{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,13]],"date-time":"2025-11-13T12:30:02Z","timestamp":1763037002924,"version":"3.37.3"},"reference-count":27,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2016,8,8]],"date-time":"2016-08-08T00:00:00Z","timestamp":1470614400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Transplantation"],"published-print":{"date-parts":[[2016,10]]},"abstract":"Abstract<\/jats:title>Background<\/jats:title>The aim of this study was to determine the long\u2010term efficacy of nucleos(t)ide analog (NA) and low\u2010dose hepatitis B immunoglobulin (HBIG<\/jats:styled-content>) combination treatment for preventing post\u2010transplant hepatitis B virus (HBV<\/jats:styled-content>) recurrence.<\/jats:p><\/jats:sec>Methods<\/jats:title>A total of 296 patients with HBV<\/jats:styled-content>\u2010associated liver disease who underwent liver transplantation (LT<\/jats:styled-content>) were enrolled. A combination of a daily NA and low\u2010dose HBIG<\/jats:styled-content> was used after LT<\/jats:styled-content>.<\/jats:p><\/jats:sec>Results<\/jats:title>The median follow\u2010up period was 46\u00a0months. HBV<\/jats:styled-content> recurrence occurred in eight patients. The cumulative probability of HBV<\/jats:styled-content> recurrence at 1, 3, 5, and 7\u00a0years was 1%, 3%, 3%, and 4%, respectively. Seven were on lamivudine (LMV<\/jats:styled-content>) or adefovir dipivoxil (ADV<\/jats:styled-content>), or LMV<\/jats:styled-content> and ADV<\/jats:styled-content> and HBIG<\/jats:styled-content> combination treatment and one entecavir (ETV<\/jats:styled-content>) and HBIG<\/jats:styled-content>. With Cox regression analysis, HBV<\/jats:styled-content> recurrence was determined to be associated with the presence of hepatocellular cancer (HCC<\/jats:styled-content>) prior to LT<\/jats:styled-content> (HR<\/jats:styled-content>: 12.3, P<\/jats:italic>=.02). Overall, 44 patients died. Survival was significantly better in the ETV<\/jats:styled-content> or tenofovir disoproxil fumarate (TDF<\/jats:styled-content>) and HBIG<\/jats:styled-content> group than the other group (P<\/jats:italic><.001).<\/jats:p><\/jats:sec>Conclusion<\/jats:title>The combination of ETV<\/jats:styled-content> or TDF<\/jats:styled-content> and low\u2010dose HBIG<\/jats:styled-content> achieved a more favorable prophylaxis against HBV<\/jats:styled-content> recurrence after LT<\/jats:styled-content>. The presence of HCC<\/jats:styled-content> prior to LT<\/jats:styled-content> was associated with post\u2010transplant HBV<\/jats:styled-content> recurrence.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ctr.12804","type":"journal-article","created":{"date-parts":[[2016,7,14]],"date-time":"2016-07-14T01:28:10Z","timestamp":1468459690000},"page":"1216-1221","source":"Crossref","is-referenced-by-count":15,"title":["The long\u2010term efficacy of combining nucleos(t)ide analog and low\u2010dose hepatitis B immunoglobulin on post\u2010transplant hepatitis B virus recurrence"],"prefix":"10.1111","volume":"30","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8840-5472","authenticated-orcid":false,"given":"Ramazan","family":"Idilman","sequence":"first","affiliation":[{"name":"Department of Gastroenterology Ankara University School of Medicine Ankara Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Murat","family":"Akyildiz","sequence":"additional","affiliation":[{"name":"Istanbul Bilim University Faculty of Medicine Sisli Florence Nightingale Hospital Organ Transplantation Center Istanbul Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Onur","family":"Keskin","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Ankara University School of Medicine Ankara Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gokhan","family":"Gungor","sequence":"additional","affiliation":[{"name":"Istanbul Bilim University Faculty of Medicine Sisli Florence Nightingale Hospital Organ Transplantation Center Istanbul Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tonguc U.","family":"Yilmaz","sequence":"additional","affiliation":[{"name":"Istanbul Bilim University Faculty of Medicine Sisli Florence Nightingale Hospital Organ Transplantation Center Istanbul Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cagdas","family":"Kalkan","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Ankara University School of Medicine Ankara Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Murat","family":"Dayangac","sequence":"additional","affiliation":[{"name":"Istanbul Bilim University Faculty of Medicine Sisli Florence Nightingale Hospital Organ Transplantation Center Istanbul Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kubilay","family":"Cinar","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Ankara University School of Medicine Ankara Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Deniz","family":"Balci","sequence":"additional","affiliation":[{"name":"Department of Surgery Ankara University School of Medicine Ankara Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Selcuk","family":"Hazinedaroglu","sequence":"additional","affiliation":[{"name":"Department of Surgery Ankara University School of Medicine Ankara Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yaman","family":"Tokat","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Ankara University School of Medicine Ankara Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2016,8,8]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmi.2015.06.028"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1023\/A:1010705910858"},{"key":"e_1_2_6_4_1","unstructured":"Website of Minister of Health of the Republic of Turkey. 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