and not achieving CHR<\/jats:styled-content> before HSCT<\/jats:styled-content> are independent adverse predictors of OS<\/jats:styled-content>.<\/jats:p><\/jats:sec>Conclusions<\/jats:title>For CML<\/jats:styled-content>\u2010blast crisis or chronic phase from blast crisis patients, HID<\/jats:styled-content> transplantation achieves comparable survival to MRD<\/jats:styled-content> transplantation. HID<\/jats:styled-content> donors can be regarded as regular donors for these special patients at selected centers.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ctr.12779","type":"journal-article","created":{"date-parts":[[2016,6,13]],"date-time":"2016-06-13T06:57:06Z","timestamp":1465801026000},"page":"994-1001","source":"Crossref","is-referenced-by-count":13,"title":["Transplantation from haploidentical donor is not inferior to that from identical sibling donor for patients with chronic myeloid leukemia in blast crisis or chronic phase from blast crisis"],"prefix":"10.1111","volume":"30","author":[{"given":"Yan\u2010Ru","family":"Ma","sequence":"first","affiliation":[{"name":"Beijing Key Laboratory of Hematopoietic Stem Cell Transplantation Peking University Institute of Hematology Peking University People's Hospital Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiao\u2010Jun","family":"Huang","sequence":"additional","affiliation":[{"name":"Beijing Key Laboratory of Hematopoietic Stem Cell Transplantation Peking University Institute of Hematology Peking University People's Hospital Beijing China"},{"name":"Peking\u2010Tsinghua Center for Life Sciences Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zheng\u2010Li","family":"Xu","sequence":"additional","affiliation":[{"name":"Beijing Key Laboratory of Hematopoietic Stem Cell Transplantation Peking University Institute of Hematology Peking University People's Hospital Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kai\u2010Yan","family":"Liu","sequence":"additional","affiliation":[{"name":"Beijing Key Laboratory of Hematopoietic Stem Cell Transplantation Peking University Institute of Hematology Peking University People's Hospital Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Huan","family":"Chen","sequence":"additional","affiliation":[{"name":"Beijing Key Laboratory of Hematopoietic Stem Cell Transplantation Peking University Institute of Hematology Peking University People's Hospital Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiao\u2010Hui","family":"Zhang","sequence":"additional","affiliation":[{"name":"Beijing Key Laboratory of Hematopoietic Stem Cell Transplantation Peking University Institute of Hematology Peking University People's Hospital Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wei","family":"Han","sequence":"additional","affiliation":[{"name":"Beijing Key Laboratory of Hematopoietic Stem Cell Transplantation Peking University Institute of Hematology Peking University People's Hospital Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yu\u2010Hong","family":"Chen","sequence":"additional","affiliation":[{"name":"Beijing Key Laboratory of Hematopoietic Stem Cell Transplantation Peking University Institute of Hematology Peking University People's Hospital Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Feng\u2010Rong","family":"Wang","sequence":"additional","affiliation":[{"name":"Beijing Key Laboratory of Hematopoietic Stem Cell Transplantation Peking University Institute of Hematology Peking University People's Hospital Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jing\u2010Zhi","family":"Wang","sequence":"additional","affiliation":[{"name":"Beijing Key Laboratory of Hematopoietic Stem Cell Transplantation Peking University Institute of Hematology Peking University People's Hospital Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yu","family":"Wang","sequence":"additional","affiliation":[{"name":"Beijing Key Laboratory of Hematopoietic Stem Cell Transplantation Peking University Institute of Hematology Peking University People's Hospital Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yao","family":"Chen","sequence":"additional","affiliation":[{"name":"Beijing Key Laboratory of Hematopoietic Stem Cell Transplantation Peking University Institute of Hematology Peking University People's Hospital Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chen\u2010Hua","family":"Yan","sequence":"additional","affiliation":[{"name":"Beijing Key Laboratory of Hematopoietic Stem Cell Transplantation Peking University Institute of Hematology Peking University People's Hospital Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lan\u2010Ping","family":"Xu","sequence":"additional","affiliation":[{"name":"Beijing Key Laboratory of Hematopoietic Stem Cell Transplantation Peking University Institute of Hematology Peking University People's Hospital Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2016,7,11]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1182\/blood.V32.3.445.445","article-title":"Characteristics of the terminal phase of chronic granulocytic leukemia","volume":"32","author":"Karanas A","year":"1968","journal-title":"Blood"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2012-03-380147"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.13068"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.25123"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa055104"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2003-12-4111"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V99.10.3530"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2006-09-046888"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/bmt.2014.146"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.28433"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V99.7.2304"},{"key":"e_1_2_8_13_1","first-page":"513","article-title":"Allogeneic hematopoietic stem cell transplantation for chronic myeloid leukemia in Europe 2006: transplant activity, long\u2010term data and current results. An analysis by the Chronic Leukemia Working Party of the European Group for Blood and Marrow Transplantation (EBMT)","volume":"91","author":"Gratwohl A","year":"2006","journal-title":"Haematologica"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2010.32.0598"},{"key":"e_1_2_8_15_1","volume-title":"NCCN Guidelines: Chronic Myelogenous Leukemia","year":"2015"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2005-05-2146"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bmt.1700792"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1080\/07853890801908903"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2010-09-308510"},{"key":"e_1_2_8_20_1","first-page":"825","article-title":"1994 Consensus Conference on Acute GVHD Grading","volume":"15","author":"Przepiorka D","year":"1995","journal-title":"Bone Marrow Transplant"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.leukres.2013.06.003"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbmt.2010.07.023"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V100.2.406"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbmt.2010.08.023"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbmt.2011.08.024"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2012.44.3523"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbmt.2014.05.029"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.seminhematol.2016.01.005"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1038\/bmt.2009.311"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.leukres.2010.11.004"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2003-02-0430"},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2002-08-2619"},{"key":"e_1_2_8_33_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2009-08-237115"},{"key":"e_1_2_8_34_1","doi-asserted-by":"publisher","DOI":"10.1038\/leu.2010.115"},{"key":"e_1_2_8_35_1","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-14-0586"}],"container-title":["Clinical Transplantation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fctr.12779","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ctr.12779","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,3]],"date-time":"2023-10-03T03:36:39Z","timestamp":1696304199000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/ctr.12779"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,7,11]]},"references-count":34,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2016,9]]}},"alternative-id":["10.1111\/ctr.12779"],"URL":"https:\/\/doi.org\/10.1111\/ctr.12779","archive":["Portico"],"relation":{},"ISSN":["0902-0063","1399-0012"],"issn-type":[{"value":"0902-0063","type":"print"},{"value":"1399-0012","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,7,11]]}}}