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Bone mineral density (<jats:styled-content style=\"fixed-case\">BMD<\/jats:styled-content>) decreases following transplantation, leading to increased fracture risk. The effect of bisphosphonates on fracture is unknown. The aim of this study was to update estimates of change in <jats:styled-content style=\"fixed-case\">BMD<\/jats:styled-content> and fracture rates in bisphosphonate\u2010treated kidney transplant recipients through meta\u2010analysis. Studies comparing bisphosphonate therapy to standard of care were included if follow\u2010up duration was more than 6\u00a0months. We performed random\u2010effects meta\u2010analysis to determine the effect of bisphosphonates on lumbar spine and femoral neck <jats:styled-content style=\"fixed-case\">BMD<\/jats:styled-content> and fracture rates. Bisphosphonates improved femoral neck and lumbar spine <jats:styled-content style=\"fixed-case\">BMD<\/jats:styled-content> compared with controls (0.055\u00a0g\/cm<jats:sup>2<\/jats:sup>, 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> 0.012\u20130.099 and 0.053\u00a0g\/cm<jats:sup>2<\/jats:sup>, 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> 0.032\u20130.074, respectively) without adversely affecting serum creatinine or calcium. This corresponded to an unweighted improvement in <jats:styled-content style=\"fixed-case\">BMD<\/jats:styled-content> of 6.0% and 7.4%, respectively. There was no difference in fracture incidence in the two groups. Bisphosphonate therapy in kidney transplant recipients is associated with a statistically significant improvement in <jats:styled-content style=\"fixed-case\">BMD<\/jats:styled-content> at the lumbar spine and femoral neck. There was no difference in fracture incidence. Bisphosphonates did not adversely affect allograft dysfunction or serum calcium levels.<\/jats:p>","DOI":"10.1111\/ctr.12792","type":"journal-article","created":{"date-parts":[[2016,6,22]],"date-time":"2016-06-22T19:03:46Z","timestamp":1466622226000},"page":"1090-1096","source":"Crossref","is-referenced-by-count":35,"title":["Outcomes of bisphosphonate therapy in kidney transplant recipients: a systematic review and meta\u2010analysis"],"prefix":"10.1111","volume":"30","author":[{"given":"Stephanie M.","family":"Toth\u2010Manikowski","sequence":"first","affiliation":[{"name":"Department of Medicine Boston University School of Medicine  Boston MA USA"},{"name":"Division of Nephrology Department of Medicine Johns Hopkins University School of Medicine  Baltimore MD USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean M.","family":"Francis","sequence":"additional","affiliation":[{"name":"Renal Section and Department of Medicine Boston University School of Medicine  Boston MA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amitabh","family":"Gautam","sequence":"additional","affiliation":[{"name":"Section of Transplant Surgery Department of Surgery Boston University School of Medicine  Boston MA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Craig E.","family":"Gordon","sequence":"additional","affiliation":[{"name":"Renal Section and Department of Medicine Boston University School of Medicine  Boston MA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2016,7,19]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.2215\/CJN.02550508"},{"key":"e_1_2_9_3_1","first-page":"244","volume-title":"Bone Disease of Organ Transplantation","author":"Compston 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