{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,13]],"date-time":"2025-11-13T12:29:49Z","timestamp":1763036989692},"reference-count":17,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2016,7,2]],"date-time":"2016-07-02T00:00:00Z","timestamp":1467417600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Transplantation"],"published-print":{"date-parts":[[2016,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Hepatic steatosis threatens post\u2010transplant graft survival; therefore, pre\u2010operative quantification of steatosis is crucial. Gold standard for evaluation is donor liver biopsy but it is invasive. An alternative non\u2010invasive method is a calculation of <jats:styled-content style=\"fixed-case\">CT<\/jats:styled-content> liver attenuation index. <jats:styled-content style=\"fixed-case\">BMI<\/jats:styled-content> can be an independent factor predicting grade of steatosis but it is necessary to re\u2010define appropriate <jats:styled-content style=\"fixed-case\">BMI<\/jats:styled-content> cut\u2010off points that are specific for Asians.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>To retrospectively analyze <jats:styled-content style=\"fixed-case\">CT LAI<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">BMI<\/jats:styled-content> for quantitative assessment of macrovesicular steatosis in living related liver donors, using histological analysis as gold standard.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>A radiologist blinded to histological grading calculated mean <jats:styled-content style=\"fixed-case\">CT<\/jats:styled-content> hepatic attenuation in 48 potential living related liver donors.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p><jats:styled-content style=\"fixed-case\">CT<\/jats:styled-content>\u2010derived <jats:styled-content style=\"fixed-case\">LAI<\/jats:styled-content> correctly predicted steatosis in all except 1 patient. Parametric analysis for <jats:styled-content style=\"fixed-case\">CT LAI<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">BMI<\/jats:styled-content> showed overall weak positive correlation. No significant association was found between <jats:styled-content style=\"fixed-case\">BMI<\/jats:styled-content> and biopsy findings.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Liver biopsy remains a gold standard for evaluation of steatosis. <jats:styled-content style=\"fixed-case\">CT LAI<\/jats:styled-content> of \u22640 correlates well with significant hepatic steatosis and biopsy may be avoided in such cases. Biopsy may be reserved for patients with <jats:styled-content style=\"fixed-case\">CT LAI<\/jats:styled-content> between 1 and 5. <jats:styled-content style=\"fixed-case\">BMI<\/jats:styled-content> alone is not a good predictor of hepatic steatosis in our study population.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ctr.12782","type":"journal-article","created":{"date-parts":[[2016,6,13]],"date-time":"2016-06-13T07:07:39Z","timestamp":1465801659000},"page":"1016-1020","source":"Crossref","is-referenced-by-count":11,"title":["Macrovesicular steatosis in living related liver donors: correlation of biopsy findings with <scp>CT<\/scp> liver attenuation index and body mass index"],"prefix":"10.1111","volume":"30","author":[{"given":"Maham","family":"Jehangir","sequence":"first","affiliation":[{"name":"Department of Radiology Shifa International Hospital  Islamabad Pakistan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rashed","family":"Nazir","sequence":"additional","affiliation":[{"name":"Department of Radiology Shifa International Hospital  Islamabad Pakistan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aisha","family":"Jang","sequence":"additional","affiliation":[{"name":"Department of Radiology Shifa International Hospital  Islamabad Pakistan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Atif","family":"Rana","sequence":"additional","affiliation":[{"name":"Department of Radiology Shifa International Hospital  Islamabad Pakistan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Salman","family":"Rafique","sequence":"additional","affiliation":[{"name":"Department of Radiology Shifa International Hospital  Islamabad Pakistan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Faisal Saud","family":"Dar","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Liver Transplant Shifa International Hospital  Islamabad Pakistan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2016,7,2]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.2442061177"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.2391050361"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-111-6-473"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.2301021176"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00330-009-1560-x"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1477-2574.2012.00491.x"},{"key":"e_1_2_8_8_1","doi-asserted-by":"crossref","first-page":"66","DOI":"10.47102\/annals-acadmedsg.V38N1p66","article-title":"Rationale for redefining obesity in Asians","volume":"38","author":"Low S","year":"2009","journal-title":"Ann Acad Med Singapore"},{"key":"e_1_2_8_9_1","volume-title":"The Asia\u2010Pacific Perspective: Redefining Obesity and Its Treatment","author":"World Health Organization: Western Pacific Region","year":"2000"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1177\/088453360001500112"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.4329\/wjr.v6.i9.693"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4614-8498-1_4"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.2214\/AJR.06.0992"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00330-011-2349-2"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.10101233"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.TP.0000140499.23683.0D"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1053\/jlts.2001.23787"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.transproceed.2009.06.235"}],"container-title":["Clinical Transplantation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fctr.12782","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ctr.12782","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,3]],"date-time":"2023-10-03T03:37:12Z","timestamp":1696304232000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/ctr.12782"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,7,2]]},"references-count":17,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2016,9]]}},"alternative-id":["10.1111\/ctr.12782"],"URL":"https:\/\/doi.org\/10.1111\/ctr.12782","archive":["Portico"],"relation":{},"ISSN":["0902-0063","1399-0012"],"issn-type":[{"value":"0902-0063","type":"print"},{"value":"1399-0012","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,7,2]]}}}