{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T20:13:16Z","timestamp":1761595996528},"reference-count":20,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2016,8,3]],"date-time":"2016-08-03T00:00:00Z","timestamp":1470182400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100005564","name":"Gilead Sciences","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100005564","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003769","name":"Eisai","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003769","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006483","name":"AbbVie","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100006483","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Transplantation"],"published-print":{"date-parts":[[2016,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Human immunodeficiency virus (<jats:styled-content style=\"fixed-case\">HIV<\/jats:styled-content>)\u2010infected liver transplant (<jats:styled-content style=\"fixed-case\">LT<\/jats:styled-content>) recipients have higher risk of graft loss than <jats:styled-content style=\"fixed-case\">HIV<\/jats:styled-content>\u2010uninfected recipients. As the original donor risk index excluded <jats:styled-content style=\"fixed-case\">HIV<\/jats:styled-content>\u2010positive patients, donor factors associated with graft loss in <jats:styled-content style=\"fixed-case\">HIV<\/jats:styled-content>\u2010positive recipients are unknown.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Identifying all <jats:styled-content style=\"fixed-case\">HIV<\/jats:styled-content>\u2010positive patients in the Scientific Registry of Transplant Recipients, supplemented by all <jats:styled-content style=\"fixed-case\">HIV<\/jats:styled-content>\u2010infected patients in the solid organ transplantation in <jats:styled-content style=\"fixed-case\">HIV<\/jats:styled-content>: Multi\u2010Site Study (<jats:styled-content style=\"fixed-case\">HIV<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">TR<\/jats:styled-content>), we evaluated donor factors associated with graft loss among <jats:styled-content style=\"fixed-case\">HIV<\/jats:styled-content>\u2010positive recipients transplanted between March 2002 and August 2012.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 249 <jats:styled-content style=\"fixed-case\">HIV<\/jats:styled-content>\u2010positive <jats:styled-content style=\"fixed-case\">LT<\/jats:styled-content> recipients were followed for median 2.4 (interquartile range [<jats:styled-content style=\"fixed-case\">IQR<\/jats:styled-content>]: 0.8\u20134.9) years. In univariate analysis, donor diabetes (<jats:styled-content style=\"fixed-case\">HR<\/jats:styled-content>=2.09; <jats:italic>P<\/jats:italic>=.002) and donor hypertension (<jats:styled-content style=\"fixed-case\">HR<\/jats:styled-content>=1.43; <jats:italic>P<\/jats:italic>=.048) were significantly associated with graft loss, and African\u2010American (<jats:styled-content style=\"fixed-case\">AA<\/jats:styled-content>) recipient:non\u2010<jats:styled-content style=\"fixed-case\">AA<\/jats:styled-content> donor race mismatch (<jats:styled-content style=\"fixed-case\">HR<\/jats:styled-content>=1.60; <jats:italic>P<\/jats:italic>=.07), other cause of donor death compared to trauma (<jats:styled-content style=\"fixed-case\">HR<\/jats:styled-content>=2.02; <jats:italic>P<\/jats:italic>=.09), and donor age 30\u00a0years or older (<jats:styled-content style=\"fixed-case\">HR<\/jats:styled-content>=1.53; <jats:italic>P<\/jats:italic>=.05) were of borderline significance. In multivariate analysis, donor diabetes (<jats:styled-content style=\"fixed-case\">HR<\/jats:styled-content>=2.12; 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>: 1.33\u20133.38; <jats:italic>P<\/jats:italic>=.002) was the only significant predictor of graft loss.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>In <jats:styled-content style=\"fixed-case\">HIV<\/jats:styled-content>\u2010positive <jats:styled-content style=\"fixed-case\">LT<\/jats:styled-content> recipients, risk of graft loss is strongly influenced by donor diabetes. This information may be useful to transplant physicians seeking to optimize overall graft survival in their <jats:styled-content style=\"fixed-case\">HIV<\/jats:styled-content>\u2010positive <jats:styled-content style=\"fixed-case\">LT<\/jats:styled-content> recipients.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ctr.12800","type":"journal-article","created":{"date-parts":[[2016,7,14]],"date-time":"2016-07-14T01:01:37Z","timestamp":1468458097000},"page":"1140-1145","source":"Crossref","is-referenced-by-count":6,"title":["Key donor factors associated with graft loss among liver transplant recipients with human immunodeficiency virus"],"prefix":"10.1111","volume":"30","author":[{"given":"Isabel","family":"Campos\u2010Varela","sequence":"first","affiliation":[{"name":"Universidade de Santiago de Compostela (CLINURSID)  Santiago de Compostela Spain"},{"name":"Department of Internal Medicine Hospital of Santiago de Compostela  Santiago de Compostela Spain"},{"name":"Department of Medicine University of California\u2013San Francisco  San Francisco CA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jennifer L.","family":"Dodge","sequence":"additional","affiliation":[{"name":"Department of Surgery University of California\u2013San Francisco  San Francisco CA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter G.","family":"Stock","sequence":"additional","affiliation":[{"name":"Department of Surgery University of California\u2013San Francisco  San Francisco CA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Norah A.","family":"Terrault","sequence":"additional","affiliation":[{"name":"Department of Medicine University of California\u2013San Francisco  San Francisco CA USA"},{"name":"Department of Surgery University of California\u2013San Francisco  San Francisco CA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2016,8,3]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.166.15.1632"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-6143.2007.02061.x"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/TP.0000000000000829"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/lt.23411"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-6143.2012.04028.x"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/civ471"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.21990"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/ajt.12668"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2014.07.034"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-6143.2006.01242.x"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/lt.21699"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.26478"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2003.10.065"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjmed.2007.03.025"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0000000000000419"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0098104"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10620-012-2345-7"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/lt.23396"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciu731"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10620-011-1867-8"}],"container-title":["Clinical Transplantation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fctr.12800","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ctr.12800","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,3]],"date-time":"2023-10-03T03:37:28Z","timestamp":1696304248000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/ctr.12800"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,8,3]]},"references-count":20,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2016,9]]}},"alternative-id":["10.1111\/ctr.12800"],"URL":"https:\/\/doi.org\/10.1111\/ctr.12800","archive":["Portico"],"relation":{},"ISSN":["0902-0063","1399-0012"],"issn-type":[{"value":"0902-0063","type":"print"},{"value":"1399-0012","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,8,3]]}}}